Effect of leukocytes included in platelet concentrates on cell behaviour

Puidokas, Tomas; Kubilius, Mantas; Stumbras, Artūras; Juodžbalys, Gintaras

doi:10.1080/09537104.2019.1646900

Cited by 9 publications

(6 citation statements)

References 55 publications

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“…Some reports propose eliminating leukocytes, 35 while others consider the anti‐infectious, growth factor secreting, and anti‐inflammatory benefits of leukocytes 36,37 . Puidokas and colleagues 38 conducted a systematic review which found that in the presence of WBCs, platelet concentrates promote cell migration, proliferation, and differentiation less effectively and are responsible for a potentially prolonged inflammation phase due to cytokine release. In our study, CGF promoted the healing of soft tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Some reports propose eliminating leukocytes, 35 while others consider the antiinfectious, growth factor secreting, and anti-inflammatory benefits of leukocytes. 36,37 Puidokas and colleagues 38 thus adversely impact horizontal bone remodeling and keratinized tissue width. 42,43 It is thus important to minimize the invasiveness of all surgical approaches wherever possible.…”

Section: Discussionmentioning

confidence: 99%

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The impact of autologous concentrated growth factors on the alveolar ridge preservation after posterior tooth extraction: A prospective, randomized controlled clinical trial

Lin

Sun

et al. 2021

Clin Implant Dent Rel Res

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Background Alveolar ridge preservation can effectively decrease alveolar ridge resorption following tooth extraction, but it can be limited by reducing new bone formation and residual bone graft material. Efforts to develop more efficacious approaches are thus an area of active research. Purpose To assess the impact of autologous concentrated growth factors (CGF) on alveolar ridge absorption and osteogenesis following posterior tooth extraction. Materials and methods Fifty patients were randomly assigned to have extraction sockets treated with CGF or no treatment. At 10 days, 1 month, and 3 months postextraction, soft tissue color and texture were examined and evaluated with healing score. Cone‐beam computed tomography (CBCT) scans were performed before and 3 months after extraction, while radiographic analyses were used to assess vertical and horizontal bone changes. Bone samples were collected from the extraction sockets during implant placement, and micro‐computed tomography (micro‐CT) scans and histological analysis were performed to evaluate new bone formation. t‐Test or Mann–Whitney U test was used to compare data and the level of statistical significance was set at 0.05 for all analyses. Results Forty‐six patients completed the trial. Sockets in the experimental group exhibited significantly better healing score on Day 10 postextraction relative to the control group, whereas comparable healing was observed in both groups at 1 and 3 months postextraction. Experimental group exhibited reduced vertical bone changes relative to the control (p < 0.05). Significant reductions were observed in ridge width changes at 1 and 2 mm apical to the crest (p < 0.05), although differences at 3 and 5 mm apical to the crest were not significant. Significant differences of bone mineral density (BMD) and microarchitecture of trabecular bone were observed via micro‐CT analyses, and the experimental group had better results. Conclusion CGF application following posterior tooth extraction may reduce vertical and horizontal bone resorption and promote new bone formation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The impact of autologous concentrated growth factors on the alveolar ridge preservation after posterior tooth extraction: A prospective, randomized controlled clinical trial

Lin

Sun

et al. 2021

Clin Implant Dent Rel Res

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“…In an inflammatory medium, leukocytes are able to produce pro‐inflammatory cytokines, enzymes, and oxygen reactive species that may damage tissue healing and increase inflammation 31 . A recently performed literature review 32 which analyzed the effect of leucocytes included in platelet concentrates concluded that leucocytes are responsible for prolonged inflammation phase and less effective cell migration, proliferation and differentiation. It has been preconized that using PRGF not only stimulates bone and soft tissue healing but it also initiates cross‐linked fibrin network formation, provides a barrier against pathogens, serves as a matrix for tissue regeneration, and acts as a reservoir of growth factors for the healing process 33 .…”

Section: Introductionmentioning

confidence: 99%

Three‐dimensional analysis of dimensional changes after alveolar ridge preservation with bone substitutes or plasma rich in growth factors: Randomized and controlled clinical trial

