Effect of long-term piceatannol treatment on eNOS levels in cultured endothelial cells

Kinoshita, Yosuke; Kawakami, S.; Yanae, Koji; Sano, Shoko; Uchida, Hiroko; Inagaki, Hideaki; Ito, Tatsuhiko

doi:10.1016/j.bbrc.2012.12.017

Cited by 35 publications

(36 citation statements)

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“…Although piceatannol shows activities similar to resveratrol, its levels in plants are significantly lower than those of resveratrol, 12) and it has therefore received far less research attention. We previously found that passion fruit seeds have a high piceatannol content, 13) and that piceatannol displays various properties such as sirtuin induction activity, 14) vasorelaxant effect, 15) upregulation of endothelial nitric oxide synthase expression, 16) promotion of collagen synthesis, inhibition of melanogenesis, 13) and protection of the skin from UVB irradiation. 17) Piceatannol shows much higher activity than resveratrol in some cases 13,16) ; however, its effects on metabolic syndrome remain unknown.…”

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confidence: 99%

“…We previously found that passion fruit seeds have a high piceatannol content, 13) and that piceatannol displays various properties such as sirtuin induction activity, 14) vasorelaxant effect, 15) upregulation of endothelial nitric oxide synthase expression, 16) promotion of collagen synthesis, inhibition of melanogenesis, 13) and protection of the skin from UVB irradiation. 17) Piceatannol shows much higher activity than resveratrol in some cases 13,16) ; however, its effects on metabolic syndrome remain unknown.Therefore, we explored the effect of piceatannol on high-fat diet (HFD)-induced obese mice. Furthermore, to explore the possibility of passion fruit seed extract (PFSE) as a functional food, PFSE and piceatannol were administered to genetically diabetic model mice (db/db mice).…”

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Piceatannol Lowers the Blood Glucose Level in Diabetic Mice

Uchida-Maruki

Inagaki

Ito

et al. 2015

Biological & Pharmaceutical Bulletin

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We previously found that passion fruit (Passiflora edulis) seeds contained a high amount of piceatannol (3,5,3′,4′-trans-tetrahydroxystilbene), a natural analog of resveratrol (3,5,4′-trans-trihydroxystilbene). Resveratrol has been proposed as a potential anti-metabolic disorder compound, by its activation of sirtuin and AMP-activated protein kinase. Many reports show that resveratrol ameliorates diet-induced obesity and insulin resistance. However, it is not known whether piceatannol also affects diet-induced obesity. We explored the effect of piceatannol on high fat diet-fed mice. The results showed that piceatannol did not affect high fat diet-induced body weight gain or visceral fat gain in mice. However, piceatannol did reduce fasting blood glucose levels. Furthermore, to explore the potential of passion fruit seed extract containing piceatannol as a functional food, passion fruit seed extract was administered in a genetic diabetic mouse model (db/db mice). Single administration of passion fruit seed extract, as well as piceatannol reduced the blood glucose levels of these db/db mice. These results suggest that piceatannol and passion fruit seed extract may have potential application in the prevention of diabetes.Key words piceatannol; passion fruit seed; antidiabetic activity; high fat diet; db/dbThe incidence of metabolic syndrome is increasing worldwide due to aging and changes in lifestyle. In particular, this increase is largely attributed to the rise in the prevalence of obesity, and this common metabolic disorder is associated with increased risk of cardiovascular diseases and type II diabetes, and the latter substantially decreases quality of life and increases health care costs. It is difficult to strictly control blood glucose levels over the long term, even though many anti-diabetic medications are clinically available. Therefore, the development of functional foods that can prevent or improve type II diabetes is an urgent matter.Resveratrol is a natural component of several plants, including grapes, berries, and peanuts. Resveratrol displays widespread functions and has several health-promoting effects owing to its anti-cancer, anti-inflammation, and antioxidant activity.1) Recently, resveratrol has been proposed as a potential anti-metabolic syndrome compound because of its role in activating sirtuin and AMP-activated protein kinase (AMPK).2-5) Indeed, several studies have shown that resveratrol protects mice against diet-induced obesity.6-8) Resveratrol has also been shown to have a favorable effect on glucose metabolism in humans.9,10) However, it should be noted that no weight loss has been reported after resveratrol treatment in any human study. 11)Piceatannol is a hydroxylated analog of resveratrol and is also found in various plants, including grapes and rhubarb. Although piceatannol shows activities similar to resveratrol, its levels in plants are significantly lower than those of resveratrol, 12) and it has therefore received far less research attention. We previously found that passion...

