Effect of lotus seedpod oligomeric procyanidins on AGEs formation in simulated gastrointestinal tract and cytotoxicity in Caco-2 cells

Wu, Qian; Zhao, Kuoquan; Chen, Yuanyuan; Ouyang, Yu; Feng, Yingna; Li, Shuyi; Liang, Zhang; Feng, Nianjie

doi:10.1039/d0fo03152f

Cited by 25 publications

(18 citation statements)

References 49 publications

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“…According to the preparation of various traditional medicines; for example, Chinese traditional medicines, Kampo medicines (the traditional Japanese herbal medicines), and Thai traditional medicines, these raw plant materials are commonly used in the form of an extract [ 12 , 13 , 14 , 15 ], following the traditional knowledge that the extract, which consists of major bioactive compounds, will provided synergistic effects for the health benefits of mankind. Nowadays, the number of research studies on the potential pharmacological activities of N. nucifera are considerably increased [ 7 , 8 , 9 , 10 , 11 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Flavonoids from Sacred Lotus Stamen Extract Slows Chronological Aging in Yeast Model by Reducing Oxidative Stress and Maintaining Cellular Metabolism

Drouet

Hano

2022

Cells

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Nelumbo nucifera is one of the most valuable medicinal species of the Nelumbonaceae family that has been consumed since the ancient historic period. Its stamen is an indispensable ingredient for many recipes of traditional medicines, and has been proved as a rich source of flavonoids that may provide an antiaging action for pharmaceutical or medicinal applications. However, there is no intense study on antiaging potential and molecular mechanisms. This present study was designed to fill in this important research gap by: (1) investigating the effects of sacred lotus stamen extract (LSE) on yeast lifespan extension; and (2) determining their effects on oxidative stress and metabolism to understand the potential antiaging action of its flavonoids. A validated ultrasound-assisted extraction method was also employed in this current work. The results confirmed that LSE is rich in flavonoids, and myricetin-3-O-glucose, quercetin-3-O-glucuronic acid, kaempferol-3-O-glucuronic acid, and isorhamnetin-3-O-glucose are the most abundant ones. In addition, LSE offers a high antioxidant capacity, as evidenced by different in vitro antioxidant assays. This present study also indicated that LSE delayed yeast (Saccharomyces cerevisiae, wild-type strain DBY746) chronological aging compared with untreated control yeast and a positive control (resveratrol) cells. Moreover, LSE acted on central metabolism, gene expressions (SIR2 and SOD2), and enzyme regulation (SIRT and SOD enzymatic activities). These findings are helpful to open the door for the pharmaceutical and medical sectors to employ this potential lotus raw material in their future pharmaceutical product development.

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Section: Introductionmentioning

confidence: 99%

Flavonoids from Sacred Lotus Stamen Extract Slows Chronological Aging in Yeast Model by Reducing Oxidative Stress and Maintaining Cellular Metabolism

Drouet

Hano

2022

Cells

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“…Phytochemicals from lotus seedpods have been determined to reveal a variety of biological activities, including ameliorating cognitive impairment ( 10 – 12 , 52 – 61 ), antioxidation ( 4 , 5 , 62 – 64 ), antibacterial ( 15 – 17 , 65 ), anti-glycative ( 7 , 18 , 19 ), neuroprotection ( 48 , 66 ), anti-tyrosinase ( 46 , 47 ), retinal protection ( 6 ), anti-insomnia ( 67 ), anti-cancer ( 68 ), immunomodulatory ( 69 ), ameliorating intestinal injury ( 70 ), anti-diabetes ( 20 ), regulating lipid homeostasis ( 38 ), anti-inflammatory ( 71 ) and α-glucosidase inhibitory ( 4 ) activities.…”

Section: Biological Activity Of Phytochemicals From Lotus Seedpodsmentioning

confidence: 99%

“…A variety of phytochemicals have been derived and identified from lotus seedpods, including proanthocyanidins ( 6 ), oligomeric procyanidins ( 7 ), polyphenols ( 8 ), flavonoids and others ( 9 ). Numerous studies have demonstrated that extracts and phytochemicals of lotus seedpods possessed various biological activities, such as ameliorating cognitive impairment ( 10 – 12 ), antioxidation ( 8 , 9 , 13 , 14 ), antibacterial ( 15 – 17 ), anti-glycative ( 7 , 18 , 19 ) and anti-diabetes ( 20 ). Due to the good biological activities and superior physicochemical property, raw material, extracts and phytochemicals of lotus seedpods have been increasingly applied in food and other industries ( 21 – 23 ).…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals, biological activity, and industrial application of lotus seedpod (Receptaculum Nelumbinis): A review

Wang

Shen

et al. 2022

Front. Nutr.

