Effect of lactic acid producing bacteria on the human intestinal microflora during ampicillin treatment

Abstract

20 healthy volunteers participated in a double blind study concerning the effect of lactic acid producing bacteria on the intestinal microflora during ampicillin treatment. 10 volunteers received 500 mg ampicillin tablets t.i.d. together with capsules containing lactic acid producing bacteria (Lactobacillus acidophilus and Bifidobacterium bifidum) for 7 days, and the other 10 volunteers were given 500 mg ampicillin tablets together with placebo capsules t.i.d. for 7 days. Both groups of volunteers continued the intake of the capsules t.i.d. for another 14 days after the ampicillin administration had been completed. The number of enterococci, streptococci and corynebacteria decreased during ampicillin administration but returned to normal levels after 14 days. Yeasts increased during the antibiotic treatment but returned to the same levels as before treatment within 14 days. Escherichia coli strains were suppressed in most volunteers during ampicillin administration. The numbers of anaerobic gram-positive cocci and rods decreased in most subjects during ampicillin treatment but were normalized within 2 weeks. Bacteroides strains were recovered in higher numbers in the lactic acid producing bacteria group compared to the placebo group. The volunteers receiving lactic acid producing bacteria were recolonized slightly faster than those having placebo. There were adverse effects observed in 3 subjects receiving ampicillin plus placebo. In the lactic acid producing bacteria group, one subject had diarrhoea on day 3 to on day 3 to day 7.

Discovering lactic acid bacteria by genomics

“…It is a leading member of the probiotic bacteria due to numerous studies that have provided a growing body of evidence for its role in a myriad of potential health benefits. These include diarrhea prevention in antibiotic treated patients (Black et al 1991), cholesterol reduction (Dambekodi & Gilliland 1998), alleviation of lactose intolerance symptoms (Jiang et al 1996), immune stimulation (Takahashi et al 1998), and cancer prevention (Reddy & Rivenson 1993). This myriad of potential health benefits attributed to the B. longum species clearly illustrates that this species possesses many very interesting characteristics.…”

Effects of broad-spectrum antibiotics on colonization of gastrointestinal tracts of mice by Candida albicans

“…Amoxicillinclavulanate and chloramphenicol have been reported to cause substantial increases in GI colonization by yeasts (4,19), while ciprofloxacin was associated with modest or small increases (7,8,16). Also, sulfamethoxazole-trimethoprim (1,5,6) and ampicillin (2,17) have been found to promote colonization of the GI tract by yeasts.…”

The Clinical Potential of Linex Forte® in Systemic Antibiotic Therapy

“…lactis (BB-12) и Lactobacillus acidophilus (LA-5) в отношении ААД [50][51][52]. Так, в рандомизированном плацебо-контро-лируемом исследовании с участием 343 пациентов было показано, что комбинация пробиотиков LA-5 и BB-12 достоверно уменьшает риск возникновения ААД по срав-нению с плацебо (частота ААД составляла 10,8% в группе пробиотика и 15,6% в группе плацебо (p = 0,19)), а в слу-чае ее развития способствует сокращению продолжи-тельности ААД в 2 раза и уменьшению ее тяжести [50].…”