Effect of liposomes on platelet function

Berdichevskii, V. R.; Markosyan, R. A.; Pozin, E. Ya.; Смирнов, В. Н.; Suvorov, A. V.; Торчилин, В. П.; Chazov, E. I.

doi:10.1007/bf00869205

Cited by 2 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been demonstrated that liposomes are able to induce (119)(120)(121) as well as inhibit (122,123) aggregation of platelets. The types of phospholipids in the membrane of the liposomes (124)(125)(126) and the surface charge of these vesicles (119)(120)(121)(122)(123) seem to play a role in the procoagulatory properties. Platelet aggregation in vitro and rat thrombosis in vivo was reported to be induced by carbon nanoparticles (127), whereas neutral and PEG-coated surfactant-based nanoparticles did not induce platelet activation in vitro (128).…”

Section: Platelet Activationmentioning

confidence: 99%

“…Platelet aggregation in vitro and rat thrombosis in vivo was reported to be induced by carbon nanoparticles (127), whereas neutral and PEG-coated surfactant-based nanoparticles did not induce platelet activation in vitro (128). Liposomes with a negative surface charge have been reported to increase as well as inhibit platelet aggregation (120)(121)(122)(123).…”

Section: Platelet Activationmentioning

confidence: 99%

See 1 more Smart Citation

Immunological Risk of Injectable Drug Delivery Systems

et al. 2009

View full text Add to dashboard Cite

Abstract. Injectable drug delivery systems (DDS) such as particulate carriers and water-soluble polymers are being used and developed for a wide variety of therapeutic applications. However, a number of immunological risks with serious clinical implications are associated with administration of DDS. These immunological events can compromise the efficacy and safety of these systems by changing the pharmacokinetics, biodistribution and targeting capability of DDS, and by inducing hypersensitivity reactions. Antibodies induced by administration of DDS can be directed against the carrier material, the drug and/or targeting ligands associated with the DDS. Complement activation and opsonization of DDS, which may or may not be associated with antibody formation, may lead to accelerated clearance, hypersensitivity reactions and formation of membrane attack complexes resulting in premature release of the drug. Also platelets have been reported to play a role in DDS immunogenicity. Despite our curtailed understanding of the relationships between physicochemical characteristics and immunogenicity of DDS, several risk factors have been identified. Insight into these factors should be employed in the development of novel DDS with low immunological risk.

show abstract

Section: Platelet Activationmentioning

confidence: 99%

Section: Platelet Activationmentioning

confidence: 99%

Immunological Risk of Injectable Drug Delivery Systems

et al. 2009

View full text Add to dashboard Cite

show abstract

Effect of liposomal surface charge on the pharmacokinetics of an encapsulated model compound

Abraham

Goundalkar

Mezei

1984

Biopharm & Drug Disp

View full text Add to dashboard Cite

The pharmacokinetics of 3H-Triamcinolone Acetonide-21-palmitate entrapped in liposomes with neutral, negative and positive surface charge was investigated in the male New Zealand White rabbit after a single intravenous bolus injection. Drug concentration-time data monitored in whole blood showed bi-exponential decay and were analysed by a least-squares regression analysis procedure to obtain pertinent pharmacokinetic parameters. The significance of the observed differences in the pharmacokinetics after administration of each type of liposome was assessed by the Analysis of Variance test method. Significant differences (p less than 0.05) were found in alpha, beta, (t 0.5)alpha, K12, and Vc. Positive liposomes apparently encountered a larger initial apparent volume of distribution than the neutral or negative type, and consequently exhibited demonstrably lower initial blood drug concentration, (Cb)0. Liposomes with different surface properties were removed from circulation at different rates and this resulted in significant difference (p less than 0.01) in the concentration of circulating liposomes an hour following injection of each type of liposome. A mean of 66 per cent of the initial concentration of positive liposomes remained in circulation an hour after injection whereas 11 and 23 per cent respectively of the neutral and negative type remained in circulation during the same time period. Liposomes with different surface properties apparently exhibited similar total body clearance of the encapsulated compound.

show abstract

Effect of liposomes on platelet function

Cited by 2 publications

References 14 publications

Immunological Risk of Injectable Drug Delivery Systems

Immunological Risk of Injectable Drug Delivery Systems

Effect of liposomal surface charge on the pharmacokinetics of an encapsulated model compound

Contact Info

Product

Resources

About