Effect of Low Birth Weight on Impaired Renal Development and Function and Hypertension in Rat Model

Xie, Zijian; Dong, Qin; Ge, Jianfang; Chen, Ping-Yang; Li, Wen; Hu, Jintao

doi:10.3109/0886022x.2012.676526

Cited by 11 publications

(29 citation statements)

References 28 publications

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“…Several epidemiological studies closely linked IUGR to adult onset diseases such as hypertension [1][2][3][4].Our previous rats study showed that low birth weight offspring of maternal protein restriction diet exposure decreased glomerular number and impaired renal function, and caused hypertension from postnatal 2 months old [5]. However, the basic mechanism that IUGR offspring led to later renal dysfunction was not fully uncovered.…”

Section: Effect Of Folic Acid Supplementation On Renal Phenotype and mentioning

confidence: 97%

“…the composition of diet was described in our previous study [5]. The animals were allowed free access to water and feed.…”

Section: Rats and Experimental Designmentioning

confidence: 99%

“…Pregnant rats were randomly divided into IUGR group (IUGR) and control group (Con). The IUGR model was modified from our previous paper [5]. In IUGR, the pregnant rats were fed 10% protein diet (protein restriction feed) only during pregnancy, and 21% protein diet (normal feed) during lactation.…”

Section: Rats and Experimental Designmentioning

confidence: 99%

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Effect of Folic Acid Supplementation on Renal Phenotype and Epigenotype in Early Weanling Intrauterine Growth Retarded Rats

Xie

Dong

et al. 2015

Kidney Blood Press Res

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Background/Aims: The objective of this study was to examine the responses of p53 promoter methylation involved in kidney structure and function of early weaning intrauterine growth retarded (IUGR) rats to dietary folic acid supplementation. Method: Sprague-Dawley rats were fed isocaloric diets containing either 21% protein diet (normal feed) or 10% protein diet throughout pregnancy and normal feed during lactation. After weaning, Offspring were then fed onto normal feed and normal feed supplemented with 5 mg folic acid/kg feed for a month, this produced 4 dietary groups (maternal diet/ weanling diet): Con, Folic, IUGR and IUGR+Folic. Renal function, renal structure, p53 promoter methylation and protein expression of offspring rats were measured at postnatal 2 months and 3 months. Results: Glomerular volume, blood urea nitrogen, 24 hours urine protein were significantly elevated in IUGR rats compared with Con rats but were decreased by dietary folic acid supplementation. p53 protein expression in IUGR rats were significantly higher than that in Con rats, and p53 promoter methylation status in IUGR rats was reduced significantly compared with Con rats. However, the changes in p53 gene expression and DNA methylation status of IUGR rats were reversed by dietary folic acid supplementation. Conclusions: Our study showed for the first time that folic acid supplementation during early period of life could reverse the abnormality in renal p53 methylation status and protein expression, glomerular volume and renal function of IUGR rats offspring.

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Section: Effect Of Folic Acid Supplementation On Renal Phenotype and mentioning

confidence: 97%

“…the composition of diet was described in our previous study [5]. The animals were allowed free access to water and feed.…”

Section: Rats and Experimental Designmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Folic Acid Supplementation on Renal Phenotype and Epigenotype in Early Weanling Intrauterine Growth Retarded Rats

Xie

Dong

et al. 2015

Kidney Blood Press Res

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“…The animals were housed in a room with temperature of 21-22˚C, humidity of 50-70% and a 12 h light/dark cycle. The composition of the diet was as previously described (14). There were 8-10 offspring in each nest during lactation, and nests with >14 offspring or <8 offspring were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…Pregnant rats were randomly divided into a control group (CON), an IUGR group (IUGR) and an L-Arg group (LA). The establishment of the IUGR model was conducted as described in our previous studies with modifications (14,15). The pregnant rats in the CON group were fed a 21% protein diet (normal feed) and normal water during pregnancy and lactation.…”

Section: Methodsmentioning

confidence: 99%

Effect of L-arginine supplementation on the hepatic phosphatidylinositol 3-kinase signaling pathway and gluconeogenic enzymes in early intrauterine growth-restricted rats

