Effect of locally delivered protein complex‐loaded nanoparticles on bone remodelling of atrophic alveolar ridge in beagles

Lee, Keun-Ha; Lee, Sang Cheon; Kim, Hye Jung; Kang, Yoon‐Goo; Kim, Su-Jung

doi:10.1111/ocr.12487

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…The rate of tooth movement in a narrow alveolar ridge is inhibited compared to when the teeth are moved to a location with sufficient bone 4 . Given that in our study force application led to bone dehiscence (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…In orthodontic treatment, the thickness of the alveolar bone defines one of the boundaries of the tooth movement. Tooth movement in a constricted alveolar ridge, including molar buccal expansion, space closure of extraction or missing sites in an atrophic alveolar ridge (AAR), and incisor labio-lingual movements, may cause undesirable collateral impacts such as bone dehiscence, gingival recession, root resorption and reduction in tooth movement rate 2 – 4 . The presence of bone dehiscence has been proven to jeopardise the aesthetic appearance of the periodontal tissue and negatively affect the long-term stability of orthodontic treatment 5 – 8 .…”

Section: Introductionmentioning

confidence: 99%

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Prevention of bone dehiscence associated with orthodontic tooth movement by prophylactic injection of bone anabolic agents in mice

Qi,

Matsumoto,

Xie

et al. 2024

Sci Rep

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Although bone dehiscence may occur during orthodontic tooth movement into the narrow alveolar ridge, a non-invasive prevention method is yet to be fully established. We show for the first time prevention of bone dehiscence associated with orthodontic tooth movement by prophylactic injection of bone anabolic agents in mice. In this study, we established a bone dehiscence mouse model by applying force application and used the granular type of scaffold materials encapsulated with bone morphogenetic protein (BMP)-2 and OP3-4, the receptor activator of NF-κB ligand (RANKL)-binding peptide, for the prophylactic injection to the alveolar bone. In vivo micro-computed tomography revealed bone dehiscence with decreased buccal alveolar bone thickness and height after force application, whereas no bone dehiscence was observed with the prophylactic injection after force application, and alveolar bone thickness and height were kept at similar levels as those in the control group. Bone histomorphometry analyses revealed that both bone formation and resorption parameters were significantly higher in the injection with force application group than in the force application without the prophylactic injection group. These findings suggest that the prophylactic local delivery of bone anabolic reagents can prevent bone dehiscence with increased bone remodelling activity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevention of bone dehiscence associated with orthodontic tooth movement by prophylactic injection of bone anabolic agents in mice

Qi,

Matsumoto,

Xie

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

Unraveling Nanomaterials in Biomimetic Mineralization of Dental Hard Tissue: Focusing on Advantages, Mechanisms, and Prospects

Dai,

Li,

Zhang

2024

Advanced Science

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The demineralization of dental hard tissue imposes considerable health and economic burdens worldwide, but an optimal method that can repair both the chemical composition and complex structures has not been developed. The continuous development of nanotechnology has created new opportunities for the regeneration and repair of dental hard tissue. Increasingly studies have reported that nanomaterials (NMs) can induce and regulate the biomimetic mineralization of dental hard tissue, but few studies have examined how they are involved in the different stages, let alone the relevant mechanisms of action. Besides their nanoscale dimensions and excellent designability, NMs play a corresponding role in the function of the raw materials for mineralization, mineralized microenvironment, mineralization guidance, and the function of mineralized products. This review comprehensively summarizes the advantages of NMs and examines the specific mineralization mechanisms. Design strategies to promote regeneration and repair are summarized according to the application purpose of NMs in the oral cavity, and limitations and development directions in dental hard tissue remineralization are proposed. This review can provide a theoretical basis to understand the interaction between NMs and the remineralization of dental hard tissue, thereby optimizing design strategy, rational development, and clinical application of NMs in the field of remineralization.

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A Comprehensive Review on Drug Therapies and Nanomaterials used in Orthodontic Treatment

Chauhan,

Kumar,

Chaurasia

et al. 2023

CPD

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Orthodontic treatment typically requires an extended duration of 1-2 years to complete the treatment. Accelerating the rate of tooth movement during orthodontic treatment is essential for shortening the overall treatment duration. After the completion of orthodontic treatment, a prominent concern arises in the form of orthodontic relapse, where the teeth tend to revert to their original positions. This issue affects approximately 60% of the global population, underscoring the importance of implementing effective measures to address orthodontic relapse. An approach in this regard involves the targeted administration of herbal and synthetic drugs applied directly to the specific area of interest to facilitate tooth movement and prevent orthodontic relapse. Apart from this, researchers are investigating the feasibility of utilizing different types of nanoparticles to improve the process of orthodontic tooth movement. In recent years, there has been a noticeable increase in the number of studies examining the effects of various drugs on orthodontics. However, the currently available literature does not provide significant evidence relating to orthodontic tooth movement. In this review, the authors provide valuable information about the drugs and nanomaterials that are capable of further enhancing the rate of orthodontic tooth movement and reducing the risk of orthodontic relapse. However, a notable hurdle remains, i.e., there is no marketed formulation available that can enhance orthodontic tooth movement and reduce treatment time. Therefore, researchers should try herbal-synthetic approaches to achieve a synergistic effect that can enhance orthodontic tooth movement. In this nutshell, there is an urgent need to develop a non-invasive, patient-compliant, and cost-effective formulation that will provide quality treatment and ultimately reduce the treatment time. Another critical issue is orthodontic relapse, which can be addressed by employing drugs that slow down osteoclastogenesis, thereby preventing tooth movement after treatment. Nevertheless, extensive research is still required to overcome this challenge in the future.

show abstract

Effect of locally delivered protein complex‐loaded nanoparticles on bone remodelling of atrophic alveolar ridge in beagles

Cited by 3 publications

References 28 publications

Prevention of bone dehiscence associated with orthodontic tooth movement by prophylactic injection of bone anabolic agents in mice

Prevention of bone dehiscence associated with orthodontic tooth movement by prophylactic injection of bone anabolic agents in mice

Unraveling Nanomaterials in Biomimetic Mineralization of Dental Hard Tissue: Focusing on Advantages, Mechanisms, and Prospects

A Comprehensive Review on Drug Therapies and Nanomaterials used in Orthodontic Treatment

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