Effect of lindane on human lymphocyte responses to phytohemagglutinin

Alterations in T-lymphocyte sub-set profiles and cytokine secretion by PBMC of systemic lupus erythematosus patients uponin vitroexposure to organochlorine pesticides

“…These values for the OCP were purposely selected to be well below the previously reported values that would induce overt cytotoxicity to cultured human PBMC/lymphocytes. Specifically, with regard to β-HCH, Huber et al (1990) reported an EC 50 [cytotoxicity] of 100 µM and Roux et al (1979) showed that even a dose of 200 µM β-HCH (for 72 h) had no effect on the viability of cultured human lymphocytes. For DDT, a study by Yanez et al (2004) using PBMC cultured with 40-100 µg DDT/ml (113-282 µM) for 72 h indicated that with the highest dose there was only a 3% drop in viability of the cells from that of untreated controls.…”

Immunotoxicity of Pesticides

“…Administration of 150 ppm lindane per day orally for 1 month to mice did not alter the levels of IgA, IgG 1, IgG2a, and IgM in the serum or the ability to generate a humoral immune response to SRBC (Andre et al, 1983). In vitro exposure of human PBMC to 0.1-0.3 mM lindane inhibited the mitogenic response to a T-cell mitogen (Roux et al, 1979). In the rabbit, administration of 3 mg/kg/day or more lindane for 5 weeks decreased the humoral immune response to bacterial antigen (D6si et al, 1978;Kaliser, 1968).…”

Control of cililary beat by calcium: the effects of lindane, a potent insectiside

“…Most of the known biological effects of lindane seem to imply a membrane effect and perturbations of calcium fluxes are frequently involved after treatment of different kinds of cells by the pesticides: oocytes [24], macrophages [19], and mouse neuromuscular junctions [7]. Most of the known biological effects of lindane seem to imply a membrane effect and perturbations of calcium fluxes are frequently involved after treatment of different kinds of cells by the pesticides: oocytes [24], macrophages [19], and mouse neuromuscular junctions [7].…”

“…Due to the insecticide properties of lindane, many studies have been conducted to determine its action at the cellular and molecular levels on target cells. Most of the known biological effects of lindane seem to imply a membrane effect and perturbations of calcium fluxes are frequently involved after treatment of different kinds of cells by the pesticides: oocytes [24], macrophages [19], and mouse neuromuscular junctions [7]. It is well known that lindane can effect Ca + + and Mg + + ATPases [6].…”