2006
DOI: 10.2527/jas.2005-544
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Effect of lactoferrin on the growth performance, intestinal morphology, and expression of PR-39 and protegrin-1 genes in weaned piglets1

Abstract: A total of 90 weaned female pigs (Duroc x Landrace x Yorkshire) were used in a 15-d growth experiment to investigate the effect of lactoferrin on growth performance, intestinal morphology, and expression of PR-39 and protegrin-1 genes. The pigs were allocated on the basis of BW and litter to 3 dietary treatments in a randomized complete block design. There were 3 replicate pens per treatment, and the pigs were grouped with 10 pigs per pen. The dietary treatments were (1) basal diet; (2) basal diet + 20 mg of f… Show more

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Cited by 75 publications
(55 citation statements)
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“…This result also shows that the activity of lactoferrin in vivo may be similar to that demonstrated by Oguchi et al [9] in vitro. Similar results were obtained by Wang et al [38] in his study of pigs supplemented with 1 g/kg lactoferrin. Although, the villi in group CL are only slightly longer than villi of group Ci, without statistical significance, this result proves more consistent with the findings from the literature, which clearly demonstrates that there are highly effective mechanisms for maintaining the homeostasis of the intestinal epithelium [28][29][30].…”
Section: Histomorphometry Of the Intestinal Mucosasupporting
confidence: 80%
“…This result also shows that the activity of lactoferrin in vivo may be similar to that demonstrated by Oguchi et al [9] in vitro. Similar results were obtained by Wang et al [38] in his study of pigs supplemented with 1 g/kg lactoferrin. Although, the villi in group CL are only slightly longer than villi of group Ci, without statistical significance, this result proves more consistent with the findings from the literature, which clearly demonstrates that there are highly effective mechanisms for maintaining the homeostasis of the intestinal epithelium [28][29][30].…”
Section: Histomorphometry Of the Intestinal Mucosasupporting
confidence: 80%
“…A lactoferrina, além de aumentar a altura das vilosidades, também reduz a profundidade das criptas quando adicionada em dietas de leitões (Wang et al, 2006). Adicionalmente, esse metabólito possui outras funções fisiológicas, como proteção contra infecções intestinais (Dial et al, 1998) e regulação da função imune (Lee, 1998 (Wang et al, 2006e Shan et al, 2007.…”
Section: Resultsunclassified
“…A lactoferrina, além de aumentar a altura das vilosidades, também reduz a profundidade das criptas quando adicionada em dietas de leitões (Wang et al, 2006). Adicionalmente, esse metabólito possui outras funções fisiológicas, como proteção contra infecções intestinais (Dial et al, 1998) e regulação da função imune (Lee, 1998 (Wang et al, 2006e Shan et al, 2007. A proibição pela União Europeia do uso de antibióticos como promotores de crescimento em dietas para leitões a partir de 1997 intensificou as pesquisas na busca de novas alternativas (Casewell et al, 2003).…”
Section: Resultsunclassified
See 1 more Smart Citation
“…In our previous study, we investigated effect of lactoferrin on growth performance, intestinal morphology, and expression of PR-39 and protegrin-1 genes in weaned piglets (Wang et al, 2006), and exploited the silkworm, Bombyx mori, as host for the recombinant baculovirus harboring the porcine lactoferrin (PLF) gene to produce the recombinant PLF (rPLF) (Wang et al, 2005a). In addition, we evaluated the developmental gene expression of lactoferrin (LF) and the effect of supplementary iron on gene expression of LF in the mammary gland of mice, which demonstated that iron significantly increased LF mRNA on d 1 and 25 of lactation (Wang et al, 2005b).…”
Section: Discussionmentioning
confidence: 99%