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confidence: 99%

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Piceatannol Lowers the Blood Glucose Level in Diabetic Mice

Uchida-Maruki

Inagaki

Ito

et al. 2015

Biological & Pharmaceutical Bulletin

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“…Determination of mRNA expression was performed as previously described [5]. Total RNA samples extracted from cells were reverse transcribed into complementary DNA, and real-time polymerase chain reactions (PCR) were performed in triplicate using a Light Cycler 480 Real-Time PCR system II (Roche Diagnostics, Mannheim, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…Our previous studies demonstrated that piceatannol is present in large amounts in passion fruit ( Passiflora edulis ) seeds [3]. We have also demonstrated that piceatannol displays a wide spectrum of biological activities, such as acute vasorelaxant effects in thoracic aorta [4], upregulation of endothelial nitric oxide synthase in endothelium [5], inhibition of melanogenesis, promotion of collagen synthesis [3], and protection of skin from UV-B irradiation [6]. …”

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confidence: 99%

Piceatannol and Its Metabolite, Isorhapontigenin, Induce SIRT1 Expression in THP-1 Human Monocytic Cell Line

et al. 2014

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Piceatannol is a phytochemical that is present in large amounts in passion fruit (Passiflora edulis) seeds, and is an analog of resveratrol. Recently, the absorption and metabolism of piceatannol were investigated in rats, and isorhapontigenin, O-methyl piceatannol, was detected as a piceatannol metabolite in rat plasma. To elucidate the function of piceatannol and its metabolites, we investigated the expression of sirtuin 1 (SIRT1) in THP-1 monocytic cells after treatment with piceatannol and its metabolites, and compared their effects with those of resveratrol and its metabolites. Piceatannol and resveratrol upregulated the expression levels of SIRT1 mRNA and SIRT1 protein. An extract of passion fruit seeds, which contained high levels of piceatannol, also upregulated SIRT1 mRNA expression. As for the metabolites, isorhapontigenin upregulated SIRT1 mRNA expression, whereas resveratrol glucuronides and sulfate did not affect SIRT1 expression. These findings indicate that after intake of piceatannol, not only piceatannol itself, but also its metabolite, isorhapontigenin, contributed to the upregulation of SIRT1 expression.

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“…Consequently, food safety is enhanced and the byproducts have a noble destination, also reducing the amount of wastes disposed of in the environment (Ferrari, Colussi, & Ayub, ; Haminiuk, Maciel, Plata‐Oviedo, & Peralta, ; Infante et al, ). The residual seeds from the juice industrialization and frozen pulp of yellow passion fruit ( Passiflora edulis ) are an important source of piceatannol, a natural stilbene that presents high antioxidant capacity (Matsui et al, ), anti‐inflammatory, vaso‐relaxing (Frombaum et al, ; Kinoshita et al, ; Sano, Sugiyama, Ito, Katano, & Ishihata, ; Seyed, Jantan, Bukhari, & Vijayaraghavan, ), antitumor, antidiabetic, and anti‐adipogenic properties (Kukreja, Mishra, & Tiwari, ; Piotrowska, Kucinska, & Murias, ; Uchida‐Maruki et al, ).…”

Section: Introductionmentioning

confidence: 99%

Hygroscopic equilibrium of microencapsulated extract of passion fruit seed and its effect on the antioxidant capacity

Silva

Oliveira

Demczuk

et al. 2017

J Food Process Engineering

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The hygroscopic behavior of microcapsules of antioxidant extract of defatted passion fruit seed, produced using spray drying technique, was analyzed at 20 and 40 °C by the static method with saturated saline solutions. The isosteric heat of sorption of the microcapsules, concentration of phenolic compounds and piceatannol, and the antioxidant capacity using ABTS and DPPH methods were measured during storage at different relative humidities. The isotherms were classified as GAB isotherms, exhibiting a Type II behavior. Isosteric heat of sorption decreased when the relative humidity increased and critical equilibrium moisture reached 61%. The microencapsulated extracts retained their antioxidant capacities within the evaluated conditions, what suggests that it may be applied in food at any of these water activity values. Practical applications Piceatannol is a stilbene with expressive antioxidant capacity which can be found in passion fruit seeds. In this work, the seeds were used to obtain the crude hydroethanolic extract which was microencapsulated by spray drying. The hygroscopic behavior of the microencapsulated extract of piceatannol was evaluated by fitting the data on different isotherm theoretical models. It was possible to verify the interference of the water activity in the antioxidant capacity and establish a relationship with possible critical storage conditions of the microencapsulated extract.

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Effect of long-term piceatannol treatment on eNOS levels in cultured endothelial cells

Cited by 35 publications

References 42 publications

Piceatannol Lowers the Blood Glucose Level in Diabetic Mice

Piceatannol Lowers the Blood Glucose Level in Diabetic Mice

Piceatannol and Its Metabolite, Isorhapontigenin, Induce SIRT1 Expression in THP-1 Human Monocytic Cell Line

Hygroscopic equilibrium of microencapsulated extract of passion fruit seed and its effect on the antioxidant capacity

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