Effect of Liver Resection on the Progression and Growth of Rhabdomyosarcoma Metastases in a Rat Model

Garcı́a-Alonso, Ignacio; Palomares, Teodoro; Alonso, Ana; Echenique-Elizondo, Miguel; Carames, Juan C.; Castro, Begoña; Méndez, Jaime

doi:10.1016/j.jss.2007.06.026

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…Our result was consistent with previous reports [21,22], which implied that patients with HCC could benefit from palliative resection. In contrast, some studies have reported that partial hepatectomy accelerates tumor growth and stimulates tumor metastasis [3-7]. Our experimental research revealed that palliative resection is followed by acceleration of metastatic processes in the lungs.…”

Section: Discussionmentioning

confidence: 61%

“…However, even in patients undergoing curative resection, the procedure is only potentially curative due to the existence of tumor cells or clinically undetectable residual intrahepatic lesions [2,3]. Our clinical observation showed that after palliative resection the patients experienced dramatically increased metastases without systemically effective treatments from the oncologic standpoint.…”

Section: Discussionmentioning

confidence: 88%

“…However, the influence of liver resection on tumor growth and metastasis remains controversial. Increasing numbers of reports indicate that partial hepatectomy accelerates tumor growth and stimulates tumor metastasis [3-7], although one report claimed that major hepatic resection may suppress the growth of tumors remaining in the residual liver [8]. Another report indicated that hepatectomy prolongs survival of mice with induced liver metastases [9].…”

Section: Introductionmentioning

confidence: 99%

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Herbal compound "Songyou Yin" reinforced the ability of interferon-alfa to inhibit the enhanced metastatic potential induced by palliative resection of hepatocellular carcinoma in nude mice

Huang

Wang

et al. 2010

BMC Cancer

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BackgroundLiver resection is a widely accepted treatment for hepatocellular carcinoma (HCC). Our previous clinical study showed that the rate of palliative resection was 34.0% (1958-2008, 2754 of 8107). However, the influence of palliative resection on tumor metastasis remains controversial. The present study was conducted to evaluate the effect of palliative resection on residual HCC and to explore interventional approaches.MethodsPalliative resection was done in an orthotopic nude mice model of HCC (MHCC97H) with high metastatic potential. Tumor growth, invasion, metastasis, lifespan, and some molecular alterations were examined in vivo and in vitro. Mice that underwent palliative resection were treated with the Chinese herbal compound "Songyou Yin," interferon-alfa-1b (IFN-α), or their combination to assess their effects.ResultsIn the palliative resection group, the number of lung metastatic nodules increased markedly as compared to the sham operation group (14.3 ± 4.7 versus 8.7 ± 3.6, P < 0.05); tumor matrix metalloproteinase 2 (MMP2) activity was elevated by 1.4-fold, with up-regulation of vascular endothelial growth factor (VEGF) and down-regulation of tissue inhibitor of metalloproteinase 2 (TIMP2). The sera of mice undergoing palliative resection significantly enhanced cell invasiveness by 1.3-fold. After treatment, tumor volume was 1205.2 ± 581.3 mm3, 724.9 ± 337.6 mm3, 507.6 ± 367.0 mm3, and 245.3 ± 181.2 mm3 in the control, "Songyou Yin," IFN-α, and combination groups, respectively. The combined therapy noticeably decreased the MMP2/TIMP2 ratio and prolonged the lifespan by 42.2%. Moreover, a significant (P < 0.001) reduction of microvessel density was found: 43.6 ± 8.5, 34.5 ± 5.9, 23.5 ± 5.6, and 18.2 ± 8.0 in the control and treatment groups, respectively.ConclusionPalliative resection-stimulated HCC metastasis may occur, in part, by up-regulation of VEGF and MMP2/TIMP2. "Songyou Yin" reinforced the ability of IFN-α to inhibit the metastasis-enhancing potential induced by palliative resection, which indicated its potential postoperative use in patients with HCC.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Herbal compound "Songyou Yin" reinforced the ability of interferon-alfa to inhibit the enhanced metastatic potential induced by palliative resection of hepatocellular carcinoma in nude mice

Huang

Wang

et al. 2010

BMC Cancer

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“…2,3 However, this procedure suffers from a recurrence rate of 20-64% in the first year and 57-81% at 3 years after curative resection, because of the presence of tumor or undetected residual intrahepatic defects. 4,5 Therefore, prevention of recurrence for a relatively long term is particularly important for improving the success rate of surgery.…”

Section: Introductionmentioning

confidence: 99%

Synergistic mediation of tumor signaling pathways in hepatocellular carcinoma therapy via dual-drug-loaded pH-responsive electrospun fibrous scaffolds

Yuan

Zhao

et al. 2015

J. Mater. Chem. B

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All-trans-retinoic acid counteract the tumor-stimulating effect of hepatectomy and increases survival of rats bearing liver metastases

Palomares¹,

Garcı́a-Alonso²,

Isidro³

et al. 2014

Journal of Surgical Research

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Effect of Liver Resection on the Progression and Growth of Rhabdomyosarcoma Metastases in a Rat Model

Cited by 5 publications

References 29 publications

Herbal compound "Songyou Yin" reinforced the ability of interferon-alfa to inhibit the enhanced metastatic potential induced by palliative resection of hepatocellular carcinoma in nude mice

Herbal compound "Songyou Yin" reinforced the ability of interferon-alfa to inhibit the enhanced metastatic potential induced by palliative resection of hepatocellular carcinoma in nude mice

Synergistic mediation of tumor signaling pathways in hepatocellular carcinoma therapy via dual-drug-loaded pH-responsive electrospun fibrous scaffolds

All-trans-retinoic acid counteract the tumor-stimulating effect of hepatectomy and increases survival of rats bearing liver metastases

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