Effect of latamoxef on platelet function and prothrombin time in partially nephrectomized rats.

Abstract

Abstract-Latamoxef(daily 100 and 300 mg/kg, i.v.) was injected once a day for 8 days to 75% and 90% nephrectomized

Vitamin K-reversible hypoprothrombinemia in rats. I. Sex differences in the development of hypoprothrombinemia and the effects of beta-lactam antibiotics.

“…Administration of NMTT itself produced the same effect as its parent anti biotics (6)(7)(8)13). Interestingly, the in vivo effects were also observed when CEZ or CTZ were administered ( (Table 1).…”

“…(1)(2)(3)(4)(5). Subsequent studies demonstrated that the antibiotics-induced hypoprothrombinemia was manifested only in vitamin K-deficient animals and not in rats fed an ordinary diet (6)(7)(8). These results suggest a close corre lation of vitamin K metabolism with the development of adverse effects of antibiotics on the blood coagulation system.…”

“…When rats were maintained on the ordinary diet containing a sufficient amount of vitamin K, these antibiotics caused no hypo prothrombinemic changes in blood coagu lation parameters, suggesting that the bio synthetic reaction of blood clotting factors is not modified by the antibiotics when a sufficient amount of vitamin K is present. Several investigators found no inhibition of liver microsomal gamma-glutamylcarboxyl ase, an essential enzyme for the biosynthesis of blood coagulation factors, in rats treated with the NMTT-containing antibiotics (6)(7)(8)24). These results support the above as sumption.…”

Synthesis of thromboxane receptor antagonists with bicyclo[3.1.0]hexane ring systems

“…dZ-( 1/3,5/3)-2-(Phenylsulfonyl)-3-hydroxy-6a,7a-epoxy-2azabicyclo [3.3.0]octane (25). IR (CHClg) 3360,1325,1155 Hz), 5.38-5.67 (1 H, m), 7.36-7.65 (3 H, m), 7.75-8.05 (2 H, m).…”

“…Epoxidation of 28 proceeded from the sterically less hindered side and compound 29 was obtained as the sole product. These compounds 25 and 29 were also converted to 26a,b and 27 or 30a,b and 31, respectively, by the procedure described for the conversion of 10 to 11a,b and 12.…”