Effect of L1210 leukemia on the susceptibility of mice to Candida albicans infections

Abstract

This study was carried out to determine whether animals bearing L1210 leukemia were more susceptible to candida infection in the absence of immunosuppression and to determine also if the L1210 cells suppressed the inflammatory response of the animal host. Systemic infection was studied by intravenous injection of Candida albicans and checking for the number of candida organisms cultured from the blood and the kidneys. Localized infection was studied by

Augmentation of Host Resistance to Candida albicans Infection in Ascites Tumor‐Bearing Mice

“…However, it has been indicated that normal defense mechanisms, i.e., complement and other serum factors, macrophages and PMNs, are primarily responsible for host defense against C. albicans infection (7). Johnson et al (5) reported that mice bearing ascites L1210 leukemia exhibited increased susceptibility to systemic Candida infection and also showed a reduction in the accumulation of PMNs. Little was known, however, about augmentation of (6) and in ascites form, exhibited resistance against C. albicans infection.…”

Delayed lethal response toAspergillus fumigatusinfection in sarcoma 180 tumor-bearing mice

“…Though the importance of medical treatments is now pointed out for this type of infection, it is thought that the experiments using simple models such as tumor‐bearing mice are needed to solve these problems. There are many papers concerning the increased susceptibility of tumor‐bearing hosts to systemic fungal infections [1–4]. However, the protective activity of tumor‐bearing mice against the most important pathogenic yeast, Candida albicans , infection has been reported in our previous papers [5–7] and by others [8].…”