Effect of lithium on organic ion transport in rat kidney cortical slices.

Gemba, Munekazu; Mikuriya, Naoko; Tachibana, Akemi; Nakajima, Mayumi

doi:10.1254/jjp.34.128

Cited by 7 publications

(6 citation statements)

References 18 publications

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“…Previous studies showed that addition of lithium to an incubation medium resulted in inhibition of PAH accumulation in rat kidney cortical slices, but had no detectable effect on TEA accumulation in vitro (4). Evidence for the in vivo effect of lithium on PAH transport in kidney was obtained in the present study using the renal clearance technique and the kidney cortical slice technique.…”

Section: Discussionsupporting

confidence: 65%

“…The effect of lithium on p-aminohip purate (PAH) transport, one of the functions of proximal tubules in the kidney (3), was shown in our previous report (4), in which lithium decreased the accumulation of PAH, as a prototype for organic anions, in rat kidney cortical slices in vitro, whereas lithium had no effect on that of tetraethyl ammonium (TEA), as a prototype for organic cations, in the slices. Our previous work has cast doubt on a conclusion in a recent study reporting that the inhibitory effect of lithium on tubular PAH transport may be indirect via raising plasma 2-oxoglutarate, an inhibitor of PAH transport (5).…”

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confidence: 91%

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Evidence for in Vivo Effect of Lithium on p-Aminohippurate Transport in Rat Kidney, Preliminary Study

Sugihara¹,

Tachibana²,

Gemba³

1985

Japanese Journal of Pharmacology

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Abstract-We examined the effect of lithium on rat renal handling of p-amino hippurate (PAH) and accumulation of organic ions by rat kidney cortical slices. When infused intravenously with lithium at the rate of 0.13 mmoles/kg/min, de creased renal clearance of PAH as well as no significant changes in glomerular filtration rate and plasma PAH level was observed at the first clearance period during lithium infusion.As we expected, tubular secretion of PAH also was decreased sig nificantly by the infusion of lithium. Therefore, it is suggested that the decrease in the clearance of PAH was due to the decrease in the tubular secretion of PAH. After four days of injections with lithium (4 mmoles/kg, i.p., once a day), a sig nificant decrease in PAH accumulation in the slices was detected.No inhibition of tetraethylammonium accumulation was observed. Lithium pretreatment did not alter water content and extracellular space of the slices. The results suggest that lithium selectively inhibits the organic anion transport system in kidney with the in vivo treatment and follows our previous work in which we showed the in vitro effect of lithium on organic anion accumulation in the slices.

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Section: Discussionsupporting

confidence: 65%

mentioning

confidence: 91%

Evidence for in Vivo Effect of Lithium on p-Aminohippurate Transport in Rat Kidney, Preliminary Study

Sugihara¹,

Tachibana²,

Gemba³

1985

Japanese Journal of Pharmacology

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“…TEA is extensively accumulated in rat kidney cortical slices in vitro [6], and in an in vivo study Mintun et al [12] found that the maximal tissue-to-plasma ratio of TEA in whole-kidney tissue -about 13 -was not at tained until 5 h after intravenous administra tion of 2 mg of TEA to rats. In the present study we used only tracer doses of TEA in order to avoid undesired effects related to its properties as a ganglionic blocking agent, and the estimated infusion rate was as low as 0.6 mg kg-1 h_l.…”

Section: Discussionmentioning

confidence: 99%

Tetraethylammonium and <i>ρ</i><i>-</i>Aminohippurate as Clearance Markers for Renal Plasma Flow in the Rat during Saline and Glucose Infusion

Rasmussen

Shalmi²,

Hansen³

et al. 1990

Kidney Blood Press Res

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Renal plasma clearances (C) of ¹⁴C-tetraethylammonium (TEA) and ρ-aminohippurate (PAH) as estimates of arterial renal plasma flow (ARPF) were evaluated in anesthetized rats during control conditions and during intravenous glucose infusion. Venous renal blood flow was measured directly by means of a servo-controlled pump, keeping the renal venous pressure constant. Arteriovenous extraction fractions (E = 1 – P_renal_venous/P_renal_arterial) for PAH averaged 88.3 ± (SE) 0.8% in control rats and 82.0 ± 0.9% in glucose-infused rats (p < 0.001); E_TEA averaged 92.0 ± 0.6 and 90.1 ± 0.6%, respectively (p < 0.05). Under both experimental conditions, (C/E)_PAHdid not differ significantly from ARPF, while (C/E)_TEA underestimated ARPF; the rate of extraction of TEA exceeded the rate of excretion by 15–20%, probably due to accumulation of TEA in renal tissue. It is concluded that, when corrected for E, C_PAh is in general a more accurate estimate for ARPF than C_TEA. However, under conditions involving changes in plasma glucose levels C_Tea may provide a better estimate of the effective renal plasma flow than C_PAH.

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“…In summary, the use of TEA offers several advantages compared to PAH. Whereas furosemide, Li, and glucose inhibits PAH transport, these interventions have no effect on TEA secretion (I; Rennick 198 1 ;Gemba et al 1984;Rasmussen et al 1990). In contrast to the severe reduction of EPAH during chronic uremia (may be as low as 0.24), ETEA is unaffected by azotemia (Rose et al 1976;McNay et al 1976).…”

Section: ''C-tetraethylammonium As a Marker For Renal Plasma Flow Durmentioning

confidence: 99%

Interactions Between Furosemide and the Renal Sympathetic Nerves

Petersen¹

1999

Pharmacology & Toxicology

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Effect of lithium on organic ion transport in rat kidney cortical slices.

Cited by 7 publications

References 18 publications

Evidence for in Vivo Effect of Lithium on p-Aminohippurate Transport in Rat Kidney, Preliminary Study

Evidence for in Vivo Effect of Lithium on p-Aminohippurate Transport in Rat Kidney, Preliminary Study

Tetraethylammonium and <i>ρ</i><i>-</i>Aminohippurate as Clearance Markers for Renal Plasma Flow in the Rat during Saline and Glucose Infusion

Interactions Between Furosemide and the Renal Sympathetic Nerves

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