Effect of L-thyroxine on secretory response to histamine in ex vivo canine stomach perfused with homologous blood of thyroidectomized dog

Kowalewski, K.; Kolodej, A.

doi:10.1007/bf01073338

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Thus, we were able to compare the control state of normothyroidism with induced thyroid deficiency. Total thyroidectomy was performed, but the parathyroids were left intact (4,7). On the 3rd day following surgery, treatment with thiouracil began.…”

Section: Induction O F Hypothyroidismmentioning

confidence: 99%

Gastric Mucinous Secretion under Various Conditions of Stimulation in Hypothyroid Dogs

Kowalewski¹,

Pachkowski²,

Secord³

1977

Pharmacology

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Principal glycoproteins and amino acids of the secretions from Heidenhain pouches, were studied in normothyroid and hypothyroid Labrador dogs in the resting state, following injection of pentagastrin, histamine and after feeding. Hypothyroidism was produced by total thyroidectomy and chronic treatment with thiouracil. All samples showed the presence of galactose, glucosamine, galactosamine, fucose, mannose, uronic acid and sulfate. Galactose and glucosamine were found in equimolar amounts and the galactose to galactosamine ratio was 2:1. Concentrations of most carbohydrate components studied were higher in normothyroid than in hypothyroid dogs. Concentrations of most amino acids analyzed were also higher in normothyroid than in hypothyroid dogs, following stimulation with secretagogues.

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Section: Induction O F Hypothyroidismmentioning

confidence: 99%

Gastric Mucinous Secretion under Various Conditions of Stimulation in Hypothyroid Dogs

Kowalewski¹,

Pachkowski²,

Secord³

1977

Pharmacology

Self Cite

View full text Add to dashboard Cite

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Myoelectrical and mechanical activity of stomach and intestine in hypothyroid dogs

Kowalewski

Kolodej

1977

Digest Dis Sci

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Myoelectrical activity was studied in normothyroid and hypothyroid Labrador dogs in the resting state, following injection of pentagastrin, bethanechol chloride, and after feeding. Hypothyroidism was produced by total thyroidectomy and chronic treatment with thiouracil. Electrodes were surgically implanted over the serosa of the stomach, duodenum, jejunum, and ileum and used for repeated recording of myoelectrical activity of gastrointestinal muscles. A strain gauge was implanted over the gastric antrum and served to record mechanical activity of the stomach. As compared with control dogs, hypothyroid animals showed (a) decreased frequency of electrical control activity of the stomach and jejunum, (b) decreased occurrence of electrical response activity (spike potentials) following stimulation, and (c) decreased mechanical response to the same stimulants, ie, pentagastrin, bethanechol chloride, and food.

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Effect of L-thyroxine on secretory response to histamine in ex vivo canine stomach perfused with homologous blood of thyroidectomized dog

Cited by 2 publications

References 16 publications

Gastric Mucinous Secretion under Various Conditions of Stimulation in Hypothyroid Dogs

Gastric Mucinous Secretion under Various Conditions of Stimulation in Hypothyroid Dogs

Myoelectrical and mechanical activity of stomach and intestine in hypothyroid dogs

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