Effect of Liposome-Encapsulated Dextrazide on Local Regulation of Extracellular Matrix Metabolism in Liver and Lungs of Mice with during Chronic BCG-Induced Granulomatosis

Kim, L. B.; Putyatina, A. N.; Russkikh, G. S.; Shkurupy, V. A.

doi:10.1007/s10517-021-05123-5

Cited by 1 publication

(2 citation statements)

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“…Intravenous infecting of C57BL/6 mice with virulent Mtb Erdman strain leads to differential expression of MMPs in the lungs [121]. The activity of MMP-9 increased by 1 week after infection, while the activity of MMP-2 after 2 weeks.…”

Section: Mmps/timpsmentioning

confidence: 98%

“…Reverse transcription polymerase chain reaction (RT-PCR) analysis for the expression of gelatinase genes and their corresponding inhibitors showed a slight increase in MMP-9 by 1 week, no changes were observed in TIMP-1 and MMP-2, as well as a significant decrease in TIMP-2 by 4 weeks. According to the authors [121], glycolipid lipoarabinomannan and other Mtb components induce the expression of MMP-9. In the mouse model of BCG-induced inflammation, 6 months after infection, the total activity of MMPs increased by 9 times, hyaluronidase by 4 times, α2-MG by 10 times, TIMP-1 by 11 times, and TIMP-2 by 13 times in the lungs [122,123], that indicates high both protease and antiprotease activity of enzymes.…”

Section: Mmps/timpsmentioning

confidence: 99%

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Mechanism of lungs fibrosis in mycobacterial infection

Kim,

Putyatina

2023

Exploration of Medicine

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Lung tuberculosis (TB) remains a heavy burden on public health worldwide. This review discusses mainly the mechanisms of the development of pulmonary fibrosis in an experimental TB model in mice. The involvement of individual components of the extracellular matrix, the activity of matrix metalloproteinases, and the role of their tissue inhibitors in the fibrosis development. The current TB therapy activates fibrosis along with anti-mycobacterial action. The paper describes the authors’ results of experimental use of the liposome-encapsulated dextrazid (LЕDZ) combined with isoniazid (INH) which has both antifibrotic and anti-mycobacterial effects to be considered for future treatment.

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Section: Mmps/timpsmentioning

confidence: 98%