Effect of Lentinus Edodes Mycelial Culture on Blood and Hepatic Steatosis of High-fed Diet Mice

Abstract

This study attempted to investigate the influence of a high-fat diet (HFD) on body weight, food efficiency ratio (FER), liver weight, blood composition and liver tissues. For this, it was divided into Normal, HFD/Control and HFD/MC-LE (360 mg/kg), and the experiment was performed over ten (10) weeks. Compared to HFD/Control, body weight decreased when HFD/MC-LE was administered. In addition, TG and AST blood concentration improved with HFD/MC-LE. In terms of celiac disease in liver tissues, hepatic sinusoids were closed due to the accumulation of adipose tissues. Furthermore, hepatocyte cords in a hepatic lobule and lipid accumulation in liver tissues were confirmed. In the liver tissues of HFD/MC-LE-administered mice, lipid accumulation decreased, and liver tissue damage was minor. The above results show that HFD/MC-LE is more effective than HFD/Control in reducing body weight, composing blood, preventing liver tissue damage and decreasing lipid accumulation in liver tissues confirming its possibility as a sub-ingredient for fatty liver treatment.