Effect of locally delivered tetracycline hydrochloride as an adjunct to scaling and root planing on Hba1c, C-reactive protein, and lipid profile in type 2 diabetes: A clinico-biochemical study

Dodwad, Vidya; Ahuja, Sakshi; Kukreja, Bhavna Jha

doi:10.4103/0976-237x.96816

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…She found that those with diabetes showed improved metabolic control (i.e., lower A1C levels) 3 and 6 months after periodontal treatment. In another study, Dodwad et al ( 34 ) observed significant reductions in A1C and C-reactive protein in a group receiving tetracycline plus SRP compared to a group receiving SRP alone. A study by Telgi et al ( 35 ) concluded that nonsurgical periodontal therapy can effectively decrease A1C in people with type 2 diabetes who are on medication.…”

Section: Effects Of Periodontal Therapy On Glycemic Controlmentioning

confidence: 95%

Oral Manifestations of Diabetes

Indurkar

Maurya

Indurkar³

2016

Clinical Diabetes

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Section: Effects Of Periodontal Therapy On Glycemic Controlmentioning

confidence: 95%

Oral Manifestations of Diabetes

Indurkar

Maurya

Indurkar³

2016

Clinical Diabetes

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“…C-reactive protein, HbA1c, and lipid profile were the biochemical variables assessed at baseline and one and three months. There was a significant improvement in all clinical parameters, and the HbA1c levels in the tetracycline group asserted its beneficial effects over SRP only [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Probiotics Versus Tetracycline Fibers as Adjuvants to Scaling and Root Planing on Interleukin 1β Levels in Type 2 Diabetic Patients With Periodontitis: A Clinical and Biochemical Study

Gullapelli,

Koduganti

2023

Cureus

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Background Periodontitis, a chronic inflammatory disease, is triggered by the plaque biofilm culminating in periodontal attachment loss, bone loss, and tooth loss. Diabetes, a globally prevalent disease, causes an increased inflammatory response to the microflora associated with periodontitis. It has been observed that the link between these two diseases is bidirectional. Tissue repair is impaired in diabetic patients with periodontitis. Local drug delivery systems selectively target the inflamed sites contrary to systemic antibiotics which lead to resistance and many other adverse effects. Probiotics aid in the growth of beneficial microorganisms and have immunomodulatory effects on the host. Tetracyclines have anti-collagenase properties and reduce the bacterial load, curbing the progression of periodontitis. Interleukin (IL) 1β, a strong marker of periodontal tissue destruction, plays a pivotal role in inflammation, immune regulation, and bone resorption in periodontitis. This study evaluated and compared the benefits of probiotics and tetracycline fibers when used as adjunctive tools after scaling and root planing (SRP) on IL1β levels in type 2 diabetic patients with periodontitis. Methodology A total of 36 patients participated in this study. Group I included 12 patients with periodontitis and uncontrolled diabetes (HbA1c levels >7). After SRP, six patients received tetracycline fibers (IA), and six patients received probiotics (1B) as locally delivered agents. Group II included 12 patients with periodontitis and diabetes under control (HbA1c levels 6-7%). After SRP, six patients received tetracycline fibers (IIA), and six patients received probiotics (IIB) as locally delivered drugs (test groups). Group III, the control group, included 12 patients with periodontitis only, wherein a placebo was used as a local drug delivery (LDD) after SRP. The clinical parameters, such as plaque index, gingival index, and probing pocket depth, were recorded preoperatively and at eight and 12 weeks after non-surgical periodontal therapy. IL1β levels were assessed by enzyme-linked immunosorbent assay at baseline and six weeks after SRP. Results On intra and intergroup comparison, all groups showed improvement in both the clinical and biochemical parameters but significant results were seen in Group IIA (p < 0.01) when compared to the other groups. Conclusions Group II (well-controlled diabetics) performed significantly better than the other groups, which was followed by Group III. The use of LDDs as adjunctive tools after SRP was not beneficial in Group I (uncontrolled diabetics).

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“…The above findings were attributed to the proper maintenance of standardized oral hygiene instructions during the estimated time period of the study following the treatment at the baseline. 10 11 12 13 14 15 16 17 …”

Section: Discussionmentioning

confidence: 99%

IgA Levels among Type 2 Diabetic and Non-Diabetic Patients with Periodontitis: A Prospective Clinical Study

et al. 2022

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Objectives To estimate gingival crevicular immunoglobulin A(IgA) using enzyme-linked immunosorbent assay (ELISA) among type II diabetic patients with periodontitis. Materials and Methods A non-randomized study was done of 40 periodontitis subjects with a mean age of 50 years and were recruited into two groups, Group A (Type II controlled diabetics with HbA1c < 7%) and Group B (non-diabetics with HbA1c between 4 and 6%). Both the groups underwent nonsurgical periodontal therapy (NSPT). The clinical parameters were recorded at baseline, 1, and 3 months. GCF sample was collected for the estimation of crevicular IgA at baseline and at 3 months. Statistical Analysis Results were analyzed using parametric tests paired t-test and Student's t-test for every assessment point. The level of significance was set at p < 0.05. Results Difference in IgA levels and clinical parameters was seen between diabetic and non-diabetic groups, which was statistically significant. Conclusion Changes in crevicular IgA levels in patients with diabetic periodontitis can be used as a novel biomarker in assessing the inflammatory status.

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Effect of locally delivered tetracycline hydrochloride as an adjunct to scaling and root planing on Hba1c, C-reactive protein, and lipid profile in type 2 diabetes: A clinico-biochemical study

Cited by 6 publications

References 29 publications

Oral Manifestations of Diabetes

Oral Manifestations of Diabetes

Efficacy of Probiotics Versus Tetracycline Fibers as Adjuvants to Scaling and Root Planing on Interleukin 1β Levels in Type 2 Diabetic Patients With Periodontitis: A Clinical and Biochemical Study

IgA Levels among Type 2 Diabetic and Non-Diabetic Patients with Periodontitis: A Prospective Clinical Study

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