Effect of lentinan on membrane-bound protein expression in splenic lymphocytes under chronic low-dose radiation

Liu, Yinghua; Ma, Shou-Dong; Fu, Qingjie; Zhao, Liang; Li, Yang; Wang, Haiqing; Li, Mingchun

doi:10.1016/j.intimp.2014.07.027

Cited by 7 publications

(1 citation statement)

References 22 publications

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“…Lentinan is a well-recognized immunomodulator, which is extracted from shiitake (8). AECOPD medications include bronchodilator, anti-infective drugs as required and systemic cortical hormone, but systemic corticosteroid treatment has obvious adverse effects, including hyperglycemia, osteoporosis and vertebral compression fractures.…”

Section: Introductionmentioning

confidence: 99%

Clinical effects of lentinan combined with budesonide inhalation in treating acute exacerbation of chronic obstructive pulmonary disease under mechanical ventilation

Sun

Zhao

2019

Exp Ther Med

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In the present study, the clinical efficacy of the immune modulator lentinan combined with inhalation of the corticosteroid budesonide in treating acute exacerbation of chronic obstructive pulmonary disease (AECOPD) under mechanical ventilation was assessed. A total of 72 cases of AECOPD treated at Shanghai Jiao Tong University Affiliated Sixth People's Hospital (Shanghai, China) between June 2016 and September 2017 were enrolled. The AECOPD patients were randomly divided into an experimental group (n=36) and a control group (n=36). All of the patients received ventilator support and endotracheal intubation was performed. The experimental group was orally administered lentinan and budesonide was administered via atomization inhalation through a Y-tube and the control group received only budesonide via Y-tube. After the treatment, airway pressure, the time of mechanical ventilation and the time of stay at the intensive care unit for the experimental group were significantly lower than those for the control group (P<0.001). The plasma levels of adiponectin, D-dimer, interleukin-17 and high-sensitivity C-reactive protein, as well as the pressure of CO 2 in the experimental group were significantly lower than those in control group (P<0.001). Furthermore, the partial O 2 pressure in the experimental group was significantly higher than that in the control group (P<0.001). After the combined treatment, the proportions of CD3 + and CD4 + T-cells in the blood were elevated, while the proportion of CD8 + T-cells was decreased, compared with those in the experimental group at baseline or the control group post-treatment. In conclusion, the strategy of lentinan treatment combined with budesonide inhalation for AECOPD patients under mechanical ventilation demonstrated improved clinical efficacy compared with budesonide alone. (Chinese Clinical Trial Registry no. ChiCTR1800019088).

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Section: Introductionmentioning

confidence: 99%

Clinical effects of lentinan combined with budesonide inhalation in treating acute exacerbation of chronic obstructive pulmonary disease under mechanical ventilation

Sun

Zhao

2019

Exp Ther Med

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Research Progress on Biological Activities of Polysaccharides from Edible Fungus

et al. 2023

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Edible fungus is widely eaten because of their delicious taste and high nutritional value. Growing evidence indicates that edible fungus is rich in various active ingredients including polysaccharides, proteins, fats, vitamins, and other ingredients. Polysaccharides are one of the main active ingredients of edible fungi. Increasing research has confirmed that edible fungus polysaccharides (EFPs) show multiple biological activities such as antioxidant, anti-inflammatory, anti-tumor, immune regulation, anti-virus, gut microbiota regulation, hypoglycemic, etc. Hence, EFP related research has received more and more attention due to their non-toxic, high medical, and nutritional values. This paper reviews the latest research progress of EFPs biological activities, and looks forward to their future development trend. This review provides a theoretical basis for studying the application of EFPs in the fields of biomedicine, cosmetics, health food, and promotes the development and utilization of EFPs.

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Metabolic degradation of lentinan in liver mediated by CYP450 enzymes and epoxide hydrolase

Zheng

Zhang

Liu

et al. 2021

Carbohydrate Polymers

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Effect of lentinan on membrane-bound protein expression in splenic lymphocytes under chronic low-dose radiation

Cited by 7 publications

References 22 publications

Clinical effects of lentinan combined with budesonide inhalation in treating acute exacerbation of chronic obstructive pulmonary disease under mechanical ventilation

Clinical effects of lentinan combined with budesonide inhalation in treating acute exacerbation of chronic obstructive pulmonary disease under mechanical ventilation

Research Progress on Biological Activities of Polysaccharides from Edible Fungus

Metabolic degradation of lentinan in liver mediated by CYP450 enzymes and epoxide hydrolase

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