Effect of Lactobacillus acidophilus strain L-55 on the development of atopic dermatitis-like skin lesions in NC/Nga mice

Sunada, Yosuke; Nakamura, Syoji; Kamei, Chiaki

doi:10.1016/j.intimp.2008.08.011

Cited by 31 publications

(24 citation statements)

References 42 publications

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“…The NC/Nga stain of mice has been shown to develop AD-like skin lesions following repeated applications of TNCB [10,30,33]. In accordance with this previous finding, the clinical skin severity in the positive control group in the present study increased gradually depending on the number of challenges with TNCB (Fig.…”

Section: Effects Of Oral Administration Of Paramylon On Development Osupporting

confidence: 91%

“…Furthermore, Matsumoto et al suggested that defective production of IFN- by T cells less sensitive to IL-12 and low responsiveness of B cells to IFN-contrib-ute to IgE hyperproduction in NC/Nga mice [23]. The results of the present study indicated that hapten-induced NC/Nga mice model created by repeated application of TNCB showed similar changes of Th1/Th2 cytokines to those of spontaneous NC/Nga mice model [10,30,33].…”

Section: Discussionsupporting

confidence: 64%

“…Recently it has also been reported that NC/ Nga mice develop AD-like skin lesions after repeated application of hapten such as 2,4,6-trinitrochlorobenzene (TNCB) and 2,4-dinitrofluorobenzene (DNFB) under SPF condition [10,30,33,39]. The elevation of plasma levels of total IgE has been reported to correlate with the appearance of the AD-like lesion in NC/Nga mice, with massive infiltration of CD4+ T cells producing IL-4 and IL-5, and the degranulation of mast cells and eosinophils [22].…”

Section: Z Inhibits Development Of Atopic Dermatitis-like Skin Lesionmentioning

confidence: 99%

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Oral Administration of Paramylon, a .BETA.-1,3-D-Glucan Isolated from Euglena gracilis Z Inhibits Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

Sugiyama

Hata

Suzuki³

et al. 2010

J. Vet. Med. Sci.

101

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ABSTRACT. Paramylon is a -1,3-D-glucan isolated from Euglena gracilis Z. This study was designed to evaluate the suppressive effects of the oral administration of paramylon on the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of 2,4,6-trinitrochlorobenzene (TNCB) in sensitized NC/Nga mice. The effects of paramylon were assessed by measuring macroscopical and histopathological findings of skin, ear swelling, serum levels of total IgE, interleukin-4 (IL-4) and interferon- (IFN-) and IL-18 and IL-12 contents in the skin lesions. Oral administration of paramylon inhibited the development of AD-like skin lesions as exemplified by a significant decrease in dermatitis scores for the back, ear swelling and hypertrophy of the skin, infiltration of inflammatory cells in the skin, and serum IgE levels. Oral administration of paramylon reduced serum levels of both IL-4 and IFN- and IL-18 and IL-12 contents in the skin lesions. Oral administration of paramylon did not cause weight loss, as was observed with prednisolone. These results suggest that paramylon inhibits the development of AD-like skin lesions in NC/Nga mice by suppressing both the T-helper (Th) 1 and Th 2 cell responses. Our results indicate that paramylon treatment could provide an effective alternative therapy for the management of AD.KEY WORDS: atopic dermatitis, -1,3-D-glucan, interferon-, interleukin-4, paramylon.

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Section: Effects Of Oral Administration Of Paramylon On Development Osupporting

confidence: 91%

Section: Discussionsupporting

confidence: 64%

Section: Z Inhibits Development Of Atopic Dermatitis-like Skin Lesionmentioning

confidence: 99%

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Oral Administration of Paramylon, a .BETA.-1,3-D-Glucan Isolated from Euglena gracilis Z Inhibits Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

Sugiyama

Hata

Suzuki³

et al. 2010

J. Vet. Med. Sci.

101

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“…48 Similarly, Lactobacillus acidophilus suppressed the development of atopic dermatitis-like skin lesions in sensitized NC/Nga mice via decreasing serum total IgE level. 56 A final study showed that the administration of either Bifidobacterium lactis or LGG suppressed antigen-specific IgE production too. 57 Atopic dermatitis-like skin lesions were induced by repeated challenges with mostly picrylchloride in the Th2-skewed NC/Nga mouse strain.…”

Section: R E T R a C T E Dmentioning

confidence: 99%

RETRACTED: Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders: An Up-to-Date Literature Review of Essential Experimental and Clinical Data

Özdemir

2012

J Evid Based Complementary Altern Med

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“Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders: An Up-to-Date Literature Review of Essential Experimental and Clinical Data,” by Öner Özdemir, Journal of Evidence-Based Complementary & Alternative Medicine, April 2013 (18:2), doi: 10.1177/2156587212461279 .This article has been retracted due to unattributed overlap with material from other sources and due to duplicate publication.The unattributed excerpts in the article were taken from the following sources: Ouwehand AC. Antiallergic effects of probiotics. J Nutr. 2007;137(3 suppl 2):794S–797S. Saavedra JM. Use of probiotics in pediatrics: rationale, mechanisms of action, and practical aspects. Nutr Clin Pract. 2007;22:351–365. doi:10.1177/0115426507022003351. Rook GA, Brunet LR. Microbes, immunoregulation, and the gut. Gut. 2005;54:317–320. doi:10.1136/gut.2004.053785. Michail S. The role of probiotics in allergic diseases. Allergy Asthma Clin Immunol. 2009;5:5. doi:10.1186/1710-1492-5-5. The author also published the following works that include significant unattributed excerpts from the article: Özdemir Ö, Erol AY. Preventative and therapeutic probiotic use in allergic skin conditions: experimental and clinical findings. BioMed Res Int. 2013;2013:932391. doi:10.1155/2013/932391. Özdemir Ö. The role of probiotics in atopic dermatitis prevention and therapy. In: Esparza-Gordillo J, Dekio I, eds. Atopic Dermatitis: Disease Etiology and Clinical Management. Rijeka, Croatia: InTech; 2012:353–386. doi:10.5772/25301.

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“…L. acidophilus strain L-55, which was isolated from healthy infant feces (3, 4), has tolerance to gastrointestinal conditions and a high ability to adhere to Caco-2 cells (3, 4), and it has been used as a starter culture for commercial dairy products (3). It has also been reported that L. acidophilus L-55 has the effect of alleviating the symptoms of allergic rhinitis (3, 5) and atopic dermatitis (4). …”

Section: Genome Announcementmentioning

confidence: 99%

Draft Genome Sequence of Probiotic Lactobacillus acidophilus Strain L-55 Isolated from a Healthy Human Gut

et al. 2016

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Effect of Lactobacillus acidophilus strain L-55 on the development of atopic dermatitis-like skin lesions in NC/Nga mice

Cited by 31 publications

References 42 publications

Oral Administration of Paramylon, a .BETA.-1,3-D-Glucan Isolated from Euglena gracilis Z Inhibits Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

Oral Administration of Paramylon, a .BETA.-1,3-D-Glucan Isolated from Euglena gracilis Z Inhibits Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

RETRACTED: Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders: An Up-to-Date Literature Review of Essential Experimental and Clinical Data

Draft Genome Sequence of Probiotic Lactobacillus acidophilus Strain L-55 Isolated from a Healthy Human Gut

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