Effect of linoleic acid intake on growth of infants with cystic fibrosis

Egmond, A. W. A. Van; Kosorok, Michael R.; Koscik, Rebecca E.; Laxova, Anita; Farrell, Philip M.

doi:10.1093/ajcn/63.5.746

Cited by 83 publications

(43 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The experimental design and purpose of the Wisconsin CF Neonatal Screening Project have been described in detail elsewhere. 10,11 In summary, a randomized clinical trial is being conducted to assess the potential benefits and risks of newborn screening for CF using measurement of either immunoreactive trypsinogen (IRT) from April 4, 1985 to June 30, 1991 or the combination of IRT assays and DNA analyses for the F 508 mutation from July 1, 1991 to June 30, 1994. 12,13 Health care providers at the two centers developed a screening plan and a standardized evaluation and treatment protocol in 1984 and have met regularly during the study to monitor implementation of protocols and ongoing results.…”

Section: Methods Experimental Design and Methodsmentioning

confidence: 99%

Acquisition ofPseudomonas aeruginosain Children With Cystic Fibrosis

et al. 1997

View full text Add to dashboard Cite

ABSTRACT. Objective. This study was pursued as an extension of a randomized clinical investigation of neonatal screening for cystic fibrosis (CF). The project included assessment of respiratory secretion cultures for pathogens associated with CF. The objective was to determine whether patients diagnosed through neonatal screening and treated in early infancy were more likely to become colonized with Pseudomonas aeruginosa compared with those identified by standard diagnostic methods.Methodology. The design involved prospective cultures of respiratory secretions obtained generally by oropharyngeal swabs at least every 6 months and more often if clinically indicated. Patients were managed with a standardized evaluation and treatment protocol at the two Wisconsin certified CF centers; however, there were community and environmental variations associated with the follow-up period as described below.Results. Overall, there were no differences in acquisition of respiratory pathogens between the screened and the control (standard diagnosis) groups. Evaluation of the data between and within the two centers, however, revealed significant differences with earlier acquisition of P aeruginosa in the center with the following distinguishing characteristics: urban location; following patients with the standard US approach in which newly diagnosed, young children were interspersed with older CF patients; and where there were more opportunities for social interactions with other CF patients. The differences were confined to the screened group followed in the urban center in which the median pseudomonas-free survival period was 52 weeks contrasted with 289 weeks in the other center. In addition, assessment of data for the entire CF populations followed at the two centers revealed that the urban center showed a significantly higher prevalence of P aeruginosa colonization in patients between the ages of 3 and 9 years.Conclusions. These results present questions and generate hypotheses on risk factors for acquisition of P aeruginosa in CF and suggest that clinic exposures and/or social interactions may predispose such patients to pseudomonas infections. Pediatrics 1997;100(5). URL: http://www.pediatrics.org/cgi/content/full/100/5/e2; cystic fibrosis, Pseudomonas aeruoginosa, transmission, epidemiology, pulmonary disease.

show abstract

Section: Methods Experimental Design and Methodsmentioning

confidence: 99%

Acquisition ofPseudomonas aeruginosain Children With Cystic Fibrosis

et al. 1997

View full text Add to dashboard Cite

show abstract

“…Essential fatty acid deficiency from disturbances in biosynthetic pathways of arachidonic and docosahexenoic acid synthesis results from as yet undetermined causes and results in sequelae of uncertain significance [60]. Although correction of serum levels of EFA's is possible and has been shown to improve growth in limited studies [61,62], it should be approached with caution until these mechanisms and sequelae are better understood [60]. Table 3 lists opportunities to prevent malnutrition and improve nutrition and growth.…”

Section: Nutritional Benefits Of Cf Nbs and Treatment Of Gastrointestmentioning

confidence: 99%

Newborn Screening for Cystic Fibrosis

Sharp

Rock

2008

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

Newborn screening (NBS) for cystic fibrosis (CF) has evolved considerably from its beginnings. We review the early history of NBS in the USA and the evolution of CF NBS from its conception in observational studies, to the development of mass-screening methodology in the 1970s, and to its early applications in the USA and other countries. We review the development of current CF NBS algorithms, particularly the development of those used in the Wisconsin randomized controlled trial, and discuss the comparative utility of different algorithms. We also discuss the identified nutritional and respiratory benefits of CF NBS, discuss treatment strategies for newborns identified with CF, and also discuss opportunities for slowing the progression of this disease.

show abstract

“…Essential fatty acid administration in CF was shown to improve nutritional status [29]and growth [30]. n-3 Fatty acids are of particular interest for their anti-inflammatory properties in CF as in many diseases with chronic inflammation.…”

Section: Lipids and Growthmentioning

confidence: 99%

Nutrition and Growth in Cystic Fibrosis

2002

View full text Add to dashboard Cite

Malnutrition is a common complication of chronic diseases in children and may lead to growth impairment (stunting). Malnutrition in cystic fibrosis (CF) results from increased energy expenditure, decreased energy intakes, malabsorption of ingested nutrients because of pancreatic insufficiency and chronic inflammation. Malnutrition and high levels of inflammatory cytokines affect IGF-1 production through interrelated mechanisms. Nutritional support was shown to improve both nutritional status and outcome in CF. However, some nutrients have a direct effect on the disease. n-3 fatty acids supplementation is able to correct lipid abnormalities resulting from a primary mechanism. Moreover, n-3 fatty acids have a direct effect on the inflammatory response, decreasing eicosanoid synthesis and modulating nuclear transcriptional factors nuclear factor ĸB and peroxisome proliferator-activated receptors γ. Nutritional support may be considered part of the care of the CF patient together with antibiotics, pancreatic enzymes and physiotherapy, influencing significantly the evolution of the disease.

show abstract

Effect of linoleic acid intake on growth of infants with cystic fibrosis

Cited by 83 publications

References 31 publications

Acquisition ofPseudomonas aeruginosain Children With Cystic Fibrosis

Acquisition ofPseudomonas aeruginosain Children With Cystic Fibrosis

Newborn Screening for Cystic Fibrosis

Nutrition and Growth in Cystic Fibrosis

Contact Info

Product

Resources

About