Effect of Local Administration of Hyaluronic Acid on Orthodontic Tooth Movement in a Rabbit Model

Abstract

INTRODUCTION:Using a biocompatible material to control tooth movement and enhance anchorage may be a useful method to help the orthodontist to give better treatment results. OBJECTIVES: To Assess the effect of hyaluronic acid (HA) local injection on orthodontic tooth movement. MATERIALS AND METHODS:The sample size was 15 male New Zealand rabbits. Randomized prospective split mouth trial was conducted on each rabbit. A mesializing force was applied in both sides for 21 days. Group A (control): Saline was injected on day 0. Group B: HA 1% was injected. Tooth movements were measured on 3D models. Histological analysis of alveolar bone modeling was done in the end of this experiment. RESULTS: The quadrant receiving HA showed less amount of tooth movement than that in the control quadrant. Local administration of HA yielded 10% less tooth movement. Histological analysis revealed less resorptive activity in the quadrant receiving HA. CONCLUSION: There was statistically significant reduction in orthodontic tooth movement magnitude after local HA administration as well as reduction in bone resorptive activity.