Effect of long-term exposure to PM2.5 on the risk of type 2 diabetes and arthritis in type 2 diabetes patients: Evidence from a national cohort in China

Liu, Chaoqun; Cao, Ganxiang; Li, Jieying; Lian, Shaoyan; Zhao, Kang; Zhong, Ying; Xu, Jing; Chen, Yumeng; Bai, Jun; Feng, Hao; He, Guanhao; Dong, Xiaomei; Pan, Yang; Zeng, Fangfang; Lin, Ziqiang; Zhu, Shuang; Zhong, Xinqi; Ma, Wenjun; Liu, Tao

doi:10.1016/j.envint.2023.107741

Cited by 13 publications

(2 citation statements)

References 61 publications

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“…However, the results remain controversial. Many studies indicated the detrimental effect of PM 2.5 on overall arthritis (30,52). Indeed, future studies need to explore the relationship between specific arthritis and PM 2.5 exposure and identify the association between our score and specific arthritis.…”

Section: Discussionmentioning

confidence: 99%

Association between living environmental quality and risk of arthritis in middle-aged and older adults: a national study in China

Liu

Zhou

Liu

et al. 2023

Front. Public Health

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BackgroundThe association between combined environmental factors and the risk of arthritis is still scarcely studied. The present study performed cross-sectional and cohort studies to explore the association between risk score of living environment quality and the risk of arthritis in middle-aged and older adults in China.MethodsThe study was based on China Health and Retirement Longitudinal Study (CHARLS), and it recruited 17,218 participants in the cross-sectional study and 11,242 participants in the seven-year follow-up study. The living environment quality was measured by household fuel types, household water sources, room temperature, residence types, and ambient concentration of PM2.5. Logistic regression and Cox proportional hazard regression models were utilized to examine the association between the living environment quality and the risk of arthritis. Competing risk models and stratified analyses were applied to further verify our results.ResultsCompared with individuals in the suitable environment group, people who lived in moderate (OR:1.28, 95%CI: 1.14–1.43) and unfavorable environments (OR:1.49, 95%CI:1.31–1.70) showed higher risks of arthritis when considering the multiple living environmental factors (P for trend <0.001) in the cross-sectional analysis. In the follow-up study, similar results (P for trend = 0.021), moderate environment group (HR:1.26, 95%CI:1.01–1.56) and unfavorable environment group (HR: 1.36, 95%CI: 1.07–1.74), were founded.ConclusionInferior living environment might promote the development of arthritis. It is necessary for the public, especially old people, to improve the living environment, which may be the key to the primary prevention of arthritis.

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Section: Discussionmentioning

confidence: 99%

Association between living environmental quality and risk of arthritis in middle-aged and older adults: a national study in China

Liu

Zhou

Liu

et al. 2023

Front. Public Health

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“…Additionally, an interaction term was introduced into the models to examine potential interaction effects between blood selenium levels and covariates. Subsequently, subgroup analysis was conducted to evaluate interaction and the potential modifying effects of various important factors, including age, gender, education level, PIR, tobacco exposure, BMI, physical activity, alcohol consumption, hypertension, hyperuricemia, high total cholesterol (and heart failure) on the association of blood selenium levels with diabetes and heart failure [21,27].…”

Section: Discussionmentioning

confidence: 99%

Association of Blood Selenium Levels with Diabetes and Heart Failure in American General Adults: a Cross-sectional Study of NHANES 2011–2020 pre

Zhang,

Zeng,

Liu

et al. 2023

Biol Trace Elem Res

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Selenium is an essential trace element closely related to human health; however, the relationship between blood selenium levels, diabetes, and heart failure remains inconclusive. Therefore, this study aimed to explore the relationship between blood selenium levels and the prevalence of diabetes as well as heart failure in American general adults aged 20 years or older. This study utilized data from four survey cycles from NHANES 2011–2020 pre. Blood selenium levels were considered as both a continuous variable and quartiles, and logistic regression was employed to investigate the associations between blood selenium levels with diabetes and heart failure. Nonlinear relationships were examined by restricted cubic spline regression. The analysis included a total of 16311 participants aged 20 years or older. After adjustment for all potential confounder, we found when the blood selenium levels increased by 10 ug/L, the average risk of diabetes increased by 4.2% (95% CI: 1.5%, 7.0%), and the average risk of heart failure decreased by 5.0% (95% CI: 0.1%, 9.8%). In addition, compared with the lowest reference group, blood selenium levels were significantly positively associated with risk of diabetes in participants in the fourth quartile (OR=1.458, 95% CI: 1.173, 1.812), while significantly negatively associated with the risk of heart failure in participants in the second, third and fourth quartiles (Q2, OR=0.677, 95% CI: 0.471, 0.974) (Q3, OR=0.609, 95% CI: 0.426, 0.870) (Q4, OR=0.653, 95% CI: 0.443, 0.961). There was a nonlinear and reverse L-shaped association between blood selenium and diabetes, while a negative dose-response association between blood selenium and heart failure. Furthermore, the association between blood selenium levels and heart failure was more pronounced in participants with poor glycemic control, rather than diabetic patients. High blood selenium levels may be positively related to diabetes, while low blood selenium levels may be associated to heart failure. Appropriate blood selenium levels may help prevent diabetes and heart failure.

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Dynamic changes in ambient PM2.5 and body mass index among old adults: a nationwide cohort study

Yu,

Liu,

Liu

et al. 2023

Environ Sci Pollut Res

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Effect of long-term exposure to PM2.5 on the risk of type 2 diabetes and arthritis in type 2 diabetes patients: Evidence from a national cohort in China

Cited by 13 publications

References 61 publications

Association between living environmental quality and risk of arthritis in middle-aged and older adults: a national study in China

Association between living environmental quality and risk of arthritis in middle-aged and older adults: a national study in China

Association of Blood Selenium Levels with Diabetes and Heart Failure in American General Adults: a Cross-sectional Study of NHANES 2011–2020 pre

Dynamic changes in ambient PM2.5 and body mass index among old adults: a nationwide cohort study

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