Effect of Lanthanum Zirconate Ceramic on the Dynamics of Hematological Parameters and the Bone Remodeling Markers: Experimental Study

Abstract

The aim. To study the effect of a new ceramic material based on lanthanum zirconate (LZ) on the dynamics of hematological parameters and markers of bone tissue remodeling after intramedullary osteosynthesis (IO) of a hip fracture with a LZ rods in experiment.
 Material and methods. The ceramic material La1.95Ca0.05Zr2O7 was used. The experiment was carried out on guinea pigs, which were divided into 4 groups: the main group - modeling of a hip fracture, IO of fracture with LZ rod (n = 9), the comparison group - modeling of a hip fracture, IO of a fracture with a rod from -tricalcium phosphate (TCP ) (n = 9), control (C) - modeling of a hip fracture without IO (n = 9), native control (NC). Animals were withdrawn from the experiment before surgery (NC), 4, 10 and 25 weeks after surgery (n = 3 for each time point). Hematological parameters, a tartrate-resistant acid phosphatase (TRAP) as osteoresorption marker, osteocalcin (OC) as osteogenesis marker, were determined.
 Results. Red blood cell count in all groups of operated animals at 4, 10 and 25 weeks after surgery did not differ significantly from the NK group. A significantly higher level of leukocytes in comparison with other groups was observed in the control group 10 weeks after surgery (p=0.044), which is explained by the absence of fracture synthesis. The platelet level in all groups of operated animals during the study period did not differ significantly from the NK group. The TRAP activity in the LZ and TCP groups had maximum values ​​after 4 weeks, the OC level reached a maximum by 10 weeks after the operation without significant differences between LZ and TCP groups of animals.
 Conclusion. Study of the main hematological parameters did not reveal a negative effect of LZ on experimental animals; a positive effect of this material on the process of bone tissue remodeling was found. A new ceramic material based on lanthanum zirconate appears to be promising for use in traumatology and orthopedics.

Ceramic materials based on lanthanum zirconate for the bone augmentation purposes: cytocompatibility in a cell culture model

“…Doping with calcium promotes the synthesis of osteopontin, which is involved in bone formation and promotes cell attachment and proliferation on the implant surface [15]. The calcium-doped lanthanum zirconate demonstrates positive results in the process of bone remodeling and repair [16,17]. The introduction of strontium into osteogenic materials is also considered promising [18].…”