Effect of Lactoferrin on Paraoxonase Activity, Some Acute Phase Proteins and Oxidant/Antioxidant System

Abstract

Lactoferrin is a member of the high affinity to glycoprotein family of transferrin for iron and plays a role in natural immunity as well as antibacterial, antifungal, antiviral, antiparasitic, antioxidant, anticancer, antiinflammatory, bone health and immunomodulation. The aim this study was to investigate of the acute effect of lactoferrin on paraoxonase activity, oxidant/antioxidant system and total protein, albumin and globulin. This study was carried out on 6-month Sprague Dawley rats in a total number of 20 subjects. Paraoxonase activity, total antioxidant capacity (TAC), total oxidant capacity (TOC), total protein, albumin and globulin levels were measured through the spectrophotometer. When the lactoferrin group was compared with the control group, it was found that TAC levels were statistically higher (P<0.05), TOC levels were statistically lower (P<0.01) and paraoxonase activity was statistically higher (P<0.05). There was no difference in total protein and globulin levels in the lactoferrin group compared to the control group. As a result, acute lactoferrin administration may play an important role in the regulation of antioxidant balance by increasing paraoxonase activity and decreasing the level of reactive oxygen species.