Effect of loganin on experimental diabetic nephropathy

Pterostilbene Alleviates Diabetic Nephropathy in Experimental Diabetic Rats; Inhibition of Aldose Reductase and Advanced Glycation End Products Formation

“…Results of the present study have corroborated with the previous reports in which administration of STZ led to the induction of diabetic nephropathy with a significant decrease in GFR which is evident from the elevated levels of serum creatinine and BUN [24]. However, administration of PST for 21 days resulted in improved kidney function by normaling kidney parameters like creatinine and BUN along with increased GFR in diabetic rats.…”

Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt/mTOR in experimental models of spinal muscular atrophy

“…Loganin has been mentioned for its glucose-lowering effect [27] and anti-diabetic nephropathic activity [31][32][33][34], but this study has first reported the potential muscle protective effect of loganin. In SMA, despite the above-mentioned beneficial effects of loganin such as SMN restoration and neuroprotection, the potential muscle protection of loganin via regulating two major protein synthesis pathways, a positive regulator Akt/mTOR pathway and a negative regulator atrogin-1/MuRF-1 pathway were also revealed in this study.…”

“…Loganin has been mentioned for its glucose-lowering effect [27] and anti-diabetic nephropathy activity [31][32][33][34]; however, the protective effects and mechanisms of loganin on SMN-deficient neuron and atrophic muscle are firstly investigated here. In the present study, the effects of loganin on SMA were investigated in a severe SMA animal model, SMA7 mice and in two cellular models of SMA, SMN-deficient motor neuron-like NSC34 cells and skin fibroblasts from SMA patients.…”

Application of Cornelian Cherry Iridoid-Polyphenolic Fraction and Loganic Acid to Reduce Intraocular Pressure

“…officinalis , grown in Asia has a strong beneficial effect on diabetic nephropathy [44]. Its activity was proven both in an animal model [45] and on the basis of traditional Chinese medicine [46]. According to Jiang, this activity is strongly connected with the methyl ester of loganic acid (loganin).…”