Effect of left bundle branch block on diastolic function in dilated cardiomyopathy.

Xiao, Han; Lee, C H; Gibson, D G

doi:10.1136/hrt.66.6.443

Cited by 206 publications

(102 citation statements)

References 9 publications

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“…The mechanical consequences of dyssynchrony include suboptimal ventricular filling, a reduction in LV dP/dt (rate of rise of ventricular contractile force or pressure), prolonged duration (and therefore greater severity) of mitral regurgitation, and paradoxical septal wall motion. [182][183][184] Ventricular dyssynchrony has also been associated with increased mortality in HF patients. [103][104][105] Dyssynchronous contraction can be addressed by electrically activating the right and left ventricles in a synchronized manner with a biventricular pacemaker device.…”

Section: Cardiac Resynchronization Therapymentioning

confidence: 99%

2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults

Jessup¹,

Abraham²,

Casey³

et al. 2009

Circulation

1,319

538

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Section: Cardiac Resynchronization Therapymentioning

confidence: 99%

2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults

Jessup¹,

Abraham²,

Casey³

et al. 2009

Circulation

1,319

538

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“…7 In another report, cardiac function improved after catheter ablation in a patient with type B Wolff-Perkinson-White syndrome with an old inferior myocardial infarction. 8 Thus, the asynergic wall motion caused by LBBB might cause the decreasing cardiac function observed in some cases.…”

Section: Discussionmentioning

confidence: 99%

A Case of Cardiomyopathy Induced by Premature Ventricular Complexes.

Shiraishi¹,

Ishibashi²,

Urao³

et al. 2002

Circ J

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ong-lasting tachyarrhythmia can result in wall motion abnormality, which is reversible if the culprit arrhythmia is treated. 1-3 Frequent isolated premature ventricular complexes (PVCs) in the absence of tachycardia can cause left ventricular (LV) dysfunction, 4,5 but this phenomenon has rarely been documented. We report resolution of apparent dilated cardiomyopathy (DCM) in a patient after the focal source of PVCs was eliminated by radiofrequency catheter ablation (RF-CA). Case ReportA 53-year-old man presented with palpitations and exertional fatigue, but without clinical or laboratory evidence of ischemic heart disease. He was diagnosed by echocardiography as having DCM with fractional shortening (FS) of the left ventricle of 25%. All 4 chambers were dilated: LV diastolic diameter 65 mm, LV systolic diameter 49 mm, and left atrial diameter 46 mm. The chest X-ray showed mild cardiomegaly (cardio thoracic ratio) (CTR) 54%, and the serum brain natrinvetic peptide (BNP) level was mildly elevated to 54 pg/ml. The electrocardiogram (ECG) did not record any abnormal findings other than frequent PVCs. Repeated Holter recordings revealed about 50,000 isolated or couplet PVCs in a 24-h period, the majority with a uniform left bundle branch block (LBBB) pattern and inferior-axis morphology. PVCs bigeminy appeared constantly throughout the day. During an exercise test, the number of PVCs decreased with the loading of exercise and increased again after the test. Tl-myocardial scintigraphy showed a mildly decreased uptake in the apicoanteroseptal wall. Cardiac magnetic resonance imaging did not show evidence of infiltration of fatty tissue.

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“…Ventricular dyssynchrony appears to have a deleterious impact on the natural history of heart failure, as a wide QRS complex has been associated with increased mortality in patients experiencing heart failure. [13][14][15] On the basis of these observations, investigators hypothesized that patients with LV dysfunction and delayed ventricular conduction would benefit from pacing at sites that achieve a more rapid ventricular depolarization and thus a more synchronous contraction, or result in a more favorable contraction pattern, and correct interatrial and/or interventricular conduction delays to maintain optimal atrial-ventricular (AV) synchrony. Shortening activation might also prolong the time available for myocardial perfusion.…”

Section: Rationale For Cardiac Resynchronization Therapymentioning

confidence: 99%