The stop-hole technique is a well-known strategy to extend the fatigue life of cracked components. The ability to estimate fatigue life after the hole is important for safety reasons. The objective here is to develop strategies for the accurate prediction of initiation and propagation life ahead of the stop-hole. Experimental work was developed in a Compact-Tension (CT) specimen made of 7050-T7451 aluminium alloy and with a 3 mm diameter hole. A total number of 625,000 load cycles were required to re-initiate the crack after the hole. Crack initiation life after the hole was estimated using the Theory of Critical Distances combined with the Smith–Watson–Topper parameter. A value of a0 = 31.83 µm was obtained for El Haddad parameter, which was used to define the critical distance. The predicted life was found to be only 4% lower than the experimental value. The fatigue crack growth (FCG) rate was calculated using a node release strategy, assuming that cyclic plastic deformation is the main damage mechanism and that cumulative plastic strain is the crack driving parameter. A good agreement was found between the numerical predictions of da/dN and the experimental results. The main result, however, is the proposed methodology, which allows predicting the initiation and propagation lives in notched components.