Effect of long-term Helicobacter pylori infection on growth of children: a cohort study

Kocaoğlu, Çelebi; Özel, Ahmet; Cayci, Mustafa; Solak, Ece Selma

doi:10.1007/s12519-015-0021-7

Cited by 12 publications

(14 citation statements)

References 17 publications

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“…W e have read with great interest an article by Kocaoglu et al published in May issue of the World Journal of Pediatrics. [1] A total of 243 children aged between 8-18 years were examined based on growth determinants and existence of Helicobacter pylori (H. pylori) colonization in Turkey. The conclusion of this research is that H. pylori colonization affected children growth; and the longer duration of infection, the worse effect on growth.…”

Section: Lack Of Evidence For Helicobacter Pylori To Prevent Childrenmentioning

confidence: 99%

“…O ur study involved the children exposed to C14urea breath test to determine H. pylori infection after the admission because of dyspeptic complaints. [1] Those with a history of H. pylori infection were excluded, and 243 patients, 131 with H. pylori infection and 112 without H. pylori infection, were determined. Twelve patients in the H. pylori positive group and 18 in the H. pylori negative group were excluded because of the incompliance with the followup or therapy and re-infection.…”

Section: Lack Of Evidence For Helicobacter Pylori To Prevent Childrenmentioning

confidence: 99%

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Lack of evidence for Helicobacter pylori to prevent children growth efficiently

Abadi

Kocaoğlu

2016

World J Pediatr

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Section: Lack Of Evidence For Helicobacter Pylori To Prevent Childrenmentioning

confidence: 99%

Section: Lack Of Evidence For Helicobacter Pylori To Prevent Childrenmentioning

confidence: 99%

Lack of evidence for Helicobacter pylori to prevent children growth efficiently

Abadi

Kocaoğlu

2016

World J Pediatr

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“…Indeed, the bacterium is known to promote the development of chronic gastritis, peptic ulcer diseases, MALT lymphoma and gastric cancer in 10% of the infected population. Furthermore, there is growing evidence, mainly obtained from observational studies, showing that H. pylori infection may impair growth in children [3][4][5]. Indeed, H. pylori-inducedchronic gastritis results in the loss of appetite, malabsorption of nutrients, and dysregulation of the gastric endocrine and growth hormone systems, all of which may contribute to childhood growth impairment [6].…”

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confidence: 99%

Maternal H. pylori seropositivity is associated with gestational hypertension but irrelevant to fetal growth and development in early childhood

Lai

Sheu

et al. 2019

Preprint

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Background: Helicobacter pylori infection is known to alter growth-related hormones and cause growth faltering in young children. It is still unknown if maternal H. pylori infection has an impact on the levels of cord blood growth-related hormones and can predict intrauterine growth restriction and poor physical and neurodevelopmental outcomes in children. This study aimed to examine the associations between maternal H. pylori infection and pregnancy-related adverse events, fetal growth and early childhood development. Methods: The prospective cohort study recruited singleton pregnant women without major medical illnesses from January 2014 to January 2015. Seropositivity for H. pylori was defined by >12 U/ml of anti- H. pylori IgG in the maternal serum. Demographic data and pregnancy-related medical issues of the cohort were documented. Cord blood levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), insulin, and ghrelin were determined using ELISA test. The growth of eligible neonates was monitored annually for up to 3 years, and cognitive development was assessed using the comprehensive developmental inventory for infants and toddlers (CDIIT) test 3 years after birth. Results: Of the 106 enrolled women, 25 (23.6%) were H. pylori -seropositive. Maternal H. pylori seropositivity was correlated with a higher risk of developing gestational hypertension (GH) (12% vs. 1.2%, p =0.04) and lower cord blood levels of IGF-1 (<35 ng/ml, 70.0% vs. 40.7%, p =0.02) and IGFBP-3 (<1120 ng/ml, 100.0% vs. 76.3%, p =0.02) compared with the seronegative women. No significant impact on birth weight, childhood growth and cognitive development was found to correlate with maternal H. pylori seropositivity during pregnancy. Conclusions: Maternal H. pylori infection during pregnancy was more likely to develop GH, but not correlated with fetal and childhood growth and development. In addition to close monitoring of hypertension, H. pylori eradication can be considered for such H. pylori -infected mothers.

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“…Although it seldom causes clinical symptoms in children, chronic H. pylori infection can pose serious health threats, and the bacterium has been reported to promote the development of chronic gastritis, peptic ulcer diseases, MALT lymphoma and gastric cancer in 10% of the infected population. Furthermore, there is growing evidence, mainly obtained from observational studies, showing that H. pylori infection may impair growth in children [3][4][5]. H. pylori-induced chronic gastritis results in the loss of appetite, malabsorption of nutrients, and dysregulation of the gastric endocrine and growth hormone systems, all of which may contribute to childhood growth impairment [6].…”

mentioning

confidence: 99%

Maternal H. pylori seropositivity is associated with gestational hypertension but is irrelevant to fetal growth and development in early childhood

Lai

Sheu

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Helicobacter pylori infection is known to alter growth-related hormones and affect growth in young children. However, i t is still unknown whether maternal H. pylori infection has an impact on the levels of cord blood growth-related hormones and whether this can predict intrauterine growth restriction and poor physical and neurodevelopmental outcomes in children. This study aimed to examine associations between maternal H. pylori infection and pregnancy-related adverse events, fetal growth and early childhood development. Methods In this prospective cohort study, we recruited singleton pregnant women without major medical illnesses from January 2014 to January 2015. Seropositivity for H. pylori was defined as >12 U/ml of anti- H. pylori IgG in maternal serum. Demographic data and pregnancy-related medical issues of the cohort were documented. Cord blood levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), insulin, and ghrelin were determined using ELISA. The growth of the included neonates was monitored annually for up to 3 years, and cognitive development was assessed using the comprehensive developmental inventory for infants and toddlers (CDIIT) test 3 years after birth. Results Of the 106 enrolled women, 25 (23.6%) were H. pylori -seropositive. Maternal H. pylori seropositivity was correlated with a higher risk of developing gestational hypertension (GH) (12% vs. 1.2%, p =0.04) and lower cord blood levels of IGF-1 (<35 ng/ml, 70.0% vs. 40.7%, p =0.02) and IGFBP-3 (<1120 ng/ml, 100.0% vs. 76.3%, p =0.02) compared with the seronegative women. No significant impacts on birth weight, childhood growth and cognitive development were found to be correlated with maternal H. pylori seropositivity during pregnancy. Conclusions Maternal H. pylori infection during pregnancy was more likely to lead to the development of GH, but was not correlated with fetal and childhood growth and development. In addition to close monitoring of hypertension, H. pylori eradication can be considered for mothers with H. pylori infection .

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Effect of long-term Helicobacter pylori infection on growth of children: a cohort study

Abstract: As the duration of exposure is prolonged in children with H. pylori infection, the negative effect of the infection on both height and weight is evident.

Cited by 12 publications

References 17 publications

Lack of evidence for Helicobacter pylori to prevent children growth efficiently

Lack of evidence for Helicobacter pylori to prevent children growth efficiently

Maternal H. pylori seropositivity is associated with gestational hypertension but irrelevant to fetal growth and development in early childhood

Maternal H. pylori seropositivity is associated with gestational hypertension but is irrelevant to fetal growth and development in early childhood

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