Effect of lavender essential oil as a prophylactic therapy for migraine: A randomized controlled clinical trial

Rafie, Shahram; Namjoyan, Forough; Golfakhrabadi, Fereshteh; Yousefbeyk, Fatemeh; Hassanzadeh, Alireza

doi:10.1016/j.hermed.2016.01.003

Cited by 34 publications

(34 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In traditional Iranian medicine, basil is used as a sedative and analgesic drug [28]. Previous studies on the impact of other herbal medication on controlling migraine headaches have brought up similar results [10, 23]. An in vivo study by Abdolmaleki et al [45] shows that the analgesic and anti-inflammatory effects of peppermint depend on dosage [41], and since basil has the same family as peppermint, this would apply to basil as well.…”

Section: Discussionmentioning

confidence: 99%

“…Cineole, geraniol, flavonoids, and estragole have anti-inflammatory properties [45-49]. Extract of chamomile [50], rose [10], lavender [23], and Lippia alba [51] also contain anti-inflammatory properties which can help relieve migraine symptoms. The spasmolytic effect of menthol as a part of basil essential oil can reduce the sensitivity of the pre-cranial muscles; therefore, it may lessen migraine pain [52].…”

Section: Discussionmentioning

confidence: 99%

“…CAM has lesser-known side effects with fewer dependency on medication [17]. Existing literature shows promising effectiveness for the treatment of migraines [10,[18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study

et al. 2020

View full text Add to dashboard Cite

Objective: Complementary therapies have been increasingly used for the prevention and treatment of migraine so that there is a need for studies in this setting. This study sought to determine the effects of basil essential oil on the severity and frequency of migraine attack headaches. Methods: A triple-blind clinical trial study was performed on 144 patients diagnosed with migraine. Patients were randomly allocated by a stratified method to four groups of 36 titled basil essential oil 2, 4, 6%, and placebo groups. Medications were used topically every 8 h for 3 successive months. In addition, each individual received 325 mg of acetaminophen every 12 h. The severity and frequency of migraine attacks were measured prior to the study, at weeks 2, 4, 8, and 12. The visual analog scale was used to measure pain intensity. The marginal model and generalized estimation equations were used to compare changes in the intensity and frequency of pain over time. Results: The interaction of the dose and time factors was significant on both pain intensity (p < 0.001) and frequency of attack (p < 0.001). The odds ratio of higher pain intensity and rate ratio of higher frequency of attack in the intervention groups compared to the placebo group were decreased over the study time. Conclusion: Time lapse and higher doses of basil essential oil would reduce both the intensity and frequency of migraine attacks.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…They are also used in aromatherapy. Inhalation of their volatile compounds is reported to relieve the symptoms of stress, exhaustion, migraines, anxiety, insomnia, and depression . Normally, essential oils of Lavandula plants are obtained from two major species: L. angustifolia Mill .…”

Section: Introductionmentioning

confidence: 99%

“…Inhalation of their volatile compounds is reported to relieve the symptoms of stress, exhaustion, migraines, anxiety, insomnia, and depression. [4] Normally, essen-tial oils of Lavandula plants are obtained from two major species: L. angustifolia MILL. and L. stoechas L. Essential oil of L. angustifolia is often used in the fragrance industry [5] while the essential oil of L. stoechas is primarily used as a therapeutic agent.…”

Section: Introductionmentioning

confidence: 99%

Essential Oil Compositions and Antibacterial and Antioxidant Activities of Five Lavandula stoechas Cultivars Grown in Thailand

Insawang

Pripdeevech

Tanapichatsakul

et al. 2019

Chemistry & Biodiversity

View full text Add to dashboard Cite

The essential oils of five Lavandula stoechas cultivars grown in Thailand were characterized for their volatile compounds using GC‐FID and GC/MS methods as well as screened for antibacterial and antioxidant activities. Dried aerial parts, including flowers and stems from each cultivar, were subjected to hydrodistillation for 4 h. The essential oil yields were 0.18 %–0.82 % w/w. Of the 95 compounds detected and identified, 1,8‐cineole, fenchone, and camphor were considered the major compounds. Essential oil from each cultivar demonstrated different patterns of antibacterial activity and a variety of antioxidant properties. The highest antibacterial activity, MIC=0.39 mg mL−1, was observed from the essential oil of L. stoechas ‘major’ (against Klebsiella pneumoniae and Salmonella typhimurium) and the essential oil of L. stoechas ‘white lavender’ (against S. typhimurium). The essential oil of L. stoechas×viridis ‘St. Brelade’ possessed the highest antioxidant capacity, as determined by the DPPH and ABTS assays (IC50 of 67.65 and 89.26 mg mL−1, respectively). The results indicated that some of these essential oils could be used as key ingredients in lavender oil products in Thailand to increase their therapeutic efficacy, depending on their intended application.

show abstract

Weighing paper‐assisted magnetic ionic liquid headspace single‐drop microextraction using microwave distillation followed by gas chromatography–mass spectrometry for the determination of essential oil components in lavender

Chen

Liu

Wang

et al. 2020

J of Separation Science

View full text Add to dashboard Cite

Weighing paper‐assisted magnetic ionic liquid headspace single‐drop microextraction using microwave distillation followed by gas chromatography–mass spectrometry was successfully developed to determine the essential oil components in lavender. The magnetic ionic liquid 1‐octyl‐3‐methylimidazolium tetrachloroferrate was successfully synthesized and used as the optimal extraction solvent. An aliquot of 9 μL of magnetic ionic liquid could be stably suspended on the weighing paper for long time extraction. The increase of the extractant volume resulted in a significantly enhanced in extracting efficiency of the weighing paper‐assisted magnetic ionic liquid headspace single‐drop microextraction than traditional headspace single‐drop microextraction method. In this experiment, the optimal conditions were 1‐octyl‐3‐methylimidazolium tetrachloroferrate as the extraction solvent, extraction time of 12 min, microwave power of 600 W, cyclohexane as back‐extractant and sample amount of 30 mg. The developed method was successfully applied to analyze 16 lavender samples from three different harvest years. A total of 39 compounds in lavender were identified and the principal component analysis provided a clear separation between those lavender samples harvested in different years. The results indicated that the proposed weighing paper‐assisted magnetic ionic liquid headspace single‐drop microextraction is a novel, fast, simple and sensitive microextration technique for the determination of the essential oil components in lavender.

show abstract

Effect of lavender essential oil as a prophylactic therapy for migraine: A randomized controlled clinical trial

Cited by 34 publications

References 27 publications

The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study

The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study

Essential Oil Compositions and Antibacterial and Antioxidant Activities of Five Lavandula stoechas Cultivars Grown in Thailand

Weighing paper‐assisted magnetic ionic liquid headspace single‐drop microextraction using microwave distillation followed by gas chromatography–mass spectrometry for the determination of essential oil components in lavender

Contact Info

Product

Resources

About