Effect of lesions in hippocampal subareas on rat shuttle behavior

Filho, Lineu S. Calderazzo; Cavalheiro, Ésper A.; Izquierdo, Iván

doi:10.1016/0031-9384(79)90286-5

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…We have demonstrated that bilateral lesions in the CA1 or DG subfields of the DH affected neither acquisition nor retention of TWAA memory. This is consistent with earlier studies, which demonstrated that the electrolytic lesions in the DG (Calderazzo Filho et al, 1979) and CA1 subfield of the DH (Calderazzo Filho et al, 1977; Hagan et al, 1988) did not affect performance of avoidance learning during the test trials. Another study has shown, however, that the application of colchicine, a neurotoxin that blocks mitosis and axoplasmic transport, into the DG enhances memory for TWAA learning (McLamb et al, 1988).…”

Section: Discussionsupporting

confidence: 92%

“…These excitotoxic lesions limited cell loss to a small part of the CA3. This result can be viewed as an elaboration of earlier electrolytic lesion studies, which have shown that lesioning the CA3 area of the hippocampus impaired retention of TWAA memory (Calderazzo Filho et al, 1977, 1979). Two other studies supported this data by demonstrating that the injection of neurotoxin AF64A impaired retention of TWAA memory by damaging the CA3 area of the DH (Bailey et al, 1986; Lermontova et al, 1998).…”

Section: Discussionsupporting

confidence: 77%

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Pontine‐wave generator activation‐dependent memory processing of avoidance learning involves the dorsal hippocampus in the rat

Datta¹,

Saha²,

Prutzman³

et al. 2005

J of Neuroscience Research

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The aim of this study was to test the hypothesis that the dorsal hippocampus plays a critical role in pontine-wave (P-wave) generator activation-dependent memory processing of two-way active avoidance (TWAA) learning. To achieve this objective, rats were given small bilateral lesions in the CA1, dentate gyrus (DG), or CA3 region of the dorsal hippocampus by microinjecting ibotenic acid. After recovery, lesioned and sham-lesioned rats were trained on a TWAA learning paradigm, allowed a 6-hr period of undisturbed sleep, and then were tested on the same TWAA paradigm. It was found that lesions in the CA3 region impaired retention of avoidance learning. Conversely, lesions in the CA1 and DG regions had no effect on TWAA learning retention. None of the groups showed any changes in the baseline sleep-wake cycle or in the acquisition of TWAA learning. All rats showed increased rapid eye movement (REM) sleep and increased REM sleep P-wave density during the subsequent 6-hr recording period. Impaired retention in the CA3 group occurred despite an increase in REM sleep and P-wave density, suggesting that during REM sleep, the P-wave generator interacts with the CA3 region of the dorsal hippocampus to aid in consolidation of TWAA learning. The results of the present study thus demonstrate that P-wave generator activation-dependent consolidation of memory requires an intact CA3 subfield of the dorsal hippocampus. The results also provide evidence that under mnemonic pressure, the dorsal hippocampus may not be involved directly in regulating the sleep-wake cycle. KeywordsREM sleep; two-way active avoidance; learning and memory; excitotoxic lesion; retention Many behavioral studies involving learning and memory in humans and animals provide considerable evidence to support the hypothesis that post-training sleep is critical for consolidation and integration of memories (reviewed in Hennevin et al

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 77%

Pontine‐wave generator activation‐dependent memory processing of avoidance learning involves the dorsal hippocampus in the rat

Datta¹,

Saha²,

Prutzman³

et al. 2005

J of Neuroscience Research

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“…Several studies have demonstrated that lesions in the CA3 subfield prevent retention, but not acquisition, of TWAA memory [10, 64–67]. There is increased activation of the immediate and early gene cFos in the CA3 region following both TWAA training and intracranial self-stimulation of the lateral hypothalamus, each of which improved memory retention during TWAA and together their actions had an additive on both CA3 cFos expression and TWAA performance [68].…”

Section: Discussionmentioning

confidence: 99%

Exercise reduces diet-induced cognitive decline and increases hippocampal brain-derived neurotrophic factor in CA3 neurons

Noble

Mavanji

Little

et al. 2014

Neurobiology of Learning and Memory

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Background Previous studies have shown that a western diet impairs, whereas physical exercise enhances hippocampus-dependent learning and memory. Both diet and exercise influence expression of hippocampal brain-derived neurotrophic factor (BDNF), which is associated with improved cognition. We hypothesized that exercise reverses diet-induced cognitive decline while increasing hippocampal BDNF. Methods To test the effects of exercise on hippocampal-dependent memory, we compared cognitive scores of Sprague-Dawley rats exercised by voluntary running wheel (RW) access or forced treadmill (TM) to sedentary (Sed) animals. Memory was tested by two-way active avoidance test (TWAA), in which animals are exposed to a brief shock in a specific chamber area. When an animal avoids, escapes or has reduced latency to do either, this is considered a measure of memory. In a second experiment, rats were fed either a high-fat diet or control diet for 16 weeks, then randomly assigned to running wheel access or sedentary condition, and TWAA memory was tested once a week for seven weeks of exercise intervention. Results Both groups of exercised animals had improved memory as indicated by reduced latency to avoid and escape shock, and increased avoid and escape episodes (p<0.05). Exposure to a high-fat diet resulted in poor performance during both the acquisition and retrieval phases of the memory test as compared to controls. Exercise reversed high-fat diet-induced memory impairment, and increased brain-derived neurotrophic factor (BDNF) in neurons of the hippocampal CA3 region. Conclusions These data suggest that exercise improves memory retrieval, particularly with respect to avoiding aversive stimuli, and may be beneficial in protecting against diet induced cognitive decline, likely via elevated BDNF in neurons of the CA3 region.

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Memory Formation: The Sequence of Biochemical Events in the Hippocampus and Its Connection to Activity in Other Brain Structures

Izquierdo

Medina

1997

Neurobiology of Learning and Memory

829

515

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Effect of lesions in hippocampal subareas on rat shuttle behavior

Cited by 6 publications

References 16 publications

Pontine‐wave generator activation‐dependent memory processing of avoidance learning involves the dorsal hippocampus in the rat

Pontine‐wave generator activation‐dependent memory processing of avoidance learning involves the dorsal hippocampus in the rat

Exercise reduces diet-induced cognitive decline and increases hippocampal brain-derived neurotrophic factor in CA3 neurons

Memory Formation: The Sequence of Biochemical Events in the Hippocampus and Its Connection to Activity in Other Brain Structures

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