Effect of long-term calcitonin therapy by injection and nasal spray on the incidence of fractures in osteogenesis imperfecta

Pamidronate Treatment of Less Severe Forms of Osteogenesis Imperfecta in Children

“…24 " 28 . Other agents, such as growth hormone, calcitonin, sodium fluoride and anabolic steroids, have not been shown to be associated with significant or sustained improvement in bone quality 15,29 . The primary objective of this study was to assess the effect of bisphosphonate treatment in children with milder forms of 01, in whom it is not routinely used.…”

Calcitonin in Osteoporosis

“…Accordingly, in 48 children with osteogenesis imperfecta treated with salmon calcitonin (2 IU/kg three times a week) for up to 48 weeks a reduction in annualized fracture rates relative to the pretreatment period was observed [110]. A decrease in fracture rate has also been reported in a Japanese series of patients with osteogenesis imperfecta treated sequentially with injectable and intermittent intranasal calcitonin regimens for 22-68 months [111]. The availability of other therapeutic options has reduced the interest for calcitonin in osteogenesis imperfecta, and no further studies have been conducted in the last decade.…”

Bone Mineral Density Deficits and Fractures in Survivors of Childhood Cancer

“…Currently, treatments for BMD deficits among childhood cancer survivors include dietary counseling and supplementation to ensure adequate calcium and vitamin D intake [85]. Vitamin D and calcium supplementation has demonstrated efficacy in children with decrements in BMD following diagnosis of juvenile rheumatoid arthritis [86], idiopathic juvenile osteoporosis [87] and osteogenesis imperfect [88]. Early identification and treatment of conditions that may exacerbate or accelerate bone loss, such as hypogonadism and GH deficiency, are also important in children or adolescents being treated for cancer [85].…”