Effect of lipid shell composition in DSPG-based microbubbles on blood flow imaging with ultrasonography

Maruyama, Tamotsu; Sugii, Mutsumi; Omata, Daiki; Unga, Johan; Shima, Tadamitsu; Munakata, Lisa; Kageyama, Saori; Hagiwara, Fumiko; Suzuki, Yachiyo; Maruyama, Kazuo; Suzuki, Ryo

doi:10.1016/j.ijpharm.2020.119886

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…SNZ and SNV are both based on the principle of harmonic signal of contrast agent microbubbles, but SNZ shell is a stable and negatively charged liposome component (34), which can simulate the distribution of liposomes on the surface of cell membrane and is easy to be engulfed by Kupffer cells in liver, while SNV has no such characteristics. Yanagisawa et al (35) found that the phagocytic rate of SNZ on Kupffer cells was 99.00%, while that of SNV on Kupffer cells was only 7.30%.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of two contrast agents for intraoperative identification of sentinel lymph nodes in patients with early breast cancer

et al. 2021

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Background: The use of contrast-enhanced ultrasound (CEUS) to locate sentinel lymph nodes (SLNs) in breast cancer has been studied more and more in recent years. This prospective study aimed to compare periareolar injection of two different contrast agents, SonoVue ® (SNV) and Sonazoid ® (SNZ), followed by CEUS to identify SLNs in breast cancer patients with clinically negative nodes.Methods: A total of 205 patients with T1-2N0M0 breast cancer were divided into the SNV group and SNZ group. All were administered a periareolar injection of SNV or SNZ and underwent US to identify contrast-enhanced SLNs. Each contrast-enhanced SLN underwent a biopsy with blue dye and examined again by CEUS in vitro.Results: In all cases, contrast-enhanced lymphatic vessels were clearly visualized using US soon after the periareolar injection of SNZ, and the SLNs were easily identified. The SLN identification rates were 75.27% (210/279) for SNV and 93.58% (102/109) for SNZ. Although the accuracy of detecting SLN metastasis was slightly different between the two groups, there was no statistically significant difference between those groups (P=0.615). Moreover, it was possible to identify SLNs in vitro in the SNZ group, and these could be compared with the lymph nodes (LNs) located using SNZ during the preoperative stage and with blue dye during the procedure. This helped in determining the resection requirements.Conclusions: When comparing the subdermal use of SNV and SNZ, no significant differences in the number of detected SLNs and the diagnosis of metastatic LNs were observed. Because SLNs can be detected for a longer time in living tissues with SNZ, this contrast agent may provide more intraoperative information for complete resection of all preoperative localization of SLN.

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Section: Discussionmentioning

confidence: 99%

Comparative study of two contrast agents for intraoperative identification of sentinel lymph nodes in patients with early breast cancer

et al. 2021

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“…The average diameter of the MBs was approximately 1.4 µm based on number distribution. We have optimized the lipid outer shell and inner gas of the MBs in terms of their stability and drug delivery efficiency to the brain [27,28]. In this study, the optimized MBs were utilized.…”

Section: Preparation Of Mbsmentioning

confidence: 99%

“…We have previously reported the development of MBs with an outer shell composed of lipids [25]. We also examined whether opening the BBB using MBs and US could be considered minimally invasive and efficient for drug delivery to the brain by investigating US irradiation conditions and inner gas types [26][27][28]. Therefore, we hypothesized that opening the BBB using MBs combined with US would allow CDDP to cross the BBB and reach the tumor tissue to exert its antitumor effect.…”

Section: Introductionmentioning

confidence: 99%

Brain Delivery of Cisplatin Using Microbubbles in Combination with Ultrasound as an Effective Therapy for Glioblastoma

Hagiwara,

Omata,

Munakata

et al. 2023

Pharmaceuticals

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Glioblastoma is a highly invasive and fatal disease. Temozolomide, a blood–brain barrier (BBB)-penetrant therapeutic agent currently used for glioblastoma, does not exhibit sufficient therapeutic effect. Cisplatin (CDDP), a versatile anticancer drug, is not considered a therapeutic option for glioblastoma due to its low BBB permeability. We previously investigated the utility of microbubbles (MBs) in combination with ultrasound (US) in promoting BBB permeability and reported the efficacy of drug delivery to the brain using a minimally invasive approach. This study aimed to evaluate the feasibility of CDDP delivery to the brain using the combination of MBs and US for the treatment of glioblastoma. We used mice that were implanted with glioma-261 GFP-Luc cells expressing luciferase as the glioblastoma model. In this model, after tumor inoculation, the BBB opening was induced using MBs and US, and CDDP was simultaneously administered. We found that the CDDP concentrations were higher at the glioblastoma site where the US was applied, although CDDP normally cannot pass through the BBB. Furthermore, the survival was longer in mice treated with CDDP delivered via MBs and US than in those treated with CDDP alone or those that were left untreated. These results suggest that the combination of MBs and US is an effective antitumor drug delivery system based on BBB opening in glioblastoma therapy.

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Ultrasound and microbubble-mediated drug delivery and immunotherapy

et al. 2022

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Effect of lipid shell composition in DSPG-based microbubbles on blood flow imaging with ultrasonography

Cited by 4 publications

References 37 publications

Comparative study of two contrast agents for intraoperative identification of sentinel lymph nodes in patients with early breast cancer

Comparative study of two contrast agents for intraoperative identification of sentinel lymph nodes in patients with early breast cancer

Brain Delivery of Cisplatin Using Microbubbles in Combination with Ultrasound as an Effective Therapy for Glioblastoma

Ultrasound and microbubble-mediated drug delivery and immunotherapy

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