Effect of L- to D-Peptide Isomerisation on the Activity of Antimicrobial Peptide Anoplin

Abstract

water-soluble polymer, PEG, to the lamellar phase of DMPC or of several surfactants, induces a topological transformation to a vesicular phase. Such transition can be understood in terms of a modification of the elastic properties of the membranes. In this work we perform a dynamic light scattering (DLS) study of the effect of PEG on phospholipid and surfactant bilayers. The experimental results show that the addition of the polymer slows down the dynamics of the membranes. From fits to an available theory for the scattering of dilute membrane systems, we have calculated the bending elastic modulus of the bilayers. This modulus increases with increasing polymer concentration, thus confirming that the macromolecule modifies the elastic properties of the membranes.