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Lotus (Nelumbo nucifera Gaertn.) is a well-known food and medicinal plant. Lotus seedpod (Receptaculum Nelumbinis) is the by-products during lotus products processing, which is considered as waste. Numerous studies have been conducted on its phytochemicals, biological activity and industrial application. However, the information on lotus seedpod is scattered and has been rarely summarized. In this review, summaries on preparation and identification of phytochemicals, the biological activities of extracts and phytochemicals, and applications of raw material, extracts and phytochemicals for lotus seedpod were made. Meanwhile, the future study trend was proposed. Recent evidence indicated that lotus seedpods extracts, obtained by non-organic and organic solvents, possessed several activities, which were influenced by extraction solvents and methods. Lotus seedpods were rich in phytochemicals categorized as different chemical groups, such as proanthocyanidins, oligomeric procyanidins, flavonoids, alkaloids, terpenoids, etc. These phytochemicals exhibited various bioactivities, including ameliorating cognitive impairment, antioxidation, antibacterial, anti-glycative, neuroprotection, anti-tyrosinase and other activities. Raw material, extracts and phytochemicals of lotus seedpods could be utilized as sources for biochar and biomass material, in food industry and as dye. This review gives well-understanding on lotus seedpod, and provides theoretical basis for its future research and application.

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“…As this lotus plant is widely used in both foods and herbal medicines, there are a large number of studies on its biological activities [ 8 , 9 , 10 , 11 , 12 , 13 ]. Most of the previous research studies focus on the leaves of N. nucifera ; for example, Lin and his team [ 3 ] isolated flavonoid phytochemical compounds from a leaf extract and reported on their antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Validation of a High-Performance Liquid Chromatography with Photodiode Array Detection Method for the Separation and Quantification of Antioxidant and Skin Anti-Aging Flavonoids from Nelumbo nucifera Gaertn. Stamen Extract

Drouet

Hano

2022

Molecules

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Nelumbo nucifera Gaertn., or the so-called sacred lotus, is a useful aquatic plant in the Nelumbonaceae family that has long been used to prepare teas, traditional medicines as well as foods. Many studies reported on the phytochemicals and biological activities of its leaves and seeds. However, to date, only few studies were conducted on its stamen, which is the most important ingredient for herbal medicines, teas and other phytopharmaceutical products. Thus, this present study focuses on the following: (1) the application of high-performance liquid chromatography with photodiode array detection for a validated separation and quantification of flavonoids from stamen; (2) the Nelumbo nucifera stamen’s in vitro and in cellulo antioxidant activities; as well as (3) its potential regarding the inhibition of skin aging enzymes for cosmetic applications. The optimal separation of the main flavonoids from the stamen ethanolic extract was effectively achieved using a core-shell column. The results indicated that stamen ethanolic extract has higher concentration of in vitro and in cellulo antioxidant flavonoids than other floral components. Stamen ethanolic extract showed the highest protective effect against reactive oxygen/nitrogen species formation, as confirmed by cellular antioxidant assay using a yeast model. The evaluation of potential skin anti-aging action showed that the stamen extract has higher potential to inhibit tyrosinase and collagenase compared with its whole flower. These current findings are the first report to suggest the possibility to employ N. nucifera stamen ethanolic extract as a tyrosinase and collagenase inhibitor in cosmetic applications, as well as the utility of the current separation method.

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Effect of lotus seedpod oligomeric procyanidins on AGEs formation in simulated gastrointestinal tract and cytotoxicity in Caco-2 cells

Abstract: This study explored the effects of lotus seedpod oligomeric procyanidins (LSOPC) and their main monomer catechin (CC) on the formation of advanced glycation end products (AGEs) and Caco-2 cytotoxicity during gastrointestinal digestion.

Cited by 25 publications

References 49 publications

Flavonoids from Sacred Lotus Stamen Extract Slows Chronological Aging in Yeast Model by Reducing Oxidative Stress and Maintaining Cellular Metabolism

Flavonoids from Sacred Lotus Stamen Extract Slows Chronological Aging in Yeast Model by Reducing Oxidative Stress and Maintaining Cellular Metabolism

Phytochemicals, biological activity, and industrial application of lotus seedpod (Receptaculum Nelumbinis): A review

Validation of a High-Performance Liquid Chromatography with Photodiode Array Detection Method for the Separation and Quantification of Antioxidant and Skin Anti-Aging Flavonoids from Nelumbo nucifera Gaertn. Stamen Extract

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