Effect of Long-Term Anti-Hypertensive β-Receptor-Blocking Treatment on Haemodynamic and Metabolic Responses to Prolonged Exercise in Man

ABSTRACT. In 19 men aged 50 with essential hypertension, 18 weeks' treatment with atenolol (n=9) or oxprenolol (n=10) increased supine plasma free dopamine concentrations by 78% (p<0.05) and 121 % (p<0.001) respectively. Increments in plasma dopamine were observed in all patients except for one treated with atenolol. Supine peripheral venous adrenaline and noradrenaline concentrations were not influenced by β‐blockade. The mechanism and significance of the present elevation of plasma free dopamine by β‐blockade are unknown. However, increased plasma free dopamine may be involved in the hypotensive effect of chronic β‐adrenergic blockade, both β‐1 selective and non‐selective, and may lend further support to decreased dopaminergic activity in essential hypertenison.

show abstract

“…resistance seen after long-term treatment compared with acute or short-term administration of most /3-blockers (18, 19).…”

Section: Acta Med Scand 1983; 214mentioning

confidence: 99%

Increased Plasma Free Dopamine after Treatment with Atenolol and Oxprenolol in Essential Hypertension

Kjeldsen

Eide

Aakesson

et al. 1983

Journal of Internal Medicine

View full text Add to dashboard Cite

show abstract

Effects of labetalol and propranolol on blood pressure at rest and during isometric and dynamic exercise

Nyberg¹,

Vedin²,

Wilhelmsson³

1979

Eur J Clin Pharmacol

View full text Add to dashboard Cite

The influence of intravenous labetalol and propranolol on the blood pressure response to isometric and dynamic exercise was examined in a double blind study in eight, young, normotensive volunteers. Effects were recorded after propranolol 7.5, 15 and 30 mg i. v., and after labetalol 30, 60 and 120 mg i. v. In control experiments saline was administered. Mean blood pressure rose with successive handgrip tests following saline and propranolol, but not after labetalol, and the difference was significant. The total dose of each drug produced the same reduction in heart rate during sub-maximal bicycle exercise. The exercise-induced systolic blood pressure response did not differ between the drugs.

show abstract

Unterschiedlicher Einflu� einer chronischen, �berwiegend ?1-selektiven und ?1??2-Rezeptorenblockade auf den Kohlenhydratstoffwechsel

1980

Klin Wochenschr

View full text Add to dashboard Cite

1. The effects of long-term betal-selective (500 mg acebutolol) and nonselective (15 mg pindoloi) beta-receptor blockade on blood pressure, carbohydrate metabolism and plasma insulin and ACTH levels were studied at rest and during a short-telan (6 min, 100 W), long-term (30 min under steady state conditions with a heart rate of 130 min-1) and maximal ergometric work and 5 min after exercise in 11 moderately hypertensive men (mean 37 years) using a single-blind, crossover design.2. The ant±hypertensive effects of acebutolol and pindolol were virtually identical (p < 0.01) both at rest and in association with exercise. During exercise heart rates were similarly reduced by both drugs.3. However, there was a marked and significant drop in the blood glucose levels in the 30th min of ergometric work on .pindolol (P) as compared with acebutolol (A; p< 0.01) and with the Control group (C; p<0.001) (C69.1±8.9; A65.3+8.3; P54.5+ 8.7 mg/dl). The same phenomenon was observed during maximal work (C70.4-+10.7; A67.6-+8.7; P 54.1 ± 12 mg/dl). 4. Plasma insulin levels decreased significantly (p < 0.05) during exercise and were not significantly affected either by acebutolol or by pindolol.5. In the pretreatment examination there was a significant (p<0.05) increase of the plasma ACTH level in the 30th min of ergometric work. This concentration was not significantly affected by acebutolol but was increased by pindolol (p < 0.05) (C 60-+ 43.8 ; A 64 + 42.7 ; P 117.3 ± 108.8 pg/ml). * Mit Unterstfitzung des Bundesinstituts ffir SportwissenschaftSonderdruckanfragen an : Ass. Prof. Dr. med. I.-W. Franz (Adresse s. nach Literatur)

show abstract

Effect of Long-Term Anti-Hypertensive β-Receptor-Blocking Treatment on Haemodynamic and Metabolic Responses to Prolonged Exercise in Man

Cited by 3 publications

References 4 publications

Increased Plasma Free Dopamine after Treatment with Atenolol and Oxprenolol in Essential Hypertension

Increased Plasma Free Dopamine after Treatment with Atenolol and Oxprenolol in Essential Hypertension

Effects of labetalol and propranolol on blood pressure at rest and during isometric and dynamic exercise

Unterschiedlicher Einflu� einer chronischen, �berwiegend ?1-selektiven und ?1??2-Rezeptorenblockade auf den Kohlenhydratstoffwechsel

Contact Info

Product

Resources

About