Effect of Local Application of Alendronate and Parathyroid Hormone on Craniofacial Bone Repair - a Preliminary Study

Deliberador, Frederico Ribeiro; Sebastiani, Aline Monise; Gerber, Jennifer Tsi; Bonetto, Luana Mordask; Tórtora, Gabriela; Giovanini, Allan Fernando; Deliberador, Tatiana Miranda; Zielak, João César; Scariot, Rafaela

doi:10.1590/0103-6440201802120

Cited by 6 publications

(6 citation statements)

References 36 publications

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“…A previous study observed that a dose of 3 mg/kg caused systemic alterations in animals, with hepatic impairment (28). In Deliberador et al (15) work, local applications of 1 mg/kg alendronate in rat calvaria defects were delivered, the authors concluded that the kidneys showed normal glomeruli, with capillaries surrounding these structures. No impact on the kidneys was observed in any group of their work.…”

Section: -Discussionmentioning

confidence: 97%

“…It is this phase that would bene t from the use of substances such as ALN, which have the potential to stimulate osteogenic action, reduce bone resorption activity, and assist in the consolidation process (1,(11)(12)(13). When combined with anabolic-active drugs, ALN signi cantly improves bone mineral density and reduces bone fracture (3,8,14,15). Previous research has shown that short-term ALN treatment also improves bone repair around implants installed in the tibias of osteoporotic rats, demonstrating the drug's potential therapeutic effect (16,17).…”

Section: -Backgroundmentioning

confidence: 99%

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Effects of alendronate in bone repair: A study in rat femur fractures treated with plates and screws

Tiboni¹,

Weiss²,

Gerber³

et al. 2020

Preprint

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Background Alendronate (ALN) has direct action on bone metabolism, increasing osteogenesis and decreasing bone resorption. The study rated the effect of ALN on femoral fracture repair and the effect of different doses of the drug on the liver and kidneys. Methods Wistar rats were divided into groups: A1 (ALN 1 mg/kg), A2 (ALN 3 mg/kg), and C (saline solution). The drug/solution was applied intraperitoneally three times a week after femoral fracture until euthanasia 45 days later. Results Liver analysis from group A1 presented normal histological aspects, while hepatic steatosis was observed in group A2. In groups A1 and A2, kidneys showed amylocymile like cell degeneration. In femur bone callus, no difference was observed in collagens I and III or in number of trabeculae (p ≥ 0.05). Immunohistochemical evaluation showed positivity for the Transforming Grow Factor β-1 (TGFβ-1) marker in the control group, in spinal area and in small chondrocytes, but negativity for hypertrophy. In A1, an extensive area of cartilaginous expansion was observed, with positive hypertrophic TGFβ-1 cartilage, even in areas with bone matrix. A low positivity was observed in the medullar area, in contrast to the control. Group A2 presented a high number of chondroid matrices and a moderate number of TGFβ-1 cells, with little positivity in medullary area. Conclusions A dosage of ALN 1 mg/kg promotes cellular differentiation activity in the bone callus region, with mild damage in the liver and kidneys. A dosage of ALN 3 mg/kg became toxic without positive alterations in cell differentiation.

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Section: -Discussionmentioning

confidence: 97%

Section: -Backgroundmentioning

confidence: 99%

Effects of alendronate in bone repair: A study in rat femur fractures treated with plates and screws

Tiboni¹,

Weiss²,

Gerber³

et al. 2020

Preprint

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“…In our study, we have tried to evaluate the response of enzyme activity of serum MMP-9 and TIMP-1 on appropriate treatment in postmenopausal osteoporosis, which must include pharmacological and nonpharmacological therapy. Taking into account the role of bisphosphonates in regulating activation pathways for MMPs in general and in osteoporosis [27,28], as well as the necessity of proscribing adequate exercise program, we were interested in the role of supervised exercise program in this regulation, specifically. We proposed that pharmacological and nonpharmacological "agents," working together, would have the ability to modulate MMPs activity in a period of 3 months.…”

Section: Discussionmentioning

confidence: 99%

Effects of 12-Week Exercise Program on Enzyme Activity of Serum Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Female Patients with Postmenopausal Osteoporosis: A Randomized Control Study

