Effect of Levodopa on Healthy Volunteers' Facial Emotion Perception

Delaveau, Pauline; Salgado‐Pineda, Pilar; Wicker, Bruno; Micallef-Roll, Joëlle; Blin, Olivier

doi:10.1097/01.wnf.0000186651.96351.2e

Cited by 40 publications

(25 citation statements)

References 38 publications

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“…For example, administration of D-amphetamine boosts amygdalar reactivity to fearful and angry facial expressions, which fits nicely with the finding that dampened amygdalar reactivity in hypodopaminergic Parkinson patients can be restored back to normal levels by administering L-DOPA Tessitore et al, 2002;Kawamura and Kowayakaba, 2009). In sharp contrast, however, administration of L-DOPA and D-amphetamine has also been found to dampen aversive emotional reactions such as amygdalar reactivity to fearful faces and fear-potentiated startle to unpleasant stimuli (Delaveau et al, 2005(Delaveau et al, , 2007(Delaveau et al, , 2009Corr and Kumari, 2013). This apparent inconsistency may be clarified when considering that increasing DA activity through pharmacological interventions only has anxiogenic effects in high-anxiety individuals, whereas in low-anxiety subjects, the same DA increase has an anxiolytic effect (Mizuki et al, 1997).…”

Section: Serotonin X Dopamine Interactions: Explaining Interhemisphermentioning

confidence: 81%

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

Yildirim

Derksen

2015

Psychiatry Research

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Section: Serotonin X Dopamine Interactions: Explaining Interhemisphermentioning

confidence: 81%

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

Yildirim

Derksen

2015

Psychiatry Research

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“…The amygdala is partially controlled by the brain's dopamine system (Delaveau et al 2005), as an essential part of the brain-reward circuitry-the same system that responds to alcohol and produces feelings of pleasure when good things happen (Koob 2003). In a recent study using fMRI in our laboratory ), we observed clear evidence of differences between abstinent long-term alcoholics and nonalcoholic controls in amygdala activation to emotional materials.…”

Section: Neural Systems Affected and Concomitant Neurobehavioral Defimentioning

confidence: 89%

Alcohol: Effects on Neurobehavioral Functions and the Brain

2007

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Alcoholism results from an interplay between genetic and environmental factors, and is linked to brain defects and associated cognitive, emotional, and behavioral impairments. A confluence of findings from neuroimaging, physiological, neuropathological, and neuropsychological studies of alcoholics indicate that the frontal lobes, limbic system, and cerebellum are particularly vulnerable to damage and dysfunction. An integrative approach employing a variety of neuroscientific technologies is essential for recognizing the interconnectivity of the different functional systems affected by alcoholism. In that way, relevant experimental techniques can be applied to assist in determining the degree to which abstinence and treatment contribute to the reversal of atrophy and dysfunction.

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“…We hypothesized that nondemented, nondepressed patients would show intact performance during an emotional processing task but that levodopa medication would overdose limbic regions and so disrupt normal amygdala functioning, as it does in healthy subjects. 2,3 …”

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confidence: 98%

“…1Y3 In 2 previous studies, we showed that levodopa administration in healthy subjects (temporary DA overdose status) led to a decreased amygdalar activation during emotional faces processing. 2,3 In Parkinson disease (PD), DA denervation progresses from dorsal regions (first the putamen then the caudate) to the ventral striatum. 4,5 Therefore, PD patients may present different neurocognitive changes as a function of the degree of DA depletion in these different regions.…”

mentioning

confidence: 99%

Dopaminergic Modulation of Amygdala Activity During Emotion Recognition in Patients With Parkinson Disease

Delaveau¹,

Salgado‐Pineda²,

Witjas³

et al. 2009

Journal of Clinical Psychopharmacology

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Variable findings have been reported for emotional processing in patients with Parkinson disease (PD). These contradictions could be due to differences in the progression of dopamine (DA) depletion. Levodopa treatment could have either beneficial or detrimental effects on brain functions modulated by DA according to disease progression. In healthy subjects, levodopa administration leads to a decreased amygdala activation in response to emotional tasks. Because it is known that there is a link between DA loss in mesolimbic system and depression, we hypothesized that PD patients without depression would have spared limbic DA projections. Consequently, levodopa medication could overdose limbic regions relative to severe dorsal striatal denervation. To evaluate the effect of levodopa on amygdala activation, we conducted a functional magnetic resonance imaging study in nondemented, nondepressed PD patients compared with healthy volunteers. Patients with PD and healthy subjects received either levodopa or placebo in 2 functional magnetic resonance imaging sessions. Amygdala activation was evaluated during a facial emotion recognition task. A similar right-amygdala activity was seen in both healthy subjects and PD patients in the placebo session. After levodopa administration, activity was reduced in both groups. In the patients, the levodopa dose used significantly improved motor dysfunction. Nondemented, nondepressed PD patients thus seem to have relatively preserved DA mesolimbic projections, and consequently, the same dose of levodopa needed to correct the lack of DA in the severely depleted putamen (motor part of striatum) would incidentally overdose the mesolimbic projections toward the amygdala.

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Effect of Levodopa on Healthy Volunteers' Facial Emotion Perception

Cited by 40 publications

References 38 publications

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

Alcohol: Effects on Neurobehavioral Functions and the Brain

Dopaminergic Modulation of Amygdala Activity During Emotion Recognition in Patients With Parkinson Disease

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