Effect of Left Ventricular Scar Size, Location, and Transmurality on Left Ventricular Remodeling With Healed Myocardial Infarction

Ørn, Stein; Manhenke, Cord; Anand, Inder S.; Squire, Iain B.; Nagel, Eike; Edvardsen, Thor; Dickstein, Kenneth

doi:10.1016/j.amjcard.2006.11.059

Cited by 142 publications

(62 citation statements)

References 18 publications

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“…IS is a prognostic indicator after an AMI 3–7 24 – 26. In a previous report, IS assessed by CMR enhancement was found to be more sensitive than by SPECT defect, especially for smaller infarcts 27.…”

Section: Discussionmentioning

confidence: 93%

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Comparison of delayed enhancement patterns on multislice computed tomography immediately after coronary angiography and cardiac magnetic resonance imaging in acute myocardial infarction

Habis

Capderou

Sigal-Cinqualbre

et al. 2008

Heart

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Section: Discussionmentioning

confidence: 93%

“…Left ventricular remodelling and its deleterious consequences are predicted by transmurality extent1 2 and IS 3 – 5. Preliminary studies have also demonstrated a correlation between infarct (but not the myocardium at risk) size assessed by technetium-99m sestamibi and mortality 6 7.…”

mentioning

confidence: 99%

Comparison of delayed enhancement patterns on multislice computed tomography immediately after coronary angiography and cardiac magnetic resonance imaging in acute myocardial infarction

Habis

Capderou

Sigal-Cinqualbre

et al. 2008

Heart

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“…Infarct size is a major determinant of adverse LV remodeling post-MI [16,29] and, together with parameters of LV remodeling, is an important predictor of adverse CV events [30,31,32]. Although Gal-3 predicts morbidity and mortality in HF populations, no clear association between LV anatomy and systolic function (evaluated by echocardiography) and Gal-3 has been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Circulating Galectin-3 Levels Are Increased in Patients with Ischemic Heart Disease, but Are Not Influenced by Acute Myocardial Infarction

Singsaas

Manhenke²,

Dickstein³

et al. 2016

Cardiology

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Objectives: Galectin-3 (Gal-3) is involved in cardiac inflammation and fibrosis, and is in use as a biomarker that indicates increased risk in heart failure. This study examined the relationship between Gal-3 levels and acute and old myocardial infarction (MI) in patients assessed by cardiac magnetic resonance (CMR) imaging. Methods: Group 1 consisted of 38 patients with ST-elevation MI and single-vessel disease treated with primary percutaneous coronary intervention (PCI). Group 2 consisted of 52 patients with prior complicated MI. Twenty-two controls were included. CMR was performed in group 1 at 2 days, 1 week, 2 months and 1 year following PCI and in group 2 at >4 years after MI. Results: Median Gal-3 was elevated in patients compared with controls, group 1: 11.93 ng/ml (IQR 6.34-17.52, p = 0.03), group 2: 12.96 (IQR 6.33-19.29, p = 0.03) and controls: 10.16 (IQR 5.59-14.73). Gal-3 levels did not change during acute MI, and there was no relationship between Gal-3 and infarct size, troponin-T, high-sensitivity C-reactive protein, left-ventricular (LV) volumes or LV ejection fraction (LVEF) in group 1. In group 2, Gal-3 correlated modestly with MI size (r = 0.28, p < 0.05), LV end-diastolic volume index (r = 0.40, p < 0.01), LV end-systolic volume index (r = 0.43, p < 0.01) and LVEF (r = -0.39, p < 0.01). Conclusion: There was no relationship between Gal-3 levels and acute ischemic myocardial injury. A significant, modest relationship between Gal-3 levels, MI size and LV remodeling was only found in patients with old MI.

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“…Aging-Related Defects That Influence Post-MI Healing ages between 61 and 69 years (10,11). Elderly patients are at greater risk after reperfused STEMI (5,9).…”

Section: Figurementioning

confidence: 99%

Aging and Defective Healing, Adverse Remodeling, and Blunted Post-Conditioning in the Reperfused Wounded Heart⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.

Jugdutt

Jelani

2008

Journal of the American College of Cardiology

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Effect of Left Ventricular Scar Size, Location, and Transmurality on Left Ventricular Remodeling With Healed Myocardial Infarction

Cited by 142 publications

References 18 publications

Comparison of delayed enhancement patterns on multislice computed tomography immediately after coronary angiography and cardiac magnetic resonance imaging in acute myocardial infarction

Comparison of delayed enhancement patterns on multislice computed tomography immediately after coronary angiography and cardiac magnetic resonance imaging in acute myocardial infarction

Circulating Galectin-3 Levels Are Increased in Patients with Ischemic Heart Disease, but Are Not Influenced by Acute Myocardial Infarction

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