Effect of liposome size on peritoneal retention and organ distribution after intraperitoneal injection in mice

Hemisynthetic trifluralin analogues incorporated in liposomes for the treatment of leishmanial infections

“…Specifically, the TFL-A3 analogue after being incorporated in liposomes was responsible for more than 95% reduction of parasite growth in the spleen of treated mice, and 48% in the liver. These results are in accordance with the biodistribution profile of conventional liposomes after intraperitoneal administration, as it was reported a higher accumulation in spleen as compared to liver [37]. This tendency leads to an increase amount of TFL-A in this organ which was translated into a stronger reduction of parasite growth.…”

Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis — Mission possible?

“…When neutral liposomes were used, Mirahmadi concluded that 1000 nm sized particles were the most optimal to achieve high peritoneal retention [65]. Dadashzadeh et al, however, looked into the effect of size, charge, lipid composition and PEG coating on peritoneal retention in healthy female NMRI mice using 100 nm and 1000 nm radiolabeled liposomes [66].…”

Proliposomes containing a bile salt for oral delivery of Ginkgo biloba extract: Formulation optimization, characterization, oral bioavailability and tissue distribution in rats

“…This pattern of distribution may be due to uptake Table 4 Pharmacokinetics parameters of seven components in rat following an oral administration of GbE and proliposome formulations respectively (mean ± SD, n = 6). of liposomes by the reticuloendothelial system (Gula et al, 2013;Mirahmadi et al, 2010;Yan et al, 2015). Meanwhile, the much higher distribution (p < 0.01) of the drug in the brain following administration of proliposomes compared to that of control GbE could be beneficial therapeutically, when GbE is used for the treatment of cerebral diseases.…”