Effect of latent iron deficiency on GABA and glutamate neuroreceptors in rat brain

Abstract

Eight weeks of latent iron deficiency in weaned female rats of Sprague Dawley strain maintained on experimental low-iron diet (18-20 mg/kg) did not significantly change the gross bodyweight and tissue weights of brain and liver. Packed cell volume (PCV) and hemoglobin concentration remained unaltered. However, non-heme iron content in liver and brain decreased significantly (p< 0.001 )o The activities of glutamate dehydrogenase, glutamic acid decarboxylase, and GABA-transaminase (GABA-T) in brain decreased by 15%, 11.4% and 25.7% respectively. However, this decrease was not statistically significant. Binding of 3H Muscimol at pH 7.5 and 1 mg protein/assay increased by 143% (p< 0.001 ) in synaptic vesicular membranes from iron-deficient rats as compared to the controls. 3H glutamate binding to the synaptic vesicles was also carried out under similar condition. However, the L-glutamate binding was reduced by 63% in the vesicular membranes of iron deficient animals. These studies indicate that iron plays important functional role in both excitatory and inhibitory neurotransmitter receptors.

Iron deficiency anaemia: Effect on congnitive development in children: A review

“…Most of the co-relational and experimental studies done earlier confirmed the hypothesis that iron deficiency of mild to moderate nature has an adverse effect on congnitive development (3,7). Therefore, it may be logical to suggest that impairment of higher mental function like cognition and learning in humans (5, 13) may be linked to changes in neurotransmitter receptors and consequent signal transduction process in the nervous system (28,29).…”

“…A significant decrease in non heme iron both in liver and brain without changes in hematocrit are observed and they clearly suggest appreciable decrease in content of iron in certain tissue. The significant effects on neurotransmitter receptors during early stages of iron deficiency indicate the deficits in both excitatory and inhibitory pathways of central nervous system (28). The neurotransmitter receptors remain in dynamic equilibrium and their regulation depends on the synthesis, metabolism and various other components in signal transduction cascade.…”

Loss of divalent metal transporter 1 function promotes brain copper accumulation and increases impulsivity

“…In addition, increased GABA in the brain, including hippocampus, is found in both iron‐deficient anemia (Batra and Seth ; Mittal et al . ; Rao et al . ) and hypoxia (Madl and Royer ), but hippocampal GABA levels in b/b rats were decreased.…”

Hubungan Kadar Hemoglobin dengan Kejang Demam Pada Anak Usia Balita

“…9,10 Kejang terjadi apabila terdapat depolarisasi berlebihan pada neuron dalam sistem saraf pusat dan jika kondisi ini berada pada level yang tetap dan mendapat rangsangan yang kuat seperti demam tinggi (>38 0 C) dan kondisi anemia. 9,11,12 Berdasarkan penelitian yang dilakukan Khanis 13 didapatkan hasil uji statistik menunjukkan adanya perbedaan pada distribusi kejadian penurunan kadar Hb antara kelompok kasus (kejang demam) dengan kontrol (demam tanpa kejang).…”