Effect of local hyperthermia on lymph immune cells and lymphokines of normal human skin

Olszewski, Waldemar L.; Grzelak, I; Ziółkowska, Anna; Engeset, A

doi:10.1002/jso.2930410211

Cited by 19 publications

(7 citation statements)

References 11 publications

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“…Hyperthermia increases the pro-inflammatory cytokines IL-6 [5,6,12] and IL-1β [5,6,13]. This study’s results are consistent with the findings of studies showing heat-induced incremental increases in IL-6 and IL-1β.…”

Section: Discussionsupporting

confidence: 88%

Oligonol Supplementation Affects Leukocyte and Immune Cell Counts after Heat Loading in Humans

Lee

Shin

2014

Nutrients

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Oligonol is a low-molecular-weight form of polyphenol and has antioxidant and anti-inflammatory activity, making it a potential promoter of immunity. This study investigates the effects of oligonol supplementation on leukocyte and immune cell counts after heat loading in 19 healthy male volunteers. The participants took a daily dose of 200 mg oligonol or a placebo for 1 week. After a 2-week washout period, the subjects were switched to the other study arm. After each supplement, half-body immersion into hot water was made, and blood was collected. Then, complete and differential blood counts were performed. Flow cytometry was used to enumerate and phenotype lymphocyte subsets. Serum concentrations of interleukin (IL)-1β and IL-6 in blood samples were analyzed. Lymphocyte subpopulation variables included counts of total T cells, B cells, and natural killer (NK) cells. Oligonol intake attenuated elevations in IL-1β (an 11.1-fold change vs. a 13.9-fold change immediately after heating; a 12.0-fold change vs. a 12.6-fold change 1h after heating) and IL-6 (an 8.6-fold change vs. a 9.9-fold change immediately after heating; a 9.1-fold change vs. a 10.5-fold change 1h after heating) immediately and 1 h after heating in comparison to those in the placebo group. Oligonol supplementation led to significantly higher numbers of leukocytes (a 30.0% change vs. a 21.5% change immediately after heating; a 13.5% change vs. a 3.5% change 1h after heating) and lymphocytes (a 47.3% change vs. a 39.3% change immediately after heating; a 19.08% change vs. a 2.1% change 1h after heating) relative to those in the placebo group. Oligonol intake led to larger increases in T cells, B cells, and NK cells at rest (p < 0.05, p < 0.05, and p < 0.001, respectively) and immediately after heating (p < 0.001) in comparison to those in the placebo group. In addition, levels of T cells (p < 0.001) and B cells (p < 0.001) were significantly higher 1 h after heating in comparison to those in the placebo group. These results demonstrate that supplementation with oligonol for 1 week may enhance the immune function under heat and suggest a potential useful adjunct to chemotherapy in malignant diseases.

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Section: Discussionsupporting

confidence: 88%

Oligonol Supplementation Affects Leukocyte and Immune Cell Counts after Heat Loading in Humans

Lee

Shin

2014

Nutrients

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“…Skin tissue fluid is rich in various types of cytokines and growth factors with concentrations higher in the prenodal lymph than in serum, due to the local production by keratinocytes, lymphocytes and macrophages. 8,9 The question remains open as to which of the many cytokines and growth factors present in TF/L is or are responsible for the stimulation of KC stem cells as well as of transit amplifying cells (TA) and, subsequently, for excessive keratinocyte proliferation. Identification and subsequent neutralization of the responsible cytokine(s) by intralymphatically administrated antibodies could be a therapeutic way of preventing proliferation of keratinocytes in lymphedema.…”

Section: Introductionmentioning

confidence: 99%

Hyperkeratosis in human lower limb lymphedema: the effect of stagnant tissue fluid/lymph

Domaszewska-Szostek

Zaleska

2016

Acad Dermatol Venereol

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“…12,26 Hot beverages may also increase the temperature of the distal nares, which may improve the immune response. 27,28 Like iced tea, soda consumption did not affect the risk of MRSA nasal carriage. As many sodas are caffeinated, this fi nding suggests that caffeine is unlikely to be responsible for the antibacterial properties of hot tea and coffee.…”

Section: Discussionmentioning

confidence: 92%

Tea and Coffee Consumption and MRSA Nasal Carriage

Matheson

Mainous²,

Everett³

et al. 2011

The Annals of Family Medicine

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PURPOSE Hot tea and coffee have been found to have antimicrobial properties. The purpose of this study was to determine whether the consumption of tea, coffee, or both is associated with less frequent nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA). METHODSWe performed a secondary analysis of data from the [2003][2004] National Health and Nutrition Examination Survey to investigate the relationship between the consumption of coffee, hot tea, cold tea, and soft drinks, and MRSA nasal carriage among the noninstitutionalized population of the United States.RESULTS An estimated 2.5 million persons (1.4% of the population) were MRSA nasal carriers. In an adjusted logistic regression analysis controlling for age, race, sex, poverty-income ratio, current health status, hospitalization in the past 12 months, and use of antibiotics in the past month, individuals who reported consuming hot tea were one-half as likely to have MRSA nasal carriage relative to individuals who drank no hot tea (odds ratio = 0.47; 95% confi dence interval, 0.31-0.71). Similarly, individuals who reported consuming coffee had about a one-half reduction in the risk of MRSA nasal carriage relative to individuals who drank no coffee (odds ratio = 0.47; 95% confi dence interval, 0.24-0.93).CONCLUSIONS Consumption of hot tea or coffee is associated with a lower likelihood of MRSA nasal carriage. Our fi ndings raise the possibility of a promising new method to decrease MRSA nasal carriage that is safe, inexpensive, and easily accessible. INTRODUCTIONI nfection with methicillin-resistant Staphylococcus aureus (MRSA) is a major source of morbidity and mortality in the United States. In 2005, more than 278,000 Americans were hospitalized for MRSA-related infections, and there were more than 6,500 MRSA-related deaths.1 Studies have suggested that nasal carriage of MRSA may signifi cantly increase the risk of a MRSA infection, although this fi nding has not been universal. [2][3][4] In an effort to both prevent and treat MRSA, researchers have examined the antimicrobial effects of several commonly consumed plants and plant extracts. [5][6][7] Two of the most promising and ubiquitous are tea and coffee. [8][9][10] Tea has been found to have antimicrobial activity against several types of pathogenic bacteria, including Vibrio cholerae, Escherichia coli, Shigella, Salmonella, Like tea, coffee appears to have antimicrobial properties against Escherichia coli, Salmonella, and S aureus. 10,14 Both in vivo and in vitro studies have demonstrated that tea or tea-based extracts have antimicrobial properties when applied topically. 9,15 What remains unclear is whether tea and coffee have systemic antimicrobial activity when consumed orally as beverages.The purpose of this study was to evaluate the relationship between oral consumption of tea and coffee, and MRSA nasal carriage in a nationally representative sample of Americans. 17 The NHANES uses a complex survey design that allows for the determination of population estimates. To enable...

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Effect of local hyperthermia on lymph immune cells and lymphokines of normal human skin

Cited by 19 publications

References 11 publications

Oligonol Supplementation Affects Leukocyte and Immune Cell Counts after Heat Loading in Humans

Oligonol Supplementation Affects Leukocyte and Immune Cell Counts after Heat Loading in Humans

Hyperkeratosis in human lower limb lymphedema: the effect of stagnant tissue fluid/lymph

Tea and Coffee Consumption and MRSA Nasal Carriage

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