Luo

Chen

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to investigate the response of the phosphatidylinositol 3-kinase (PI3K) signaling pathway and gluconeogenic enzymes in intrauterine growth-restricted rats to dietary L-arginine (L-Arg) supplementation during the lactation period early in life. Pregnant Sprague-Dawley rats were randomly divided into a control group (CON), an intrauterine growth restriction group (IUGR) and an L-Arg group (LA). The pregnant rats in the CON group were fed a 21% protein diet, and those in the IUGR and LA groups were fed a 10% low protein diet, and all rats were fed a 21% protein diet after delivery. Water was available ad libitum to the pregnant rats during the 21-day lactation period, and the water provided to the LA group included 200 mg/kg/day L-Arg. Blood glucose, serum insulin, homeostasis model of assessment for insulin resistance (HOMA-IR), PI3K and protein kinase B (PKB) protein expression, and phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G-6-Pase) mRNA expression in the offspring rats were measured postnatally at 1, 3 and 8 weeks. No significant difference in blood glucose, serum insulin and HOMA-IR were identified at any time point among the three groups. PI3K and PKB expression was lower in the IUGR group offspring compared with that in the CON group offspring, but both were increased by dietary L-Arg supplementation. PEPCK mRNA and G-6-Pase mRNA expression levels in the offspring of the IUGR group were higher compared with those in the CON group but were downregulated following L-Arg supplementation. These results suggest that dietary L-Arg supplementation during the early lactation period promoted catch-up growth and reversed abnormalities in hepatic insulin signaling and gene expression of gluconeogenic enzymes in IUGR offspring rats.

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Glomerular filtration barrier in rat offspring exposed to maternal undernutrition

Alwasel

2017

Journal of King Saud University - Science

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Poor diet during pregnancy can increase blood pressure in offspring of human and laboratory animals. The present study examined the effects of moderate intrauterine undernutrition on the ultrastructure of the glomerular filtration barrier in 20-day-old rat fetuses and six-month-old rat offspring. Pregnant rats were provided with either ad libitum food during pregnancy (control group, C) or restricted to 50% of ad libitum food until delivery (food-restricted group, FR). Both groups were given free access to food after birth. The kidneys of embryonic day 20 and six-month-old rats were harvested. Transmission electron micrographs in glomeruli from both groups were obtained to study the ultrastructure of the glomerular filtration barrier. Blood pressure and glomerular filtration rate were measured in six-month-old rats. In comparison to the control group, the FR group had smaller body and kidney weights in both ages. Systemic blood pressure was significantly elevated in the FR group. The glomerular filtration rate was similar in both groups. A study of the glomerular ultrastructure showed a remarkable retardation in the development of the podocyte foot process in the FR group at embryonic day 20. Micrographs also showed remarkable changes in the glomerular filtration barrier of six-month-old rats including an increase in the thickness of the glomerular basement membrane and an increase in the width of filtration slits. These results suggest that maternal food restriction disturbs the development of the glomerular filtration barrier, which may contribute to hypertension in adult rat offspring. The long-term exposure to hypertension and glomerular hyperfiltration may have contributed to the damages observed in the glomerular filtration barrier of six-month-old rats exposed to intrauterine food restriction. Ó 2016 Production and Hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Effect of Low Birth Weight on Impaired Renal Development and Function and Hypertension in Rat Model

Abstract: These data showed that abnormal kidney development and renal dysfunction occurred in LBW rats due to a maternal low-protein diet. Possessing a decreased glomerular number might be a risk factor for hypertension in LBW rats.

Cited by 11 publications

References 28 publications

Effect of Folic Acid Supplementation on Renal Phenotype and Epigenotype in Early Weanling Intrauterine Growth Retarded Rats

Effect of Folic Acid Supplementation on Renal Phenotype and Epigenotype in Early Weanling Intrauterine Growth Retarded Rats

Effect of L-arginine supplementation on the hepatic phosphatidylinositol 3-kinase signaling pathway and gluconeogenic enzymes in early intrauterine growth-restricted rats

Glomerular filtration barrier in rat offspring exposed to maternal undernutrition

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