Effect of Long Term Administration of Atonik Compound in Female Rabbits on Hematological and Pathological Changes in Important Functional Body Organ

Abstract

Atonik is a synthetic bio stimulant consist of three phenolic compounds used as stimulant plant growth and development, farmers used atonik with high abuse for enhancements of fruit maturity so study done to detect the harmful effect of atonik in laboratory animal.Eight female rabbits of weighting (1.4-1.6) kg were obtained from animal house in college of Veterinary Medicine, animal housed two weeks before beginning study and all laboratory condition was taking into consideration. Animal randomly divided in to two main groups: Control group still without treatment at all period of study, Atonik group: each rabbits orally received 0.1 mg/kg /three time weekly (TIDW). Our result disturbance of hematological parameters specially WBCS, RBCS, HB and lymphocyte. Moreover histopathological section showing dilation of the central vein and filled with fluid and granuloma beside it, with vaculation of hypatocyte. Kidney reveals coagulative necrosis of renal tubules with distraction of glomerular tuft. Uterus of rabbits treated with 0.1 mg/kg bw atonik for 8 weeks showing necrosis of unrein glands. Ovary showed increase in the numbers of attratic follicles. Our result concluded that atonik has very harmful effect for reproduction, liver, and kidney.