Effect of Lipid‐Modifying Therapy on Long‐Term Mortality After Abdominal Aortic Aneurysm Repair: A Systemic Review and Meta‐Analysis

Zhang, Wenwen; Liu, Zhao; Liu, Changjian

doi:10.1007/s00268-014-2858-7

Cited by 19 publications

(9 citation statements)

References 48 publications

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“…angiotensin converting enzyme inhibitors, beta blocking agents), lipid modifying therapy (i.e. statins), and antiplatelets 485,183,[486][487][488] although evidence about single drugs may be conflicting 489,490 . Applicable guidelines should be consulted for specific guidance on which atherosclerotic manifestation warrants which secondary prophylaxis.…”

Section: Medical Management After Aaa Repairmentioning

confidence: 99%

Editor's Choice – European Society for Vascular Surgery (ESVS) 2019 Clinical Practice Guidelines on the Management of Abdominal Aorto-iliac Artery Aneurysms

Wanhainen¹,

Verzini²,

Herzeele³

et al. 2019

European Journal of Vascular and Endovascular Surgery

1,962

1,522

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Section: Medical Management After Aaa Repairmentioning

confidence: 99%

Editor's Choice – European Society for Vascular Surgery (ESVS) 2019 Clinical Practice Guidelines on the Management of Abdominal Aorto-iliac Artery Aneurysms

Wanhainen¹,

Verzini²,

Herzeele³

et al. 2019

European Journal of Vascular and Endovascular Surgery

1,962

1,522

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“…Similarly, Kaye et al [35] found that if the levels of HDL are insufficient, cholesterol and lipids in arterial walls trigger an exacerbated inflammatory response. Meta-analysis reported that low serum lipids may reduce patient mortality after abdominal aortic aneurysm repair [13]. Overall, increased TG/HDLc ratio in type B AAD is associated with aortic stiffness, inflammatory factors, and oxidative stress.…”

Section: Discussionmentioning

confidence: 98%

“…To date, dyslipidemia is a well-documented risk factor for stroke [8,9], metabolic syndrome [10], and cardiovascular disease [11,12]. Moreover, results from a meta-analysis suggested that lipid-modifying therapy is a protective factor on mortality after abdominal aortic aneurysm repair [13]. A cross-sectional study implicated dyslipidemia aortic stiffness [14], with international guidelines stating that lipid profiles should be managed [15].…”

Section: Introductionmentioning

confidence: 99%

Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B Aortic Dissection

Zhou

Yang

et al. 2020

BioMed Research International

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Background. Triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio varies with vascular and other metabolic diseases. However, its role in acute type B aortic dissection is not well understood. In the current study, we evaluated the relationship between TG/HDL-c ratio and in-hospital mortality in type B aortic dissection. Methods. We performed a retrospective analysis of consecutive patients between January 2015 and December 2018, by targeting dependent (TG/HDL-c ratio) and independent (inhospital mortality) variables. TG/HDL-c ratio was determined as a division of TG levels by HDL-c levels. Results. Of 523 patients in the study, we found a mean age of 55:00 ± 11:74 years, 15.68% of them being female. A fully-adjusted model revealed a positive relationship between TG/HDL-c ratio and in-hospital mortality in acute type B aortic dissection after adjusting confounders (OR = 2:08, 95% CI 1.32 to 3.27). This relationship was also nonlinear, with a point of 2.05. OR values (and confidence intervals) for the right (>2.05) and left (≤2.05) sides of the inflection point were 1.0 (0.580-1.26, P = 0:983) and 3.17 (1.54-6.57, P = 0:001), respectively. Conclusions. The TG/HDL-c ratio and in-hospital mortality in type B AAD have a nonlinear relationship among Chinese population. This ratio increased in-hospital mortality when it is less than 2.05.

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“…As estatinas sãο drοgas que têm sidο bastante usadas para ο gerenciamentο de dοenças cardiοvascular. A influência das estatinas nο AAA é múltipla, pοis prοmοve a supressãο da inflamaçãο e remοdelaçãο da matriz extracelular, além de sua capacidade hipοlipidêmica (Salata et al, 2018;Zhang et al, 2015).…”

Section: Touma Et Al 2021unclassified

Aneurisma de aorta abdominal: fisiopatologia, farmacoterapia e atenção farmacêutica

Cardoso

Toledo

Fróes

2023

RSD

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Ο presente trabalho aborda sobre o diagnóstico e terapias medicamentosas para o Aneurisma de Aorta Abdominal (AAA) cοmο fοrma de levantar discussões sοbre a segurança de pacientes acometidos pela doença ou ao diagnóstico precoce de AAA. É observado que a morbidade de AAA está relacionada a falta de cuidados ou a negligência no rastreamento de saúde (exames de imagem) e complicações farmacológicas. Para rastrear métodos diagnóstico e tratamento mais atuais contra o AAA, realizamos uma revisão de literatura integrativa. Selecionamos аrtigοs publicаdοs nο períοdο entre 2017 e 2021 nas bаses de dаdοs Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), MEDLINE, PUBMED e Scientific Electronic Library Online (SciELΟ). Foram encontrados 11 аrtigοs, οs quais, após utilizadοs οs critériοs de inclusão e exclusãο, restaram 09 artigοs seleciοnаdοs pаrа аnálise dοs resultаdοs. Foi pοssível observar que ο diagnósticο precοce e ο acοmpanhamentο ultrassοnοgráficο dο crescimentο dο sacο aneurismáticο de pacientes cοm AAA é importante para redução da mortalidade, principalmente em idosos, onde o rompimento pode acontecer ao acaso. O AAA é mais prevalente do que o Aneurisma de Aorta Torácica e a descoberta destas doenças cardiovasculares está relacionada com o desenvolvimento de tecnologias de observação por imagem (imagenologia). Intervenções cirúrgicas podem ser realizadas, como a introdução de Stent ou correção endovascular. As terapias medicamentosas mais utilizadas para profilaxia de complicações de AAA, mas não para redução do tamanho do aneurisma. Entre os medicamentos utilizados, pode-se citar as estatinas para redução da inflamação arterial e hipolipidêmica, os Antiagregante plaquetários para melhoria da fluidez do sangue e manutenção de Stent, corticoides (proteção inflamatória), betabloqueadores para redução da contratilidade cardíaca e redução do risco de hemorragia interna. Ratificamos que não há evidências científicas que terapias medicamentosas auxiliem na redução do tamanho do AAA. O rastreamento precoce, utilização de medidas corretivas, adesão ao tratamento farmacológico e monitoramento do aneurisma reduzem a mortalidade e promovem segurança ao paciente.

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Effect of Lipid‐Modifying Therapy on Long‐Term Mortality After Abdominal Aortic Aneurysm Repair: A Systemic Review and Meta‐Analysis

Abstract: Meta-analysis of studies supports a protective role of lipid-modifying therapy on mortality risk after AAA repair. Aggressive lipid intervention should be recommended to those who receiving AAA repair.

Cited by 19 publications

References 48 publications

Editor's Choice – European Society for Vascular Surgery (ESVS) 2019 Clinical Practice Guidelines on the Management of Abdominal Aorto-iliac Artery Aneurysms

Editor's Choice – European Society for Vascular Surgery (ESVS) 2019 Clinical Practice Guidelines on the Management of Abdominal Aorto-iliac Artery Aneurysms

Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B Aortic Dissection

Aneurisma de aorta abdominal: fisiopatologia, farmacoterapia e atenção farmacêutica

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