Effect of liposomes and niosomes on skin permeation of enoxacin

Fang, Jia You; Hong, Chi Tzong; Chiu, Wen Ta; Wang, Ying Yue

doi:10.1016/s0378-5173(01)00627-5

Cited by 256 publications

(131 citation statements)

References 29 publications

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“…Also, the overall lesion improvement during the whole study period was in favor of F13 formulae (Table 5 and Figure 4). These results could be attributed to the enhanced penetration of tretinoin from liposomes across the stratum courneum when compared to conventional dosage form (Fang et al, 2001;Jung et al, 2006;Lee et al, 2007;Jaafari et al, 2009;Duangjit et al, 2011).…”

Section: Clinical Studymentioning

confidence: 97%

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

et al. 2015

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Topical tretinoin is the most commonly used retinoid for acne. However, its irritative potential on the applied area and the barrier properties of the stratum corneum limit its use. The objective of the present study was to formulate tretinoin liposomal gel to obtain a formula with lower skin irritation potential and greater clinical effect. A statistical 2 4 factorial design was adopted. Sixteen formulae prepared and were properly evaluated. A candidate formula (F13G) prepared with 0.025% tretinoin, phospholipid-cholesterol-dicetylphosphate (9:1:0.01) and incorporated in 1% carbopol gel was selected for skin irritation test. Clinical study was conducted on acne patients and compared to marketed product. All liposomes formulations were spherical in shape. The addition of cholesterol in the film hydration method significantly decreased the vesicle size, and increased the percentage of incorporation efficiency at (p50.05). The presence of dicetylphosphate significantly increased drug release but did not affect the percentage of incorporation efficiency and vesicle size. The results of the clinical study in acne patients revealed that F13G showed significantly higher efficacy when compared to marketed product (p50.05).

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Section: Clinical Studymentioning

confidence: 97%

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

et al. 2015

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“…This could be attributed to the fact that, surfactant in formulation acts as a permeation enhancer. Another explanation is that niosomes can fuse at the interface of stratum corneum leading to the generation of high local drug concentration in the bilayers with high thermodynamic drug activity (Fang et al, 2001). …”

Section: Clinical Studymentioning

confidence: 99%

Formulation of tretinoin-loaded topical proniosomes for treatment of acne:in-vitrocharacterization, skin irritation test and comparative clinical study

et al. 2014

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Tretinoin (TRT) is a widely used retinoid for the topical treatment of acne, photo-aged skin, psoriasis and skin cancer which makes it a good candidate for topical formulation. Yet side effects, like redness, swelling, peeling, blistering and, erythema, in addition to its high lipophilicity make this challenging. Therefore, the aim of this study was the development of TRT-loaded proniosomes to improve the drug efficacy and to increase user acceptability and compliance by reducing its side effects. Nine formulae were prepared according to 3 2 factorial design and were evaluated for their morphology, vesicle size, entrapment efficiency (EE %), and% of drug released after 5 h. Hydrogel of the candidate formula, N8G (proniosomes prepared with 0.025% TRT, and Span60: cholesterol molar ratio of 3:1 and incorporated in 1% carbopol gel) was developed and evaluated for skin irritation test and clinical study in acne patients compared to marketed product. Candidate formula showed higher efficacy and very low irritation potential when compared to marketed product in human volunteers.

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“…31 On the other hand, liposomes may interact with the cell membranes and disorder the membrane properties. 32 It was shown that, the permeability barrier of the stratum corneum was weakened by phosphatidylcholine. 33 Makabi-Panzu et al 34 reported that incorporation of Q10 in liposomes enhanced the cellular uptake by macrophage cells.…”

Section: Resultsmentioning

confidence: 99%

A comparative evaluation of coenzyme Q10-loaded liposomes and solid lipid nanoparticles as dermal antioxidant carriers

Gökçe¹,

Korkmaz²,

Tanrıverdi³

et al. 2012

IJN

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Background:The effective delivery of coenzyme Q10 (Q10) to the skin has several benefits in therapy for different skin pathologies. However, the delivery of Q10 to deeper layers of skin is challenging due to low aqueous solubility of Q10. Liposomes and solid lipid nanoparticles (SLN) have many advantages to accomplish the requirements in topical drug delivery. This study aims to evaluate the influence of these nanosystems on the effective delivery of Q10 into the skin. Methods: Q10-loaded liposomes (LIPO-Q10) and SLNs (SLN-Q10) were prepared by thin film hydration and high shear homogenization methods, respectively. Particle size (PS), polydispersity index (PI), zeta potential (ZP), and drug entrapment efficiency were determined. Differential scanning calorimetry analysis and morphological transmission electron microscopy (TEM) examination were conducted. Biocompatibility/cytotoxicity studies of Q10-loaded nanosystems were performed by means of cell culture (human fibroblasts) under oxidative conditions. The protective effect of formulations against production of reactive oxygen species were comparatively evaluated by cytofluorometry studies. Results: PS of uniform SLN-Q10 and LIPO-Q10 were determined as 152.4 ± 7.9 nm and 301.1 ± 8.2 nm, respectively. ZPs were −13.67 ± 1.32 mV and −36.6 ± 0.85 mV in the same order. The drug entrapment efficiency was 15% higher in SLN systems. TEM studies confirmed the colloidal size. SLN-Q10 and LIPO-Q10 showed biocompatibility towards fibroblasts up to 50 µM of Q10, which was determined as suitable for cell proliferation. The mean fluorescence intensity % depending on ROS production determined in cytofluorometric studies could be listed as Q10 $ SLN-Q10 . LIPO-Q10. Conclusion: The LIPO-Q10 system was able to enhance cell proliferation. On the contrary, SLN-Q10 did not show protective effects against ROS accumulation. As a conclusion, liposomes seem to have advantages over SLN in terms of effective delivery of Q10 to skin for antioxidant purposes.

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Effect of liposomes and niosomes on skin permeation of enoxacin

Cited by 256 publications

References 29 publications

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

Formulation of tretinoin-loaded topical proniosomes for treatment of acne:in-vitrocharacterization, skin irritation test and comparative clinical study

A comparative evaluation of coenzyme Q10-loaded liposomes and solid lipid nanoparticles as dermal antioxidant carriers

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