Filipović

Gopčević

Dimitrijević

et al. 2020

BioMed Research International

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Background. Osteoporosis is a disease characterized by decreased bone density and destruction of bone microarchitecture. Indicators for altered bone homeostasis are changes in the serum level of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). The purpose of the current study was to evaluate the effect of a 12-week exercise program on enzyme activity of serum MMP-9 and TIMP-1 in postmenopausal osteoporotic patients. Materials and methods. Participants were randomized in two groups: exercise (EG) (N = 37) and control (CG) (N = 31). The exercise group completed a 12-week supervised exercise program, while the control group did not take part in any physical activity. Enzyme activities of serum MMP-9 and TIMP-1 were detected by gelatin zymography and ELISA in both groups, respectively. Results. Significant differences between pretreatment and posttreatment enzyme activities of serum MMP-9 (p=0.009), TIMP-1 (p≤0.001), and MMP-9/TIMP-1 ratio (p≤0.001) were detected in the exercise group. Exercises decreased the activity of serum MMP-9 and increased the activity of TIMP-1, while the enzyme activities of MMP-9 (0.583) and TIMP-1 (0.210) have not been significantly changed in CG. Patients from the exercise group had better treatment. Conclusion. Our results suggest that a 12-week exercise program has an influence on enzyme activity of serum MMP-9, revealing a possible role of MMPs in initiating training-specific adaptation. Although measurements of circulating MMP-9 and TIMP-1 allowed us to detect effects of exercise, as of today, they have no real role in the diagnosis of osteoporosis and/or follow-up of osteoporotic patient’s response to treatment. MMP-9 might be used as an important prognostic marker for the evaluation of patient’s response to exercise. Larger-randomized controlled studies need to be performed to expand this area of knowledge. This trial is registered with trial registration number: NCT03816449).

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“…Como desvantagens, os ALN possuem baixa biodisponibilidade e apresentam efeitos colaterais quando administrados sistemicamente, seja por via oral ou intravenosa, como irritação gástrica e osteonecrose dos maxilares 3 . Portanto, o uso tópico de ALN torna-se uma opção atrativa, pois busca atingir altas concentrações locais do fármaco, eliminando ou minimizando os efeitos adversos indesejados 4 .…”

Section: Introductionunclassified

Alendronato de sódio tópico associado ao osso bovino liofilizado no reparo ósseo

OLIVEIRA

Bonatto

Rocha

et al. 2022

Rev. odontol. UNESP

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Resumo Introdução O osso bovino inorgânico é o enxerto mais utilizado na Odontologia, tendo como desvantagem longo tempo de integração ao leito receptor. Os bifosfonatos têm sido utilizados para modular a quantidade e a qualidade do osso regenerado e diminuir o tempo de integração do enxerto. Objetivo Avaliar o efeito do bifosfonato alendronato de sódio (ALN) 0,5%, associado ou não ao osso bovino inorgânico, na reparação de defeitos ósseos. Material e método Dois defeitos ósseos foram confeccionados na calvária de 12 coelhos, sendo a cavidade esquerda/experimental preenchida com: GI = osso bovino inorgânico (Bio-Oss®); GII = Bio-Oss® + ALN 0,5%; GIII = ALN 0,5%; e a cavidade direita por coágulo sanguíneo (controle). Os animais foram mortos aos 60 dias pós-operatórios. Por meio de análise histomorfométrica calculou-se o percentual de osso neoformado e remanescente do biomaterial em relação à área total do defeito. Resultado Osso neoformado: GI = 38,16 ± 15,44%; GII = 55,77 ± 16,75%; GII I = 60,28 ± 11,45%. Controle = 45,11 ± 11,09%. Remanescente do enxerto: GI = 7,02 ± 5,36% e GII = 16,59 ± 9,56%. Não houve diferença quanto ao percentual de osso neoformado entre os grupos (ANOVA p = 0,15512; teste de Tukey F = 2,089). O percentual de remanescente do enxerto também foi estatisticamente semelhante entre os grupos GI e GII (teste de Tukey F = 5,019). Conclusão O uso tópico da solução de ALN 0,5% isoladamente ou associado ao osso bovino liofilizado não alterou o percentual de neoformação óssea nem a degradação dos grânulos do enxerto.

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Effect of Local Application of Alendronate and Parathyroid Hormone on Craniofacial Bone Repair - a Preliminary Study

Cited by 6 publications

References 36 publications

Effects of alendronate in bone repair: A study in rat femur fractures treated with plates and screws

Effects of alendronate in bone repair: A study in rat femur fractures treated with plates and screws

Effects of 12-Week Exercise Program on Enzyme Activity of Serum Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Female Patients with Postmenopausal Osteoporosis: A Randomized Control Study

Alendronato de sódio tópico associado ao osso bovino liofilizado no reparo ósseo

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