Effect of letrozole for prevention of ovarian hyperstimulation syndrome (OHSS) in a rat model

Akman, Levent; Akdoğan, Ayşin; Erbaş, Oytun; Aktuğ, H; Şahin, Gülnaz; Tavmergen, Erol

doi:10.1016/j.fertnstert.2013.07.1086

Cited by 2 publications

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“…Letrozole is effective in reducing body weight, ovarian weight, vasoactive peptides, and vascular endothelial growth factor (VEGF) expression in OHSS and maybe a new treatment modality for preventing and controlling OHSS. 50 In a study, a total of 88 patients were randomly divided into a control group not receiving letrozole, and groups treated with 2.5, 5, or 7.5 mg of letrozole post oocyte retrieval. From the fifth day after human chorionic gonadotropin (HCG) trigger, the level of VEGF was found to increase in the control group, but decrease in the letrozole groups in a dose-dependent manner.…”

Section: Ohss Prevention: a Newer Angle For The Use Of Letrozolementioning

confidence: 99%

Current Knowledge on the Use of Letrozole in Ovarian Stimulation

Mangal¹

2020

International Journal of Infertility &Amp; Fetal Medicine

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Androgens are converted to estrogens by the enzyme called aromatase. This process called aromatization is inhibited by a group of drugs called aromatase inhibitors (AIs). Letrozole is a nonsteroidal inhibitor that reversibly binds aromatase. Decrease in circulating estradiol level leads to release of negative feedback at hypothalamus pituitary level, thereby increasing follicle stimulating hormone (FSH) secretion resulting in stimulation of growth of ovarian follicles. Letrozole is well tolerated and is used in different protocols of ovarian stimulation. The extended spectrum of uses includes addition with gonadotrophins in poor responders, ovarian hyperstimulation syndrome (OHSS) prevention, fertility preservation in cancer patients. Due to its wide range of use, easy availability, affordability and good tolerability, Letrozole has emerged as a first line drug for ovulation induction.

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Section: Ohss Prevention: a Newer Angle For The Use Of Letrozolementioning

confidence: 99%