1977
DOI: 10.1007/bf00607426
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Effect of lidocaine on the absorption, disposition and tolerance of intramuscularly administered cefoxitin

Abstract: The use of lidocaine HCL solution at concentrations of 0.5 and 1.0% to reconstitute sodium cefoxitin relieves the pain associated with intramuscular injections of the antibiotic. Cefoxitin absorption by the intramuscular route is initially rapid and is virtually complete. Peak serum concentrations, corresponding to about one-half those of a comparable intravenous infusion, are achieved in 30 min. Continuing absorption tends to maintain higher serum concentrations for longer times. Renal clearance and serum hal… Show more

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Cited by 18 publications
(3 citation statements)
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“…administration of a 0.5-g dose in the previous study (5; Table 6). This indicates that The effects of lidocaine on the pharmacokinetic and tolerance parameters of ceftriaxone are consistent with those reported for cefoxitin by Sonneville et al (10) and for cefamandole by Foster et al (2). In both of these studies, lidocaine (0.5 to 1%) reduced the pain associated with i.m.…”
Section: Resultssupporting
confidence: 89%
“…administration of a 0.5-g dose in the previous study (5; Table 6). This indicates that The effects of lidocaine on the pharmacokinetic and tolerance parameters of ceftriaxone are consistent with those reported for cefoxitin by Sonneville et al (10) and for cefamandole by Foster et al (2). In both of these studies, lidocaine (0.5 to 1%) reduced the pain associated with i.m.…”
Section: Resultssupporting
confidence: 89%
“…The renal clearance of cefoxitin after intravenous and intramuscular administration is similar. Use of a 0.5% or 1 % lidocaine solution as diluent for the intramuscular dosage has no effect on the absorption or disposition of cefoxitin (SONNEVILLE et al 1977;BRUMFITT et al 1974;WISE et al 1979a.…”
Section: Cefoxitinmentioning
confidence: 98%
“…This pain may be due to direct chemical irritation or the volume of solution administered (6). Pain on injection can be partially overcome by the use of a local anesthetic as a diluent (9,15).…”
mentioning
confidence: 99%