Effect of letrozole for ovulation induction combined with intrauterine insemination on women with polycystic ovary syndrome

Doan, Hang Thi; Quan, Lam Hoang; Lam, Ngoc Mai

doi:10.1080/09513590.2020.1744556

Cited by 8 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, with controlled ovarian stimulation (COS), women with PCOS may overcome this obstacle and resume ovulation. [5,6] In department of reproductive medicine, intrauterine insemination (IUI) is a commonly-used method to enhance the likelihood of pregnancy before moving forward to complex therapy of in vitro fertilization and embryo transfer, for the reason that it is easy to operate, patient-friendly and economical. [7] COS, together with IUI, is now regarded as the first choice of infertile treatment for couples with PCOS.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of dual-trigger and human chorionic gonadotropin-only trigger among polycystic ovary syndrome couples who underwent controlled ovarian stimulation and intrauterine insemination: A retrospective cohort study

Wang

2023

Medicine

View full text Add to dashboard Cite

The dual-trigger regime, consisting of gonadotrophin releasing hormone agonist and human chorionic gonadotropin (HCG), has been shown to offer advantage over the HCG-only trigger regime. However, little is known about the influence of dual-trigger or HCG-only trigger regime on the reproductive outcome of polycystic ovary syndrome (PCOS) couples undergoing controlled ovarian stimulation (COS) and intrauterine insemination (IUI). A total of 404 cycles of COS and IUI treatments from couples with PCOS were enrolled, and divided, according to the regime of trigger, into dual-trigger group (n = 109, 0.1–0.2 mg gonadotrophin releasing hormone agonist plus 6000 IU HCG) and HCG-only group (n = 295, 10,000 IU HCG or 250 μg recombinant HCG). Baseline characteristics of the 2 groups were comparable (all P > .05). In dual-trigger group, live birth rate, clinical pregnancy rate and β -HCG positive rate were all higher as compared to the HCG-only group (20.18% vs 18.98%, 25.69% vs 23.39% and 28.44% vs 25.08% respectively), despite the differences failed to achieve statistical significances (all P > .05). Moreover, early miscarriage rate and multiple pregnancy rate of the dual-trigger group were lower than those of the HCG-only group (17.86% vs 18.84% and 3.57% vs 7.25% respectively), although no statistical significances were found (all P > .05). Additionally, logistic regression analysis revealed that age contributed significantly to the live birth of couples with PCOS ( P = .043, OR = 0.900). Dual-trigger regime for oocyte maturation seems to associate with beneficial improvements in reproductive outcomes of PCOS couples undergoing COS and IUI. Instead of HCG-only trigger, dual-trigger regime might be an alternative option in COS and IUI cycles for couples with PCOS.

show abstract

Section: Introductionmentioning

confidence: 99%

“…However, with controlled ovarian stimulation (COS), women with PCOS may overcome this obstacle and resume ovulation. [ 5 , 6 ]…”

Section: Introductionmentioning

confidence: 99%

Comparison of dual-trigger and human chorionic gonadotropin-only trigger among polycystic ovary syndrome couples who underwent controlled ovarian stimulation and intrauterine insemination: A retrospective cohort study

Wang

2023

Medicine

View full text Add to dashboard Cite

show abstract

“…Aromatase inhibitors (AIs) are a kind of medication that was first used to induce ovulation in 2001. Since about 2001, clinical investigations have concluded that the AI letrozole is at least as successful as the first-line therapy clomiphene citrate (CC) (Nguyen et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Letrozole and Clomiphene citrate versus Letrozole alone in ovulation induction for patients with Polycystic Ovarian Syndrome

Khodary

Ali

Amer

et al. 2022

SVU-International Journal of Medical Sciences

View full text Add to dashboard Cite

Background: Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrine and metabolic conditions in premenopausal women. Objectives: The goal of this study was to see the efficacy of Letrozole in conjunction with clomiphene citrate versus Letrozole alone in inducing ovulation in PCOS patients. Patients and methods: This was a randomized clinical trial (RCT) done on a total of 200 patients who came to South Valley University, Obstetrics and Gynecology clinics, after receiving the ethical committee permission and signed informed consent from all participants.Results: Regarding all treatment outcomes, there were no statistically substantial difference among the two groups as regards the following parameters: ovulation, mature follicle number, endometrial thickness, OHSS, single pregnancy, clinical pregnancy, multiple pregnancy and miscarriage, P>0.05. Conclusion: this research showed that in terms of infertility therapy in women with PCOS, the combination of letrozole and CC was linked to"Although there is absolute difference between the two groups in favor of the combined use of letrozole plus clomiphene citrate, this difference is not statistically significant". These new findings indicate that this combined therapy might be a low-risk, low-cost infertility treatments.

show abstract

“…Letrozole became a common drug treatment for inducing ovulation in anovulatory women for insemination cycles, with very good results [11]. Its use was well-established for breast cancer patients undergoing In Vitro Fertilization (IVF) cycles for fertility preservation and results were comparable to those of control patients [12].…”

Section: Introductionmentioning

confidence: 99%

Ovulatory-Based FET Cycles May Achieve Higher Pregnancy Rates in the General Population and among Anovulatory Women

Aslih

Dorzia

Atzmon

et al. 2021

JCM

View full text Add to dashboard Cite

This study evaluated which endometrial preparation protocol in frozen embryo transfer (FET) cycles provides the best results for polycystic ovarian syndrome (PCOS) patients and the general population. This retrospective study of 634 FET cycles was conducted 2016–2018. Cycles were divided into Group A: Artificial endometrial preparations for FET (aFET; n = 348), Group B: Ovulatory cycle (n = 286) to compare two methods of endometrial preparation for FET. Artificial endometrial preparation with exogenous estrogen and progesterone versus natural ovulation cycles, modified natural cycles using hCG for the final triggering and letrozole-induced ovulation with hCG. Anovulatory patients were analyzed separately. Anovulatory PCOS patients had significantly higher pregnancy rates with letrozole treatment compared with aFET cycles (44% vs. 22.5%; p = 0.044). For the entire cohort, ovulatory cycles and aFET were similar in terms of patient characteristics, demographics, infertility causes, treatment protocols and number of embryos transferred. Although the mean ESHRE score of the transferred embryos was higher in the aFET group, we found higher clinical pregnancy rate in the ovulatory cycle FET (41.3% vs. 27.3%, p < 0.0001). A better pregnancy rate was found after ovulatory cycle FET. In the ovulatory cycles, the outcome of letrozole-induced and non-induced cycles were comparable. PCOS patients, as well as the general population, may benefit from ovulation induced FET cycles, with significantly better outcomes in FET in ovulatory cycles.

show abstract

Effect of letrozole for ovulation induction combined with intrauterine insemination on women with polycystic ovary syndrome

Cited by 8 publications

References 16 publications

Comparison of dual-trigger and human chorionic gonadotropin-only trigger among polycystic ovary syndrome couples who underwent controlled ovarian stimulation and intrauterine insemination: A retrospective cohort study

Comparison of dual-trigger and human chorionic gonadotropin-only trigger among polycystic ovary syndrome couples who underwent controlled ovarian stimulation and intrauterine insemination: A retrospective cohort study

Letrozole and Clomiphene citrate versus Letrozole alone in ovulation induction for patients with Polycystic Ovarian Syndrome

Ovulatory-Based FET Cycles May Achieve Higher Pregnancy Rates in the General Population and among Anovulatory Women

Contact Info

Product

Resources

About