Comprehensive Physiology 1980
DOI: 10.1002/cphy.cp020217
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Effect of Local Metabolic Factors on Vascular Smooth Muscle

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Cited by 53 publications
(42 citation statements)
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References 251 publications
(115 reference statements)
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“…Of the local chemical compounds usually thought to play a role in vasodilatation (for reference see Sparks, 1980), we have measured oxygen, lactate (osmolarity) and pH. The Po2 tensions in the venous effluent changed the most going from rest to light exercise, but not much thereafter.…”
Section: Discussionmentioning
confidence: 99%
“…Of the local chemical compounds usually thought to play a role in vasodilatation (for reference see Sparks, 1980), we have measured oxygen, lactate (osmolarity) and pH. The Po2 tensions in the venous effluent changed the most going from rest to light exercise, but not much thereafter.…”
Section: Discussionmentioning
confidence: 99%
“…Oxygen availability is considered to one of the most important local factors influencing vascular contractility (Sparks, 1980). However, the effect of a decrease in oxygen tension is not uniform throughout the vascular system.…”
Section: Introductionmentioning
confidence: 99%
“…Blood oxygen content is known to be an important local factor in the regulation of circulation (for reviews see Sparks, 1980;Wadsworth, 1994). In systemic arteries a decrease in local 02 tension (Po2) normally leads to vasodilatation whereas hypoxia predominantly evokes the opposite response (vasoconstriction) in the pulmonary circulation (Dawson, 1984;Harder, Madden & Dawson, 1985a;Madden, Vadula & Kurup, 1992).…”
mentioning
confidence: 99%