Effect of long-term Centchroman treatment on plasma steroid and peptide hormones in female rhesus monkeys ()

Centchroman, a selective estrogen receptor modulator, as a contraceptive and for the management of hormone‐related clinical disorders

“…[97][98][99] No signi®cant effect has also been observed on follicular maturation, mating behaviour or ovulation in rats treated continuously with anti-implantation dose of centchroman either daily (0.25 mg/kg) 75 or at 120-hr intervals (1.25 mg/kg). 45 Centchroman (1.25 mg/kg, po) administered to lactating rats during entire lactation, too, produces no effect on time of onset of puberty and fertility performance at maturity of suckling young ones 20,21 or histology of ovaries and testes at 60, 90 and 120 days of age.…”

Development and validation of a rapid, sensitive liquid chromatography–tandem mass spectrometry method using electrospray ionization for quantitation of centchroman in rat plasma and its application to preclinical pharmacokinetic study

“…which justifies its unusually long half-life but inter-individual variability has been found to exist [6]. Its pharmacokinetic interactions with several co-administered drugs have been studied in Sprague-Dawley rats and drug has been found safe for long term uses [2,7,8].…”

“…Antiferitlity effect of this is due to its inherent estrogenic and antiestrogenic properties and found to decrease monoamine oxidase in pituitary and median eminence without decreasing levels in uterus [2][3][4]. It also has antiosteoporotic and anticancer activity [5].…”