Effect of lipid peroxides and antioxidants on glycation of hemoglobin: An in vitro study on human erythrocytes

Alleviation of Dimethylnitrosamine-Induced Liver Injury and Fibrosis by Supplementation of Anabasis articulata Extract in Rats

“…A similar effect was also found in the protective and therapeutic effects of silymarin in DMNintoxicated rats [42].…”

“…It has a main role in an increasing the expression of ECM and activating protein kinase C, thus plays a central role in tissue fibrosis [5]. Previously it was demonstrated that, protein glycation is considered as one of the causative factors in the etiology of tissue fibrosis [42].…”

Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c

“…46,47 Whereas some authors interpret data as indicating minimal biologic variation in HbA1c between individuals, 4 others have found evidence for more marked differences resulting from poorly understood genetic factors. 48,49 After the elucidation of the nature of nonenzymatic glycation, 50,51 glycation rates have been shown to be subject to variation between individuals by factors that are independent of glucose concentration, including pH, 32 inorganic phosphate, 52 oxidative stress, 53 deglycation, 43,54 and Schiff base inhibitors. 55 These techniques used here, in combination with frequent blood glucose sampling, could evaluate the importance of these factors.…”

A Case of Inappropriately High Glycated Hemoglobin

“…Corticosteroids like prednisone, anti seizure medications like phenytoin, antiviral medication used to treat human immunodeficiency virus, including fosamprenavir and saquinavir can elevate HbA1c in absence of diabetes mellitus. Malondialdehyde, which is increased in patients with iron deficiency anemia, enhances the glycation of hemoglobin [8]. Conditions that affect erythrocyte turnover (hemolysis, blood loss) and hemoglobin variants must be considered, particularly when the A1c result does not correlate with the patients clinical situation [9].…”