Effect of linseed oil and macadamia oil on metabolic changes induced by high‐fat diet in mice

Barrena, Helenton C.; Schiavon, Fabiana P. M.; Cararra, Marcia A.; Marques, Any de Castro Ruiz; Schamber, Christiano Rodrigues; Curi, Rui; Bazotte, Roberto Barbosa

doi:10.1002/cbf.3018

Cited by 7 publications

(7 citation statements)

References 42 publications

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“…They were then randomly divided into groups that received HCD (73.8% carbohydrates, 14.2% proteins, and 4% lipids) or HFD (36.5% carbohydrates, 20.3% proteins, and 35.2% lipids) for 1 or 2 months ( Figure 1). Specific nutrients and FA composition of the diets (HCD or HFD) are described in our previous publications (14,16). All mice had free access to food and water.…”

Section: Animals and Experimental Designmentioning

confidence: 99%

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A high-carbohydrate diet induces greater inflammation than a high-fat diet in mouse skeletal muscle

Antunes

Godoy

Almeida-Souza

et al. 2020

Braz J Med Biol Res

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We previously reported that both the high-carbohydrate diet (HCD) and high-fat diet (HFD) given for two months promote lipid deposition and inflammation in the liver and brain of mice. The results obtained indicate a tissue-specific response to both diets. Herein, we compared the effects of HCD and HFD on fatty acid (FA) composition and inflammation in the gastrocnemius muscle. Male Swiss mice were fed with HCD or HFD for 1 or 2 months. Saturated FA (SFA), monounsaturated FA (MUFA), n-3 polyunsaturated FA (n-3 PUFA), and n-6 PUFA were quantified. The activities of stearoyl-CoA desaturase 1 (SCD-1), D-6 desaturase (D6D), elongase 6, and de novo lipogenesis (DNL) were estimated. As for indicators of the inflammatory tissue state, we measured myeloperoxidase (MPO) activity and gene expression of F4/80, tumor necrosis factor-a (TNF-a), interleukin (IL)-4, IL-6, and IL-10. The HCD led to a lower deposition of SFA, MUFA, n-3 PUFA, and n-6 PUFA compared to HFD. However, the HCD increased arachidonic acid levels, SFA/n-3 PUFA ratio, DNL, SCD-1, D6D, and MPO activities, and expression of IL-6, contrasting with the general idea that increased lipid deposition is associated with more intense inflammation. The HCD was more potent to induce skeletal muscle inflammation than the HFD, regardless of the lower lipid accumulation.

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Section: Animals and Experimental Designmentioning

confidence: 99%

“…Overnight-fasted mice (from 17:00 to 08:00), as described in our previous studies (9,(14)(15)(16)(17), were then euthanized by decapitation. Gastrocnemius muscle from both legs was removed, frozen in liquid nitrogen, and stored at -80°C until analysis.…”

Section: Animals and Experimental Designmentioning

confidence: 99%

A high-carbohydrate diet induces greater inflammation than a high-fat diet in mouse skeletal muscle

Antunes

Godoy

Almeida-Souza

et al. 2020

Braz J Med Biol Res

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“…6 Instead, insulinstimulated signal transduction pathways for peripheral glucose uptake and for hepatic glucose production are reduced, including insulin receptors and downstream mediators. [7][8][9] Hyperglycemia is then driven by excessive hepatic glucose production 10,11 and reduced uptake of glucose by peripheral tissues. 12 To counteract resultant glycemic elevations, b cells of the pancreas boost insulin production, further contributing to hyperinsulinemia.…”

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confidence: 99%

Insulin resistance in the liver: Deficiency or excess of insulin?

2014

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In insulin-resistant states (obesity, pre-diabetes, and type 2 diabetes), hepatic production of glucose and lipid synthesis are heightened in concert, implying that insulin deficiency and insulin excess coexists in this setting. The fact that insulin may be inadequate or excessive at any one point in differing organs and tissues has many biologic ramifications. In this context the concept of metabolic compartmentalization in the liver is offered herein as one perspective of this paradox. In particular, we focus on the hypothesis that insulin resistance accentuates differences in periportal and perivenous hepatocytes, namely periportal glucose production and perivenous lipid synthesis. Subsequently, excessive production of glucose and accumulation of lipids could be expected in the livers of patients with obesity and insulin resistance. Overall, in this review, we provide our integrative perspective regarding how excessive production of glucose in periportal hepatocytes and accumulation of lipids in perivenous hepatocytes interact in insulin resistant states.

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“…Experiments in rat models of metabolic syndrome, diet supplementation with macadamia oil resulted in a decrease in fasting plasma insulin and a significant reduction in visceral fat [ 50 ]. However, another study utilizing mice fed a hyperlipidemic diet plus the macadamia oil supplement did not detect any reduction in the high glucose levels of these animals [ 51 ].…”

Section: Obesity and Diabetesmentioning

confidence: 99%

Roles of Palmitoleic Acid and Its Positional Isomers, Hypogeic and Sapienic Acids, in Inflammation, Metabolic Diseases and Cancer

Bermúdez

Pereira

Fraile

et al. 2022

Cells

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In the last few years, the monounsaturated hexadecenoic fatty acids are being increasingly considered as biomarkers of health with key functions in physiology and pathophysiology. Palmitoleic acid (16:1n-7) and sapienic acid (16:1n-10) are synthesized from palmitic acid by the action of stearoyl-CoA desaturase-1 and fatty acid desaturase 2, respectively. A third positional isomer, hypogeic acid (16:1n-9) is produced from the partial β-oxidation of oleic acid. In this review, we discuss the current knowledge of the effects of palmitoleic acid and, where available, sapienic acid and hypogeic acid, on metabolic diseases such as diabetes, cardiovascular disease, and nonalcoholic fatty liver disease, and cancer. The results have shown diverse effects among studies in cell lines, animal models and humans. Palmitoleic acid was described as a lipokine able to regulate different metabolic processes such as an increase in insulin sensitivity in muscle, β cell proliferation, prevention of endoplasmic reticulum stress and lipogenic activity in white adipocytes. Numerous beneficial effects have been attributed to palmitoleic acid, both in mouse models and in cell lines. However, its role in humans is not fully understood, and is sometimes controversial. Regarding sapienic acid and hypogeic acid, studies on their biological effects are still scarce, but accumulating evidence suggests that they also play important roles in metabolic regulation. The multiplicity of effects reported for palmitoleic acid and the compartmentalized manner in which they often occur, may suggest the overlapping actions of multiple isomers being present at the same or neighboring locations.

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Effect of linseed oil and macadamia oil on metabolic changes induced by high‐fat diet in mice

Cited by 7 publications

References 42 publications

A high-carbohydrate diet induces greater inflammation than a high-fat diet in mouse skeletal muscle

A high-carbohydrate diet induces greater inflammation than a high-fat diet in mouse skeletal muscle

Insulin resistance in the liver: Deficiency or excess of insulin?

Roles of Palmitoleic Acid and Its Positional Isomers, Hypogeic and Sapienic Acids, in Inflammation, Metabolic Diseases and Cancer

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