Stumbras

Galindo‐Moreno

Janužis

et al. 2020

Clin Implant Dent Rel Res

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Objectives To evaluate alveolar ridge dimensional changes of different alveolar ridge preservation techniques after 3 months of tooth extraction and to compare the efficacy of autologous plasma rich in growth factor (PRGF) to the bone substitutes in alveolar ridge preservation and sites left to heal spontaneously. Materials and Methods Forty patients requiring tooth extraction in the anterior maxilla were randomly allocated to the four following treatment modalities: spontaneous healing (control), natural bovine bone mineral covered with resorbable native collagen membrane (BBM/CM), freeze‐dried bone allograft covered with resorbable native collagen membrane (FDBA/CM) and PRGF alone. Cone beam computed tomography (CBCT) scans were taken after surgery and 3 months later. The measurements of height and width (at 1, 3, and 5 mm below the crest) were performed after superimposing the 2 consecutive CBCT scans. Results The greatest horizontal alveolar bone resorption at 1 mm below bone crest was observed in the control group (−1.61 ± 1.76 mm, P = .037), whereas the least reduction in width was found in the BBM/CM group (−0.68 ± 0.67 mm, P = .037). The most pronounced alveolar height reduction was observed in the control group (−0.86 ± 0.43 mm), whereas alveolar ridge preservation with BBMC/CM (−0.26 ± 0.91 mm) and PRGF (−0.54 ± 0.86 mm) successfully reduced the alveolar height reduction as compared to the control group. Conclusions Alveolar ridge preservation technique in the esthetic zone using BBM/CM or using PRGF is beneficial to reduce horizontal and vertical bone changes.

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“…Leukocytes and platelets are also involved in inflammation. Leukocyte and platelet functions are similar when considering growth factor releasing ( Puidokas et al, 2019 ); therefore, WPR is also a good indicator of the degree of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Early platelet level reduction as a prognostic factor in intensive care unit patients with severe aspiration pneumonia

Wang

Shao

et al. 2023

Front. Physiol.

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Introduction: This study investigates risk factors underlying the prognosis of severe aspiration pneumonia (SAP) in intensive care unit (ICU) patients and attempts to provide early prognosis reference for clinical tasks.Methods: Patients diagnosed with SAP and admitted to the ICU of Jinshan Hospital, Fudan University, Shanghai, China, between January 2021 and December 2021 were recruited in this retrospective cohort study. Clinical data on a patient’s general condition, underlying diseases, laboratory indicators, and 90-day outcomes (survival or death) were recorded.Results: Multivariate logistic regression analysis showed that a low platelet count was an independent risk factor affecting the prognosis of death (OR = 6.68, 95% CI:1.10–40.78, β = 1.90, P = 0.040). Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive value of variables; cut-off values were calculated and the area under the curve was 0.7782 [(95% CI:0.686–0.871), p < 0.001] for the prediction of death at 90 days in all patients. The Kaplan-Meier curve used for survival analysis showed that, compared with the normal platelet group, the overall survival rate of patients with low platelet levels was significantly lower, and the difference was statistically significant [HR = 2.11, (95% CI:1.47–3.03), p = 0.0001, z = 4.05, X2 = 14.89]. Cox regression analysis, used to further verify the influence of prognostic risk factors, showed that a concurrent low platelet count was the most important independent risk factor affecting the prognosis of SAP (HR = 2.12 [95% CI:1.12–3.99], X2 = 50.95, p = 0.021).Conclusion: These findings demonstrate an association between SAP mortality and platelet levels on admission. Thus, platelet level at admission may be used as a readily available marker for assessing the prognosis of patients with SAP.

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Effect of leukocytes included in platelet concentrates on cell behaviour

Cited by 9 publications

References 55 publications

The impact of autologous concentrated growth factors on the alveolar ridge preservation after posterior tooth extraction: A prospective, randomized controlled clinical trial

The impact of autologous concentrated growth factors on the alveolar ridge preservation after posterior tooth extraction: A prospective, randomized controlled clinical trial

Three‐dimensional analysis of dimensional changes after alveolar ridge preservation with bone substitutes or plasma rich in growth factors: Randomized and controlled clinical trial

Early platelet level reduction as a prognostic factor in intensive care unit patients with severe aspiration pneumonia

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